Academic Journal
Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis: Lessons about natural ictogenesis
| Title: | Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis: Lessons about natural ictogenesis |
|---|---|
| Authors: | Wolf, Peter |
| Source: | Wolf, P 2017, ' Reflex epileptic mechanisms in humans : Lessons about natural ictogenesis ', Epilepsy and Behavior, vol. 71, no. Pt B, pp. 118-123 . https://doi.org/10.1016/j.yebeh.2015.01.009 |
| Publisher Information: | Elsevier BV, 2017. |
| Publication Year: | 2017 |
| Subject Terms: | Myoclonus, Epilepsy, Epilepsy, Reflex/diagnosis, Provocation, Electroencephalography/methods, Electroencephalography, System epilepsies, Myoclonus/diagnosis, Epilepsy, Reflex, Focal epilepsies, 03 medical and health sciences, Juvenile myoclonic epilepsy, 0302 clinical medicine, Reflex/diagnosis, Seizures/diagnosis, Seizures, Reflex seizures, Reflex, Humans, Ictogenesis, Reflex/physiology, Seizure inhibition |
| Description: | The definition of reflex epileptic seizures is that specific seizure types can be triggered by certain sensory or cognitive stimuli. Simple triggers are sensory (most often visual, more rarely tactile or proprioceptive; simple audiogenic triggers in humans are practically nonexistent) and act within seconds, whereas complex triggers like praxis, reading and talking, and music are mostly cognitive and work within minutes. The constant relation between a qualitatively, often even quantitatively, well-defined stimulus and a specific epileptic response provides unique possibilities to investigate seizure generation in natural human epilepsies. For several reflex epileptic mechanisms (REMs), this has been done. Reflex epileptic mechanisms have been reported less often in focal lesional epilepsies than in idiopathic "generalized" epilepsies (IGEs) which are primarily genetically determined. The key syndrome of IGE is juvenile myoclonic epilepsy (JME), where more than half of the patients present reflex epileptic traits (photosensitivity, eye closure sensitivity, praxis induction, and language-induced orofacial reflex myocloni). Findings with multimodal investigations of cerebral function concur to indicate that ictogenic mechanisms in IGEs largely (ab)use preexisting functional anatomic networks (CNS subsystems) normally serving highly complex physiological functions (e.g., deliberate complex actions and linguistic communication) which supports the concept of system epilepsy. Whereas REMs in IGEs, thus, are primarily function-related, in focal epilepsies, they are primarily localization-related. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic". |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2015.01.009 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/25958226 https://pubmed.ncbi.nlm.nih.gov/25958226/ https://www.ncbi.nlm.nih.gov/pubmed/25958226 https://europepmc.org/article/MED/25958226 https://www.sciencedirect.com/science/article/pii/S1525505015000165 https://core.ac.uk/display/160502358 https://portal.findresearcher.sdu.dk/da/publications/4c28deb2-b7eb-4308-a035-1aa225db6939 https://portal.findresearcher.sdu.dk/da/publications/4c28deb2-b7eb-4308-a035-1aa225db6939 https://doi.org/10.1016/j.yebeh.2015.01.009 |
| Rights: | Elsevier TDM |
| Accession Number: | edsair.doi.dedup.....42f5b75ef23beb9ed3ba18f4973349aa |
| Database: | OpenAIRE |
Be the first to leave a comment!