Academic Journal
Helicobacter pylori and risk of upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors.
| Τίτλος: | Helicobacter pylori and risk of upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors. |
|---|---|
| Συγγραφείς: | Dall, Michael, Schaffalitzky de Muckadell, Ove B., Møller Hansen, Jane, Wildner-Christensen, Mette, Touborg Lassen, Annmarie, Hallas, Jesper |
| Πηγή: | Scandinavian Journal of Gastroenterology; Sep2011, Vol. 46 Issue 9, p1039-1044, 6p, 2 Charts |
| Θεματικοί όροι: | Serotonin uptake inhibitors, Gastrointestinal hemorrhage, Helicobacter pylori infections, Nonsteroidal anti-inflammatory agents, Case studies, Aspirin, Disease risk factors |
| Γεωγραφικοί όροι: | Fyn (Denmark), Denmark |
| Περίληψη: | Background. A number of studies have reported a possible association between use of selective serotonin reuptake inhibitors (SSRIs) and serious upper gastrointestinal bleeding (UGB). We conducted this case--control study to assess if Helicobacter pylori ( H. pylori) potentiates the risk of serious UGB in SSRI users. Material and methods. A population-based case--control study was conducted in the county of Funen, Denmark. Cases were 53 SSRI users with serious UGB whose H. pylori status on their bleeding date could be established. Controls ( n == 723) were selected among subjects who participated in a population H. pylori screening study, and who were users of SSRIs. Data on drug exposure and medical history were retrieved from a prescription database and the county's patient register. Confounders were controlled for by unconditional logistic regression. Results. H. pylori infection increased the risk of serious UGB in patients using SSRI with an adjusted odds ratio (OR) of 2.73 (95% confidence interval (CI), 1.17--6.36). The adjusted OR for serious UGB among users of non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) were 3.91 (95% CI, 2.03--7.52) and 3.00 (95% CI, 0.94--9.54), respectively. Conclusion. H. pylori infection increases the risk of SSRI-related serious UGB. [ABSTRACT FROM AUTHOR] |
| Copyright of Scandinavian Journal of Gastroenterology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
| FullText | Text: Availability: 0 |
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| Header | DbId: edb DbLabel: Complementary Index An: 64002589 RelevancyScore: 834 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 834.06103515625 |
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| Items | – Name: Title Label: Title Group: Ti Data: Helicobacter pylori and risk of upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dall%2C+Michael%22">Dall, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Schaffalitzky+de+Muckadell%2C+Ove+B%2E%22">Schaffalitzky de Muckadell, Ove B.</searchLink><br /><searchLink fieldCode="AR" term="%22Møller+Hansen%2C+Jane%22">Møller Hansen, Jane</searchLink><br /><searchLink fieldCode="AR" term="%22Wildner-Christensen%2C+Mette%22">Wildner-Christensen, Mette</searchLink><br /><searchLink fieldCode="AR" term="%22Touborg+Lassen%2C+Annmarie%22">Touborg Lassen, Annmarie</searchLink><br /><searchLink fieldCode="AR" term="%22Hallas%2C+Jesper%22">Hallas, Jesper</searchLink> – Name: TitleSource Label: Source Group: Src Data: Scandinavian Journal of Gastroenterology; Sep2011, Vol. 46 Issue 9, p1039-1044, 6p, 2 Charts – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+hemorrhage%22">Gastrointestinal hemorrhage</searchLink><br /><searchLink fieldCode="DE" term="%22Helicobacter+pylori+infections%22">Helicobacter pylori infections</searchLink><br /><searchLink fieldCode="DE" term="%22Nonsteroidal+anti-inflammatory+agents%22">Nonsteroidal anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Case+studies%22">Case studies</searchLink><br /><searchLink fieldCode="DE" term="%22Aspirin%22">Aspirin</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Fyn+%28Denmark%29%22">Fyn (Denmark)</searchLink><br /><searchLink fieldCode="DE" term="%22Denmark%22">Denmark</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background. A number of studies have reported a possible association between use of selective serotonin reuptake inhibitors (SSRIs) and serious upper gastrointestinal bleeding (UGB). We conducted this case--control study to assess if Helicobacter pylori ( H. pylori) potentiates the risk of serious UGB in SSRI users. Material and methods. A population-based case--control study was conducted in the county of Funen, Denmark. Cases were 53 SSRI users with serious UGB whose H. pylori status on their bleeding date could be established. Controls ( n == 723) were selected among subjects who participated in a population H. pylori screening study, and who were users of SSRIs. Data on drug exposure and medical history were retrieved from a prescription database and the county's patient register. Confounders were controlled for by unconditional logistic regression. Results. H. pylori infection increased the risk of serious UGB in patients using SSRI with an adjusted odds ratio (OR) of 2.73 (95% confidence interval (CI), 1.17--6.36). The adjusted OR for serious UGB among users of non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) were 3.91 (95% CI, 2.03--7.52) and 3.00 (95% CI, 0.94--9.54), respectively. Conclusion. H. pylori infection increases the risk of SSRI-related serious UGB. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Scandinavian Journal of Gastroenterology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3109/00365521.2011.580100 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1039 Subjects: – SubjectFull: Fyn (Denmark) Type: general – SubjectFull: Denmark Type: general – SubjectFull: Serotonin uptake inhibitors Type: general – SubjectFull: Gastrointestinal hemorrhage Type: general – SubjectFull: Helicobacter pylori infections Type: general – SubjectFull: Nonsteroidal anti-inflammatory agents Type: general – SubjectFull: Case studies Type: general – SubjectFull: Aspirin Type: general – SubjectFull: Disease risk factors Type: general Titles: – TitleFull: Helicobacter pylori and risk of upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dall, Michael – PersonEntity: Name: NameFull: Schaffalitzky de Muckadell, Ove B. – PersonEntity: Name: NameFull: Møller Hansen, Jane – PersonEntity: Name: NameFull: Wildner-Christensen, Mette – PersonEntity: Name: NameFull: Touborg Lassen, Annmarie – PersonEntity: Name: NameFull: Hallas, Jesper IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00365521 Numbering: – Type: volume Value: 46 – Type: issue Value: 9 Titles: – TitleFull: Scandinavian Journal of Gastroenterology Type: main |
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