Academic Journal
Increased risk of chronic kidney disease in children with anorectal malformations
| Τίτλος: | Increased risk of chronic kidney disease in children with anorectal malformations |
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| Συγγραφείς: | Esra Karabag Yilmaz, Ali Ekber Hakalmaz, Seha Saygılı, Ayse Agbas, Kubra Karatas, Memnune Nur Cebi, Rahsan Ozcan, Sebuh Kurugoglu, Mehmet Elicevik, Haluk Emir, Nur Canpolat |
| Συνεισφορές: | İstanbul University Cerrahpaşa Institutional Repository |
| Πηγή: | Journal of Pediatric Urology. 21:908-914 |
| Στοιχεία εκδότη: | Elsevier BV, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Male, Chronic Kidney Failure, Adolescent, Etiology, Epidemiology, Major Clinical Study, Medical Record Review, Urinary Tract Malformation, Risk Assessment, Article, Kidney Malformation, Urogenital Tract Malformation, Retrospective Study, Risk Factors, Chronic Kidney Disease, Diagnosis, Prevalence, Humans, Renal Insufficiency, Chronic, Child, Preschool Child, Children, Retrospective Studies, Vesicoureteral Reflux, Risk Factor, Bladder Dysfunction, Urinary Tract Infection, Anorectal Malformations, Creatinine Blood Level, Creatinine, Child, Preschool, Urogenital Abnormalities, Anorectal Malformation, Female, Complication, Kidney And Urinary Tract Anomalies, Human |
| Περιγραφή: | Anorectal malformations (ARM) are often accompanied by urological anomalies, which can contribute to the development of chronic kidney disease (CKD).This study aimed to investigate the prevalence of kidney and urinary tract anomalies, as well as bladder dysfunction, and their potential impact on the development of CKD in children with ARM.This single-center, retrospective study included 175 children with ARM, after excluding 75 children with missing data. Clinical and radiological findings and serum creatinine levels were obtained from medical records. Anorectal malformations were classified as "high" and "low" type based on the Wingspread classification, and also further classified by fistula type and sex distribution according to the Krickenbeck International Classification. CKD was defined and staged according to the KDIGO (Kidney Disease Improving Global Outcomes) guidelines.The median age of the patients was 9.7 years, with a male-to-female ratio of 1.13:1. Among the 175 patients, 97 (55 %) had intermediate or low-type ARM, and 78 (45 %) had high-type ARM. Kidney and/or urinary tract anomalies were identified in 85 patients (48.5 %), with 63 having kidney anomalies and 71 having urinary tract anomalies. The most common urinary tract anomaly was vesicoureteral reflux (n = 58). Bladder dysfunction was observed in 56 patients (32 %). CKD was diagnosed in 30 patients (17 %); six of them were in CKD stage 5, and the remaining 24 were in stages 2-4. The development of CKD was more common in both females and males with kidney anomalies (p |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1477-5131 |
| DOI: | 10.1016/j.jpurol.2025.03.015 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/40204571 https://hdl.handle.net/20.500.12831/25686 https://doi.org/10.1016/j.jpurol.2025.03.015 |
| Rights: | Elsevier TDM |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....3a82a08e0dd6bf0678b302b8b280eb9c |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14775131 |
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| DOI: | 10.1016/j.jpurol.2025.03.015 |