Academic Journal
Numerical Simulation of Bone Defect Repair Using a Triply Periodic Minimal Surface Scaffold.
| Τίτλος: | Numerical Simulation of Bone Defect Repair Using a Triply Periodic Minimal Surface Scaffold. |
|---|---|
| Συγγραφείς: | Chen, Zhouyang, Chen, Haifei, Qu, Chuanyong |
| Πηγή: | Journal of Functional Biomaterials; May2026, Vol. 17 Issue 5, p257, 19p |
| Θεματικοί όροι: | Tissue scaffolds, Finite element method, Bone growth, Computer simulation, Strains & stresses (Mechanics), Bone regeneration, Minimal surfaces, Material biodegradation |
| Περίληψη: | Polylactic acid (PLA) scaffolds with triply periodic minimal surface (TPMS) structures have become ideal scaffolds in the field of bone defect repair due to their good designability, connectivity, biocompatibility, and degradability. However, it is currently difficult to obtain the scaffold degradation rate and osteogenic efficacy from in vivo experiments, making it challenging to provide recommendations for scaffold design. In this study, an algorithm to construct a TPMS scaffold–interfacial layer–tissue three-phase composite model was developed using polylactic acid hydrolysis and bone remodeling as the governing equations to simulate scaffold degradation and tissue osteogenesis behavior under an external mechanical stimulus. This method is based on a numerical calculation framework that can more closely simulate the in vivo environment, characterizing the changes in the overall macroscopic mechanical properties of tissue under the influence of scaffold degradation and tissue osteogenesis. The results confirmed the accelerating effect of mechanical stimulation on scaffold degradation and its promoting effect on new bone formation. Under 10% compressive loading, the Schwarz P representative volume element (RVE) lost 33% of its apparent modulus within initial days, while the lidinoid RVE, despite showing a much higher initial modulus, dropped to only 20% of its initial value over the same period. In addition, the mechanical performance of the fused TPMS RVE was not simply linear, even though the surface equations are combined linearly. These results provide a new method for pre-designing scaffold structures based on numerical simulation results using the finite element simulation. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Functional Biomaterials is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Biomedical Index |
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| Header | DbId: edm DbLabel: Biomedical Index An: 194118458 RelevancyScore: 1061 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1060.76245117188 |
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| Items | – Name: Title Label: Title Group: Ti Data: Numerical Simulation of Bone Defect Repair Using a Triply Periodic Minimal Surface Scaffold. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen%2C+Zhouyang%22">Chen, Zhouyang</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Haifei%22">Chen, Haifei</searchLink><br /><searchLink fieldCode="AR" term="%22Qu%2C+Chuanyong%22">Qu, Chuanyong</searchLink> – Name: TitleSource Label: Source Group: Src Data: Journal of Functional Biomaterials; May2026, Vol. 17 Issue 5, p257, 19p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Tissue+scaffolds%22">Tissue scaffolds</searchLink><br /><searchLink fieldCode="DE" term="%22Finite+element+method%22">Finite element method</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+growth%22">Bone growth</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+simulation%22">Computer simulation</searchLink><br /><searchLink fieldCode="DE" term="%22Strains+%26+stresses+%28Mechanics%29%22">Strains & stresses (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+regeneration%22">Bone regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Minimal+surfaces%22">Minimal surfaces</searchLink><br /><searchLink fieldCode="DE" term="%22Material+biodegradation%22">Material biodegradation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Polylactic acid (PLA) scaffolds with triply periodic minimal surface (TPMS) structures have become ideal scaffolds in the field of bone defect repair due to their good designability, connectivity, biocompatibility, and degradability. However, it is currently difficult to obtain the scaffold degradation rate and osteogenic efficacy from in vivo experiments, making it challenging to provide recommendations for scaffold design. In this study, an algorithm to construct a TPMS scaffold–interfacial layer–tissue three-phase composite model was developed using polylactic acid hydrolysis and bone remodeling as the governing equations to simulate scaffold degradation and tissue osteogenesis behavior under an external mechanical stimulus. This method is based on a numerical calculation framework that can more closely simulate the in vivo environment, characterizing the changes in the overall macroscopic mechanical properties of tissue under the influence of scaffold degradation and tissue osteogenesis. The results confirmed the accelerating effect of mechanical stimulation on scaffold degradation and its promoting effect on new bone formation. Under 10% compressive loading, the Schwarz P representative volume element (RVE) lost 33% of its apparent modulus within initial days, while the lidinoid RVE, despite showing a much higher initial modulus, dropped to only 20% of its initial value over the same period. In addition, the mechanical performance of the fused TPMS RVE was not simply linear, even though the surface equations are combined linearly. These results provide a new method for pre-designing scaffold structures based on numerical simulation results using the finite element simulation. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Journal of Functional Biomaterials is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/jfb17050257 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 257 Subjects: – SubjectFull: Tissue scaffolds Type: general – SubjectFull: Finite element method Type: general – SubjectFull: Bone growth Type: general – SubjectFull: Computer simulation Type: general – SubjectFull: Strains & stresses (Mechanics) Type: general – SubjectFull: Bone regeneration Type: general – SubjectFull: Minimal surfaces Type: general – SubjectFull: Material biodegradation Type: general Titles: – TitleFull: Numerical Simulation of Bone Defect Repair Using a Triply Periodic Minimal Surface Scaffold. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen, Zhouyang – PersonEntity: Name: NameFull: Chen, Haifei – PersonEntity: Name: NameFull: Qu, Chuanyong IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20794983 Numbering: – Type: volume Value: 17 – Type: issue Value: 5 Titles: – TitleFull: Journal of Functional Biomaterials Type: main |
| ResultId | 1 |