Academic Journal
Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy
| Τίτλος: | Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy |
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| Συγγραφείς: | Rianne van Lieshout, Lidwine W. Tick, Erik A. M. Beckers, Willemijn Biesbroek, Jeanne P. Dieleman, Myrthe Dijkstra, Wanda Groenesteijn, Harry R. Koene, Suzanne Kranenburg, Debbie van der Lee, Liesbeth van der Put - van den Berg, Nicky Rademakers, Josien C. Regelink, Claudia J. van Tilborg, Peter E. Westerweel, Sandra de Zeeuw, Harry C. Schouten, Sandra Beijer |
| Πηγή: | European Journal of Clinical Nutrition. 78:1082-1094 |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Male, Adult, 0301 basic medicine, 2. Zero hunger, Nutritional Status, Middle Aged, 3. Good health, Leukemia, Myeloid, Acute, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Myelodysplastic Syndromes, Body Composition, Humans, Female, Prospective Studies, Nutrition Therapy, Fatigue, Aged |
| Περιγραφή: | Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often receive medical nutrition therapy (MNT) during intensive remission-induction treatment. Since little is known about changes in nutritional status, specifically body composition, in this patient population, these changes and their associations with physical and clinical outcomes were assessed.In this multicenter prospective observational study, newly diagnosed AML/MDS patients who received intensive remission-induction chemotherapy, routine dietary counseling by a dietician and MNT immediately upon inadequate nutritional intake, were included. At treatment initiation and discharge, nutritional status, including Patient-Generated Subjective Global Assessment (PG-SGA)-scores and body composition, physical outcomes and fatigue were assessed. Associations of nutritional status/body composition with physical outcomes, fatigue, fever duration, number of complications, time to neutrophil engraftment and hospital length of stay (LOS) (collected from medical records) were examined using multiple regression analysis.In >91% of the 126 AML/MDS patients included, nutritional intake was adequate, with 61% receiving MNT. Nevertheless, body weight decreased significantly (p |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/s41430-024-01488-8 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/39127840 https://cris.maastrichtuniversity.nl/en/publications/ea11e18e-2ec5-4ddf-8b6a-d99770584ae4 https://doi.org/10.1038/s41430-024-01488-8 |
| Rights: | Springer Nature TDM |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....0615d6ddd74b2b2e15ce4aa54eb7c2c5 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14765640 09543007 |
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| DOI: | 10.1038/s41430-024-01488-8 |