Academic Journal
Evidence for two Ca2+-mobilizing purinoceptors on rat hepatocytes
| Title: | Evidence for two Ca2+-mobilizing purinoceptors on rat hepatocytes |
|---|---|
| Authors: | N M Woods, Peter H. Cobbold, K S R Cuthbertson, C J Dixon |
| Source: | Biochemical Journal. 269:499-502 |
| Publisher Information: | Portland Press Ltd., 1990. |
| Publication Year: | 1990 |
| Subject Terms: | Adenosine Diphosphate, Male, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Adenosine Triphosphate, Aequorin, Liver, Receptors, Purinergic, Animals, Calcium, Rats, Inbred Strains, Rats |
| Description: | Aequorin measurements of cytosolic free Ca2+ in single rat hepatocytes show that ADP and ATP, thought to act through the same P2Y purinoceptor, elicited very different responses in the majority of cells tested. ADP invariably induced transients of short duration (approx. 9 s), whereas ATP induced either similar transients or transients with a much longer duration (approx. 49 s). We explain this variability in terms of two separate purinoceptors on rat hepatocytes, one of which responds to either ATP or ADP to generate free-Ca2+ transients of short duration, and the other responds to ATP only, with transients of longer duration. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj2690499 |
| Access URL: | https://europepmc.org/articles/pmc1131604?pdf=render https://pubmed.ncbi.nlm.nih.gov/2386488 http://core.ac.uk/display/3666456 https://portlandpress.com/biochemj/article-pdf/269/2/499/600096/bj2690499.pdf https://core.ac.uk/display/3666456 https://europepmc.org/articles/PMC1131604 https://www.ncbi.nlm.nih.gov/pubmed/2386488 |
| Accession Number: | edsair.doi.dedup.....48dbb847aacf0cacc670a299a14c17c9 |
| Database: | OpenAIRE |
| ISSN: | 14708728 02646021 |
|---|---|
| DOI: | 10.1042/bj2690499 |