Academic Journal
Mindfulness is associated with severity of peripheral neuropathy and related patient-reported outcomes among colorectal cancer patients
| Title: | Mindfulness is associated with severity of peripheral neuropathy and related patient-reported outcomes among colorectal cancer patients |
|---|---|
| Authors: | Bonhof, Cynthia S, van de Poll-Franse, Lonneke V, de Hingh, Ignace H, Vreugdenhil, Gerard, Mols, Floortje |
| Source: | Support Care Cancer |
| Publisher Information: | Springer Science and Business Media LLC, 2022. |
| Publication Year: | 2022 |
| Subject Terms: | Peripheral Nervous System Diseases/chemically induced, Research, Peripheral Nervous System Diseases, Colorectal Neoplasms/drug therapy, Netherlands/epidemiology, Antineoplastic Agents, Antineoplastic Agents/adverse effects, Fatigue/epidemiology, Severity of Illness Index, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Humans, Patient Reported Outcome Measures, Colorectal Neoplasms, Mindfulness, Fatigue, Neoplasm Staging, Netherlands |
| Description: | Purpose Despite the detrimental impact of chronic (chemotherapy-induced) peripheral neuropathy PN on patients’ lives, treatment options remain limited. We examined the association between mindfulness and chronic PN symptom severity and impairments in related patient-reported outcomes (PROs) among colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods Newly diagnosed stage I–IV CRC patients from four Dutch hospitals were eligible for participation. Patients (N = 336) completed a questionnaire on mindfulness (MAAS) at 1 year after diagnosis, and questionnaires on sensory (SPN) and motor peripheral neuropathy (MPN) (EORTC QLQ-CIPN20), anxiety and depressive symptoms (HADS), sleep quality (PSQI), and fatigue (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results At 1-year follow-up, 115 patients (34%) and 134 patients (40%), respectively, reported SPN or MPN symptoms. In multivariable regression analyses, higher mindfulness at 1-year follow-up was associated with less severe MPN and fewer anxiety and depressive symptoms, better sleep quality, and less fatigue. Of the patients with SPN or MPN at 1-year follow-up, symptoms had not returned to baseline level at 2-year follow-up in 59 (51%) and 72 (54%) patients, respectively. In this subgroup, higher mindfulness was associated with less severe SPN and fewer anxiety symptoms, depressive symptoms, and fatigue at 2-year follow-up. Conclusion Mindfulness was associated with less severe PN and better related PROs among CRC patients with chronic PN. More research is needed to examine the role of mindfulness in the transition from acute to chronic PN. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1433-7339 0941-4355 |
| DOI: | 10.1007/s00520-022-07340-8 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/36030458 https://research.tilburguniversity.edu/en/publications/af64e5a0-0f57-4d0c-85a3-9f8033ccc16e https://doi.org/10.1007/s00520-022-07340-8 https://cris.maastrichtuniversity.nl/en/publications/9dc807c0-bcda-4dcf-9ab8-1821fba0902d https://doi.org/10.1007/s00520-022-07340-8 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Accession Number: | edsair.doi.dedup.....7ea082e81266b7dedf4f86afc6e44bb0 |
| Database: | OpenAIRE |
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