Academic Journal
Real-world characteristics and use patterns of patients treated with vericiguat: A nationwide longitudinal cohort study in Germany
| Τίτλος: | Real-world characteristics and use patterns of patients treated with vericiguat: A nationwide longitudinal cohort study in Germany |
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| Συγγραφείς: | Kerwagen, Fabian, Ohlmeier, Christoph, Evers, Thomas, Herrmann, Stefan, Bayh, Inga, Michel, Alexander, Kruppert, Silvia, Wilfer, Joanna, Wachter, Rolf, Böhm, Michael, Störk, Stefan |
| Πηγή: | Eur J Clin Pharmacol |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Male, Aged, 80 and over, Heart Failure, Assessment of Medication Adherence, ddc:610, Databases, Factual, Research, Age Factors, Middle Aged, Heterocyclic Compounds, 2-Ring, 03 medical and health sciences, Pyrimidines, Sex Factors, 0302 clinical medicine, Female [MeSH], Medication Adherence/statistics, Real-world, Age Factors [MeSH], Aged, 80 and over [MeSH], Heart failure, Aged [MeSH], Heart Failure/drug therapy [MeSH], Humans [MeSH], Longitudinal Studies [MeSH], Pyrimidines/administration, Retrospective Studies [MeSH], Middle Aged [MeSH], Databases, Factual [MeSH], Pyrimidines/therapeutic use [MeSH], Male [MeSH], Heterocyclic Compounds, 2-Ring [MeSH], Germany [MeSH], Pharmacoepidemiology, Vericiguat, Worsening heart failure, Practice Patterns, Physicians'/statistics, Sex Factors [MeSH], Germany, Humans, Female, Longitudinal Studies, Practice Patterns, Physicians', Aged, Retrospective Studies |
| Περιγραφή: | Purpose Vericiguat reduced clinical endpoints in patients experiencing worsening heart failure in clinical trials, but its implementation outside trials is unclear. Methods This retrospective analysis of longitudinally collected data was based on the IQVIA™ LRx database, which includes ~ 80% of the prescriptions of the 73 million people covered by the German statutory health insurance. Results Between September 2021 and December 2022, vericiguat was initiated in 2916 adult patients. Their mean age was 73 ± 13 years and 28% were women. While approximately 70% were uptitrated beyond 2.5 mg, only 36% reached 10 mg. Median time to up-titration from 2.5 mg to 5 mg was 17 (quartiles: 11–33) days, and from 2.5 to 10 mg 37 (25–64) days, respectively. In 87% of the patients, adherence to vericiguat was high as indicated by a medication possession ratio of ≥ 80%, and 67% of the patients persistently used vericiguat during the first year. Women and older patients reached the maximal dose of 10 mg vericiguat less often and received other substance classes of guideline-recommended therapy (GDMT) less frequently. The proportion of patients receiving four pillars of GDMT increased from 29% before vericiguat initiation to 44% afterwards. Conclusion In a real-world setting, despite higher age than in clinical trials, adherence and persistence of vericiguat appeared satisfactory across age categories. Initiation of vericiguat was associated with intensification of concomitant GDMT. Nevertheless, barriers to vericiguat up-titration and implementation of other GDMT, applying in particular to women and elderly patients, need to be investigated further. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-024-03654-0 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38472389 https://repository.publisso.de/resource/frl:6495609 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....1f2173fef8f201c2db76a6e6dd6b6b81 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14321041 00316970 |
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| DOI: | 10.1007/s00228-024-03654-0 |