Academic Journal
Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy
| Title: | Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy |
|---|---|
| Authors: | Rianne van Lieshout, Lidwine W. Tick, Erik A. M. Beckers, Willemijn Biesbroek, Jeanne P. Dieleman, Myrthe Dijkstra, Wanda Groenesteijn, Harry R. Koene, Suzanne Kranenburg, Debbie van der Lee, Liesbeth van der Put - van den Berg, Nicky Rademakers, Josien C. Regelink, Claudia J. van Tilborg, Peter E. Westerweel, Sandra de Zeeuw, Harry C. Schouten, Sandra Beijer |
| Source: | European Journal of Clinical Nutrition. 78:1082-1094 |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Adult, 0301 basic medicine, 2. Zero hunger, Nutritional Status, Middle Aged, 3. Good health, Leukemia, Myeloid, Acute, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Myelodysplastic Syndromes, Body Composition, Humans, Female, Prospective Studies, Nutrition Therapy, Fatigue, Aged |
| Description: | Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often receive medical nutrition therapy (MNT) during intensive remission-induction treatment. Since little is known about changes in nutritional status, specifically body composition, in this patient population, these changes and their associations with physical and clinical outcomes were assessed.In this multicenter prospective observational study, newly diagnosed AML/MDS patients who received intensive remission-induction chemotherapy, routine dietary counseling by a dietician and MNT immediately upon inadequate nutritional intake, were included. At treatment initiation and discharge, nutritional status, including Patient-Generated Subjective Global Assessment (PG-SGA)-scores and body composition, physical outcomes and fatigue were assessed. Associations of nutritional status/body composition with physical outcomes, fatigue, fever duration, number of complications, time to neutrophil engraftment and hospital length of stay (LOS) (collected from medical records) were examined using multiple regression analysis.In >91% of the 126 AML/MDS patients included, nutritional intake was adequate, with 61% receiving MNT. Nevertheless, body weight decreased significantly (p |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/s41430-024-01488-8 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39127840 https://cris.maastrichtuniversity.nl/en/publications/ea11e18e-2ec5-4ddf-8b6a-d99770584ae4 https://doi.org/10.1038/s41430-024-01488-8 |
| Rights: | Springer Nature TDM |
| Accession Number: | edsair.doi.dedup.....0615d6ddd74b2b2e15ce4aa54eb7c2c5 |
| Database: | OpenAIRE |
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