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A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways

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Τίτλος: A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways
Συγγραφείς: Giovanni Maria Matrone, Eveline R. W. van Doremaele, Abhijith Surendran, Zachary Laswick, Sophie Griggs, Gang Ye, Iain McCulloch, Francesca Santoro, Jonathan Rivnay, Yoeri van de Burgt
Συνεισφορές: Chemistry, Chemical Science Program, KAUST Solar Center, KAUST Solar Center (KSC), Physical Sciences and Engineering, Physical Science and Engineering (PSE) Division, Microsystems, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612AJ, Eindhoven, The Netherlands, Department of Biomedical Engineering, Northwestern University, 60208, Evanston, IL, USA, Department of Chemistry, Chemistry Research Laboratory, University of Oxford, OX1 3TA, Oxford, UK, Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, 518060, Shenzhen, PR China, Tissue Electronics, Istituto Italiano di Tecnologia, 80125, Naples, Italy, Institute of Biological Information Processing IBI-3 Bioelectronics, Forschungszentrum Juelich, 52428, Juelich, Germany, Neuroelectronic Interfaces, Faculty of Electrical Engineering and IT, RWTH Aachen, 52074, Aachen, Germany
Πηγή: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Nature Communications 15, 2868 (2024). doi:10.1038/s41467-024-47226-3
Nature Communications
Στοιχεία εκδότη: Springer Science and Business Media LLC, 2024.
Έτος έκδοσης: 2024
Θεματικοί όροι: Neurons, 0301 basic medicine, Action Potentials/physiology, Neurotransmitter Agents, 0303 health sciences, Science, Action Potentials, Afferent, Article, 3. Good health, 03 medical and health sciences, Interneurons, Synapses, Humans, Neurons, Afferent, Neurons/physiology, Synapses/physiology
Περιγραφή: Signal communication mechanisms within the human body rely on the transmission and modulation of action potentials. Replicating the interdependent functions of receptors, neurons and synapses with organic artificial neurons and biohybrid synapses is an essential first step towards merging neuromorphic circuits and biological systems, crucial for computing at the biological interface. However, most organic neuromorphic systems are based on simple circuits which exhibit limited adaptability to both external and internal biological cues, and are restricted to emulate only specific the functions of an individual neuron/synapse. Here, we present a modular neuromorphic system which combines organic spiking neurons and biohybrid synapses to replicate a neural pathway. The spiking neuron mimics the sensory coding function of afferent neurons from light stimuli, while the neuromodulatory activity of interneurons is emulated by neurotransmitters-mediated biohybrid synapses. Combining these functions, we create a modular connection between multiple neurons to establish a pre-processing retinal pathway primitive.
Τύπος εγγράφου: Article
Other literature type
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
ISSN: 2041-1723
DOI: 10.1038/s41467-024-47226-3
DOI: 10.18154/rwth-2024-09059
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38570478
https://doaj.org/article/3ea8e15bc37c4ac2982fc87ec412c7b6
https://research.tue.nl/en/publications/3e454afd-159d-44b2-9af8-854ad8c368cb
https://doi.org/10.1038/s41467-024-47226-3
https://publications.rwth-aachen.de/record/994045
Rights: CC BY
Αριθμός Καταχώρησης: edsair.doi.dedup.....77efaf1b98f21b6f63d3599b4808b17c
Βάση Δεδομένων: OpenAIRE
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  Data: A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways
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  Data: <searchLink fieldCode="AR" term="%22Giovanni+Maria+Matrone%22">Giovanni Maria Matrone</searchLink><br /><searchLink fieldCode="AR" term="%22Eveline+R%2E+W%2E+van+Doremaele%22">Eveline R. W. van Doremaele</searchLink><br /><searchLink fieldCode="AR" term="%22Abhijith+Surendran%22">Abhijith Surendran</searchLink><br /><searchLink fieldCode="AR" term="%22Zachary+Laswick%22">Zachary Laswick</searchLink><br /><searchLink fieldCode="AR" term="%22Sophie+Griggs%22">Sophie Griggs</searchLink><br /><searchLink fieldCode="AR" term="%22Gang+Ye%22">Gang Ye</searchLink><br /><searchLink fieldCode="AR" term="%22Iain+McCulloch%22">Iain McCulloch</searchLink><br /><searchLink fieldCode="AR" term="%22Francesca+Santoro%22">Francesca Santoro</searchLink><br /><searchLink fieldCode="AR" term="%22Jonathan+Rivnay%22">Jonathan Rivnay</searchLink><br /><searchLink fieldCode="AR" term="%22Yoeri+van+de+Burgt%22">Yoeri van de Burgt</searchLink>
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  Data: Chemistry<br />Chemical Science Program<br />KAUST Solar Center<br />KAUST Solar Center (KSC)<br />Physical Sciences and Engineering<br />Physical Science and Engineering (PSE) Division<br />Microsystems, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612AJ, Eindhoven, The Netherlands<br />Department of Biomedical Engineering, Northwestern University, 60208, Evanston, IL, USA<br />Department of Chemistry, Chemistry Research Laboratory, University of Oxford, OX1 3TA, Oxford, UK<br />Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, 518060, Shenzhen, PR China<br />Tissue Electronics, Istituto Italiano di Tecnologia, 80125, Naples, Italy<br />Institute of Biological Information Processing IBI-3 Bioelectronics, Forschungszentrum Juelich, 52428, Juelich, Germany<br />Neuroelectronic Interfaces, Faculty of Electrical Engineering and IT, RWTH Aachen, 52074, Aachen, Germany
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  Data: Nat Commun<br />Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)<br />Nature Communications 15, 2868 (2024). doi:10.1038/s41467-024-47226-3<br />Nature Communications
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  Data: Signal communication mechanisms within the human body rely on the transmission and modulation of action potentials. Replicating the interdependent functions of receptors, neurons and synapses with organic artificial neurons and biohybrid synapses is an essential first step towards merging neuromorphic circuits and biological systems, crucial for computing at the biological interface. However, most organic neuromorphic systems are based on simple circuits which exhibit limited adaptability to both external and internal biological cues, and are restricted to emulate only specific the functions of an individual neuron/synapse. Here, we present a modular neuromorphic system which combines organic spiking neurons and biohybrid synapses to replicate a neural pathway. The spiking neuron mimics the sensory coding function of afferent neurons from light stimuli, while the neuromodulatory activity of interneurons is emulated by neurotransmitters-mediated biohybrid synapses. Combining these functions, we create a modular connection between multiple neurons to establish a pre-processing retinal pathway primitive.
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