Bibliographic Details
| Title: |
Scaled-up Processes for the Preparation of Enhanced Antibacterial ZnO-Menthol, ZnO-Chitosan, and ZnO-Triclosan Flake/Spine-like Nanocomposites, and their Biocompatibility and Toxicity Studies |
| Authors: |
Rajapakshe Babilage Sanjitha Dilan Rajapakshe, Charith Anuruddha Thennakoon, Nishananthy Nagarasa, Sayuri Sammanani Niyangoda, Siddartha Kalpa Samadhi Thennakoon, Rajapakse Mudiyanselage Gamini Rajapakse, R. G. Sanath C. Rajapakse |
| Source: |
Current Nanoscience. 21:1067-1096 |
| Publisher Information: |
Bentham Science Publishers Ltd., 2025. |
| Publication Year: |
2025 |
| Subject Terms: |
0103 physical sciences, 01 natural sciences, 0104 chemical sciences |
| Description: |
Introduction: Nanomaterials, especially their biocompatibilities and toxicities, have not been studied and their integration in real applications is still limited. Methods: This paper addresses this gap by focusing on the development of antibacterial nanomaterials by combining flake/spinal ZnO nanostructures with organic antibacterial agents (menthol, chitosan, and triclosan). We systematically study their biocompatibility and toxicity, intending to apply them practically on fabric surfaces. Results: Based on the known photocatalytic and antibacterial properties of ZnO, our hypothesis suggests that the unique flake/spine ZnO nanostructures can further improve the antibacterial efficacy through induced mechanistic approaches. The synergistic effect achieved by combining ZnO with menthol, chitosan, and triclosan improves the overall bactericidal ability. XRD, XRF, FTIR, SEM, and UV-visible spectroscopy are used to characterize the nanocomposites. The antibacterial properties of the modified fabrics are tested using standard spread plate techniques. Biocompatibility and toxicity studies using a mouse model provide a comprehensive picture of the safety profile. Conclusion: This work advances the understanding of antibacterial nanomaterials, and paves the way for their wider manufacturing and practical use in textiles, meeting the industrial needs of antimicrobial clothing and wound dressings. |
| Document Type: |
Article |
| Language: |
English |
| ISSN: |
1573-4137 |
| DOI: |
10.2174/0115734137325025241031151832 |
| Accession Number: |
edsair.doi...........b90939929181e58a5080806b580b82d0 |
| Database: |
OpenAIRE |