Academic Journal
Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes
| Title: | Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes |
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| Authors: | Michaël Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Kitiporn Plaimas, Apichat Suratanee, Sunchai Payungporn |
| Source: | Acta Neuropsychiatrica. 35:328-345 |
| Publisher Information: | Cambridge University Press (CUP), 2023. |
| Publication Year: | 2023 |
| Subject Terms: | FOS: Computer and information sciences, Neuroimmune Interaction in Psychiatric Disorders, Phenome, Physiology, Bioinformatics, Economics, Macroeconomics, Major depressive disorder, Gene, Suicidal Ideation, Feces, Effects of Ketogenic Diet on Health, Adverse Childhood Experiences, Biochemistry, Genetics and Molecular Biology, Health Sciences, Mood, Genetics, Humans, Molecular Biology, Biology, Biological Psychiatry, Psychiatry, Depressive Disorder, Major, Obesity-associated Microbiome, Depression, Depression (economics), Life Sciences, Diversity and Function of Gut Microbiome, 3. Good health, Gastrointestinal Microbiome, Phenotype, FOS: Biological sciences, Medicine, Dysbiosis, Microbiome, Neuroscience |
| Description: | The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared in 2008 (Maeset al., 2008). The purpose of the present study is to delineate a) the microbiome signature of the phenome of depression, including suicidal behaviours (SB) and cognitive deficits; the effects of adverse childhood experiences (ACEs) and recurrence of illness index (ROI) on the microbiome; and the microbiome signature of lowered high-density lipoprotein cholesterol (HDLc). We determined isometric log-ratio abundances or prevalences of gut microbiome phyla, genera, and species by analysing stool samples from 37 healthy Thai controls and 32 MDD patients using 16S rDNA sequencing. Six microbiome taxa accounted for 36% of the variance in the depression phenome, namelyHungatellaandFusicatenibacter(positive associations) andButyricicoccus, Clostridium, Parabacteroides merdae, andDesulfovibrio piger(inverse association). This profile (labelled enterotype 1) indicates compositional dysbiosis, is strongly predicted by ACE and ROI, and is linked to SB. A second enterotype was developed that predicted a decrease in HDLc and an increase in the atherogenic index of plasma (Bifidobacterium, P. merdae, andRomboutsia were positively associated, whileProteobacteriaandClostridium sensu strictowere negatively associated). Together, enterotypes 1 and 2 explained 40.4% of the variance in the depression phenome, and enterotype 1 in conjunction with HDLc explained 39.9% of the variance in current SB. In conclusion, the microimmuneoxysome is a potential new drug target for the treatment of severe depression and SB and possibly for the prevention of future episodes. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1601-5215 0924-2708 |
| DOI: | 10.1017/neu.2023.21 |
| DOI: | 10.60692/3wyqr-wan09 |
| DOI: | 10.60692/z0kc7-5rr54 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/37052305 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....74d7588ccfbd8759a452ecf5cab1e183 |
| Database: | OpenAIRE |
| ISSN: | 16015215 09242708 |
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| DOI: | 10.1017/neu.2023.21 |