Academic Journal
Monkeypox Virus Dissemination in Case of Intranasal Infection of Mice
| Title: | Monkeypox Virus Dissemination in Case of Intranasal Infection of Mice |
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| Authors: | Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, O. V. P’Yankov, Ar. A. Sergeev, S. A. Bodnev, D. O. Gorbatovskaya, A. S. Zamedyanskaya, L. N. Shishkina, A. P. Agafonov, A. N. Sergeev |
| Source: | Проблемы особо опасных инфекций, Vol 0, Iss 4, Pp 86-90 (2015) |
| Publisher Information: | Russian Research Anti-Plague Institute Microbe, 2015. |
| Publication Year: | 2015 |
| Subject Terms: | динамика накопления, monkeypox virus, аутбредные мыши, dynamics of accumulation, intranasal infection, диссеминация, вирус оспы обезьян, Infectious and parasitic diseases, RC109-216, интраназальное инфицирование, dissemination, outbread mice, 3. Good health |
| Description: | By the experiments of in vivo intranasal infection of 8-10-days-old outbread ICR mice with Monkeypox virus (MPV) in a dose equal 3.83 lg FFU/specimen, investigated was dynamics of the virus accumulation within various organs, blood cells, and blood serum. In 2 days after infection MPV was detected in blood cells, nasal cavity, lungs, spleen, and duodenum, and in 5 days after - in brain, trachea, liver, kidneys, and blood serum. It was established that 7 days after infection the highest level of MPV production was in the lungs, nasal cavity, and brain, where virus titers in 5 % homogenates were (5.7±0.1), (5.5±0.1), and (5.3±0.3) lg FFU/ml, respectively. In the blood cells virus was traced in 2, 5, and 7 days after challenge, while in blood serum - in 5 and 7 days. MPV blood transfer to the secondary target organs (liver, spleen, duodenum, kidneys, et al. ) was operational, probably, due to the virus proliferation in blood corpuscles. The data obtained and the worked out scheme of MPV dissemination in an organism can be used for the selection and construction of therapeutic anti-pox virus preparations with precise targeted drug delivery. |
| Document Type: | Article Other literature type |
| ISSN: | 0370-1069 |
| DOI: | 10.21055/0370-1069-2015-4-86-90 |
| Access URL: | https://journal.microbe.ru/jour/article/download/272/269 https://doaj.org/article/31647faedd1e46d4a264605086d2cff7 https://journal.microbe.ru/jour/article/view/272/269 https://journal.microbe.ru/jour/article/download/272/269 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....8166e3faa24edcf78635aeba7cd6e0d7 |
| Database: | OpenAIRE |
| ISSN: | 03701069 |
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| DOI: | 10.21055/0370-1069-2015-4-86-90 |