Bibliographic Details
| Title: |
The effect of APOE4 on Alzheimer’s plasma biomarkers among Mexican Americans in the HABS-HD cohort |
| Authors: |
J. A. Contreras, N. E. Ortega, K. Espejo, V. Aslanyan, J. Pa, Sid E. O’Bryan, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Mónica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre-Guerra, Carl Hill, Rocky Vig |
| Source: |
Alzheimer's Research & Therapy. 17 |
| Publisher Information: |
Springer Science and Business Media LLC, 2025. |
| Publication Year: |
2025 |
| Description: |
Background and objectives The relationship between APOE4 status and plasma biomarkers previously shown to be related to Alzheimer’s risk have not been carefully examined among Mexican Americans. This research is needed to elucidate disparities within the Alzheimer’s field by evaluating key genetic factors in an underrepresented population. The present study deepens our understanding of the interaction between biological and genetic factors for these populations with greater incidence of Alzheimer’s disease (AD) and helps address whether APOE4 confers similar risk of AD in Mexican Americans as previously reported in Non-Hispanic Whites. Methods Cross-sectional data consisting of 792 Mexican American and 785 Non-Hispanic White participants from the Health & Aging Brain Study – Health Disparities (HABS-HD) with available plasma biomarkers and APOE4 genotype profiles were included in the present study. Linear regression models were used to test our hypotheses. APOE4—Race/ethnicity interaction term tested whether the biomarker levels differed between ethnic groups. Analyses were adjusted for age, gender, and education. Further analyses explored whether biomarker levels differed by APOE4 carrier status within racial/ethnic groups. Results Among 1577 participants (59.5% women; mean age 66.4 ± 8.74 years), significant differences were observed across race/ethnic and APOE4 groups. Mexican Americans were younger (p p = 0.001), fewer years of education (p p p = 0.03) and p-tau181 (p p > 0.12). Race/ethnicity—APOE4 interactions were significant for Aβ42/Αβ40, p-tau181, and total tau (all p APOE4 associations with Aβ42/Aβ40 and p-tau181 were significant in NH White participants (all p Conclusion These findings will significantly contribute to understanding potential differences in the role of APOE4 and AD plasma biomarkers among Mexican Americans. This research has the potential to enhance preventive care and early diagnosis for populations with a higher incidence of AD. |
| Document Type: |
Article |
| Language: |
English |
| ISSN: |
1758-9193 |
| DOI: |
10.1186/s13195-025-01845-0 |
| Rights: |
CC BY |
| Accession Number: |
edsair.doi...........c2c940f7a7ccc24a8a16e53ef49d9256 |
| Database: |
OpenAIRE |