Academic Journal
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy
| Title: | Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy |
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| Authors: | Nanna E. Andersen, Wolfgang Boehmerle, Petra Huehnchen, Tore B. Stage |
| Source: | Trends in Pharmacological Sciences. 45:872-879 |
| Publisher Information: | Elsevier BV, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Peripheral Nervous System Diseases/chemically induced, Peripheral Nervous System Diseases, in vitro, Antineoplastic Agents, Antineoplastic Agents/adverse effects, in vivo, neurofilament light chain, Neurofilament Proteins, neurotoxicity, Neurofilament Proteins/blood, Humans, Animals, clinical studies, Biomarkers/blood, Biomarkers, chemotherapy-induced peripheral neuropathy |
| Description: | Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy. The frequency of CIPN ranges from one in three to almost all patients depending on type of chemotherapy and dose. It causes symptoms that can range from sensitivity to touch and numbness to neuropathic pain in hands and feet. CIPN is notoriously difficult to grade objectively and has mostly relied on a clinician- or patient-based rating that is subjective and poorly reproducible. Thus, considerable effort has been aimed at identifying objective biomarkers of CIPN. Recent in vitro, animal, and clinical studies suggest that neurofilament light chain (NFL), a structural neuronal protein, may be an objective biomarker of CIPN. NFL released from cells to cell culture media reflects in vitro neurotoxicity, while NFL in serum reflects neuronal damage caused by chemotherapy in rodent models. Finally, NFL in serum may be a diagnostic biomarker of CIPN, but its prognostic ability to predict CIPN requires prospective evaluation. We discuss current limitations and future perspectives on the use of NFL as a preclinical and clinical biomarker of CIPN. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 0165-6147 |
| DOI: | 10.1016/j.tips.2024.08.001 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39242335 https://portal.findresearcher.sdu.dk/da/publications/6c176c52-ca26-44a4-a56d-b386178a2e12 https://doi.org/10.1016/j.tips.2024.08.001 |
| Rights: | Elsevier TDM |
| Accession Number: | edsair.doi.dedup.....074555155e964aeb14cc26a8673092d1 |
| Database: | OpenAIRE |
| ISSN: | 01656147 |
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| DOI: | 10.1016/j.tips.2024.08.001 |