Academic Journal
Dentate gyrus is needed for memory retrieval
| Title: | Dentate gyrus is needed for memory retrieval |
|---|---|
| Authors: | Alejandro Carretero-Guillén, Mario Treviño, María Ángeles Gómez-Climent, Godwin K. Dogbevia, Ilaria Bertocchi, Rolf Sprengel, Matthew E. Larkum, Andreas Vlachos, Agnès Gruart, José M. Delgado-García, Mazahir T. Hasan |
| Source: | Mol Psychiatry Carretero-Guillén, Alejandro Treviño, M Gómez Climent, María Ángeles Dogbevia, GK Bertocchi, I Sprengel, R Larkum, ME Vlachos, A Gruart, A Delgado-García, JM Hasan, MT 2024 Dentate gyrus is needed for memory retrieval. Molecular Psychiatry 29 2939 2950 RODERIC. Repositorio Institucional de la Universitat de València instname Molecular Psychiatry |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Neurons, Male, 0301 basic medicine, 0303 health sciences, Hippocampus, Article, Optogenetics, 03 medical and health sciences, Memory, Dentate Gyrus, Mental Recall, Animals, Mental Recall/physiology [MeSH], Mental Recall/drug effects [MeSH], Optogenetics/methods [MeSH], Neurons/metabolism [MeSH], 42/41, 42, Animals [MeSH], Dentate Gyrus/physiology [MeSH], Memory/physiology [MeSH], Male [MeSH], Neurons/physiology [MeSH], 692/699, Clozapine/analogs, 96/44, 9/30, Hippocampus/physiology [MeSH], Rabbits [MeSH], Dentate Gyrus/drug effects [MeSH], Clozapine/pharmacology [MeSH], 631/378, Hippocampus/metabolism [MeSH], article, Rabbits, Clozapine |
| Description: | The hippocampus is crucial for acquiring and retrieving episodic and contextual memories. In previous studies, the inactivation of dentate gyrus (DG) neurons by chemogenetic- and optogenetic-mediated hyperpolarization led to opposing conclusions about DG’s role in memory retrieval. One study used Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-mediated clozapine N-oxide (CNO)-induced hyperpolarization and reported that the previously formed memory was erased, thus concluding that denate gyrus is needed for memory maintenance. The other study used optogenetic with halorhodopsin induced hyperpolarization and reported and dentate gyrus is needed for memory retrieval. We hypothesized that this apparent discrepancy could be due to the length of hyperpolarization in previous studies; minutes by optogenetics and several hours by DREADD/CNO. Since hyperpolarization interferes with anterograde and retrograde neuronal signaling, it is possible that the memory engram in the dentate gyrus and the entorhinal to hippocampus trisynaptic circuit was erased by long-term, but not with short-term hyperpolarization. We developed and applied an advanced chemogenetic technology to selectively silence synaptic output by blocking neurotransmitter release without hyperpolarizing DG neurons to explore this apparent discrepancy. We performed in vivo electrophysiology during trace eyeblink in a rabbit model of associative learning. Our work shows that the DG output is required for memory retrieval. Based on previous and recent findings, we propose that the actively functional anterograde and retrograde neuronal signaling is necessary to preserve synaptic memory engrams along the entorhinal cortex to the hippocampal trisynaptic circuit. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; pdf |
| Language: | English |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-024-02546-0 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38609585 https://hdl.handle.net/10550/106523 http://hdl.handle.net/21.11116/0000-000F-4677-D http://hdl.handle.net/21.11116/0000-000F-4679-B http://hdl.handle.net/21.11116/0000-000F-467A-A https://repository.publisso.de/resource/frl:6501140 https://hdl.handle.net/2318/1971250 https://doi.org/10.1038/s41380-024-02546-0 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....6819e3a2a55d0c99d7a6712265f7b796 |
| Database: | OpenAIRE |
| ISSN: | 14765578 13594184 |
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| DOI: | 10.1038/s41380-024-02546-0 |