Academic Journal
Investigation of gene–environment interactions in relation to tic severity
| Title: | Investigation of gene–environment interactions in relation to tic severity |
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| Authors: | Barbara J. Coffey, Julie Hagstrøm, Frank Visscher, Pieter J. Hoekstra, Andrea Dietrich, Thomas V. Fernandez, Mohamed Abdulkadir, Dongmei Yu, Lawrence W. Brown, Jay A. Tischfield, Eun-Young Shin, Keun-Ah Cheon, Athanasios Maras, Dong-Ho Song, Samuel H. Zinner, Astrid Morer, Jeremiah M. Scharf, Samuel Kuperman, Robert A. King, Isobel Heyman, Tammy Hedderly, Dorothy E. Grice, Kerstin J. Plessen, Yun-Joo Koh, Donald L. Gilbert, Hyun Ju Hong, Laura Ibanez-Gomez, Gary A. Heiman, Alexander Münchau, Young Shin Kim, Carol A. Mathews, Blanca Garcia-Delgar, Bennett L. Leventhal, Sodahm Kook, Young Key Kim, Marcos Madruga-Garrido, Veit Roessner, Chaim Huyser, Lisa Osiecki, Pablo Mir, Jungeun Song |
| Contributors: | National Institute of Mental Health (US), Tourette Syndrome Association of New Jersey, Judah Foundation, Tourette Association of America, National Institutes of Health (US), Instituto de Salud Carlos III, Junta de Andalucía, Sociedad Andaluza de Neurología, Fundación Alicia Koplowitz, Fundación Mutua Madrileña, Jacques and Gloria Gossweiler Foundation, Generalitat de Catalunya, German Research Foundation, National Institute of Environmental Health Sciences (US), Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Consejeria de Salud y Bienestar Social de la Junta de Andalucia, Consejeria de Economia, Innovacion, Ciencia y Empresa de la Junta de Andalucia, Instituto de Salud Carlos III. Spanish Government, Mohamed Abdulkadir, Dongmei Yu, Lisa Osiecki, Robert A King, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett Leventhal, Marcos Madruga-Garrido, Athanasios Maras, Pablo Mir, Astrid Morer, Alexander Münchau, Kerstin J Plessen, Veit Roessner, Eun-Young Shin, Dong-Ho Song, Jungeun Song, Frank Visscher, Samuel H Zinner, Carol A Mathews, Jeremiah M Scharf, Jay A Tischfield, Gary A Heiman, Andrea Dietrich, Pieter J Hoekstra, Cheon, Keun Ah |
| Source: | J Neural Transm (Vienna) Digital.CSIC. Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) instname RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía Journal of neural transmission, vol. 128, no. 11, pp. 1757-1765 Abdulkadir, M, Yu, D, Osiecki, L, King, R A, Fernandez, T V, Brown, L W, Cheon, K A, Coffey, B J, Garcia-Delgar, B, Gilbert, D L, Grice, D E, Hagstrøm, J, Hedderly, T, Heyman, I, Hong, H J, Huyser, C, Ibanez-Gomez, L, Kim, Y K, Kim, Y S, Koh, Y J, Kook, S, Kuperman, S, Leventhal, B, Madruga-Garrido, M, Maras, A, Mir, P, Morer, A, Münchau, A, Plessen, K J, Roessner, V, Shin, E Y, Song, D H, Song, J, Visscher, F, Zinner, S H, Mathews, C A, Scharf, J M, Tischfield, J A, Heiman, G A, Dietrich, A & Hoekstra, P J 2021, ' Investigation of gene–environment interactions in relation to tic severity ', Journal of Neural Transmission, vol. 128, no. 11, pp. 1757-1765 . https://doi.org/10.1007/s00702-021-02396-y Journal of neural transmission (Vienna, Austria : 1996), vol 128, iss 11 |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | 0301 basic medicine, Polimorfismo de nucleótido simple, Autism Spectrum Disorder, Autism, Neurodegenerative, Severity of Illness Index, Attention Deficit Disorder with Hyperactivity/genetics, Autism Spectrum Disorder/genetics, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Pregnancy, Tics, Tourette Syndrome, Gene–environment interaction, Pre- and perinatal complications, Tic severity, Tourette syndrome, 2.1 Biological and endogenous factors, Psychology, Predicción, Aetiology, Pediatric, 0303 health sciences, Serious Mental Illness, 3. Good health, Mental Health, Nucleótidos, Sitios genéticos, Mental health, Intellectual and Developmental Disabilities (IDD), Attention Deficit Disorder with Hyperactivity* / genetics, 03 medical and health sciences, Genetics, Metaanálisis, Neurotransmisores, Neurology & Neurosurgery, Autism Spectrum Disorder* / genetics, Human Genome, Psychiatry and Preclinical Psychiatric Studies - Original Article, Neurosciences, Trastorno obsesivo compulsivo, Gene-environment interaction, Brain Disorders, Genes, Attention Deficit Disorder with Hyperactivity, Trastorno del espectro autista, Síndrome de Tourette |
| Description: | Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive–compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene–environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene–environment studies. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: | English |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-021-02396-y |
| DOI: | 10.1101/2021.05.12.21257005 |
| DOI: | 10.13039/501100002809 |
| DOI: | 10.13039/501100001659 |
| DOI: | 10.13039/100008061 |
| DOI: | 10.13039/100008062 |
| DOI: | 10.13039/100000002 |
| DOI: | 10.13039/100008771 |
| DOI: | 10.13039/501100011011 |
| DOI: | 10.13039/100009575 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/100000066 |
| DOI: | 10.13039/501100008997 |
| Access URL: | https://link.springer.com/content/pdf/10.1007/s00702-021-02396-y.pdf https://europepmc.org/articles/pmc8536549?pdf=render https://pubmed.ncbi.nlm.nih.gov/34389898 http://hdl.handle.net/10261/269896 http://hdl.handle.net/10668/18374 https://research.rug.nl/en/publications/752a6a37-2bec-4452-9c76-869d5fbe516f https://hdl.handle.net/11370/752a6a37-2bec-4452-9c76-869d5fbe516f https://doi.org/10.1007/s00702-021-02396-y https://link.springer.com/article/10.1007%2Fs00702-021-02396-y https://pubmed.ncbi.nlm.nih.gov/34389898/ https://europepmc.org/article/PPR/PPR340433 https://link.springer.com/content/pdf/10.1007/s00702-021-02396-y.pdf https://paperity.org/p/269350392/investigation-of-gene-environment-interactions-in-relation-to-tic-severity https://www.ncbi.nlm.nih.gov/pubmed/34389898 https://www.medrxiv.org/content/10.1101/2021.05.12.21257005v1 https://medrxiv.org/content/10.1101/2021.05.12.21257005v1.full.pdf https://serval.unil.ch/notice/serval:BIB_6D97CD3D1149 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6D97CD3D11496 https://serval.unil.ch/resource/serval:BIB_6D97CD3D1149.P001/REF.pdf https://hdl.handle.net/10668/18374 https://curis.ku.dk/ws/files/301347390/Investigation.pdf https://discovery-pp.ucl.ac.uk/id/eprint/10132096/ https://escholarship.org/content/qt4177h5m7/qt4177h5m7.pdf https://escholarship.org/uc/item/4177h5m7 |
| Rights: | CC BY CC BY NC ND URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Accession Number: | edsair.doi.dedup.....4989ca9784d759cde2ac83fbc175b51a |
| Database: | OpenAIRE |
| ISSN: | 14351463 03009564 |
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| DOI: | 10.1007/s00702-021-02396-y |