Academic Journal
The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial.
| Τίτλος: | The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. |
|---|---|
| Συγγραφείς: | Bongers, Marloes E. J., De Lorijn, Fleur, Reitsma, Johannes B., Groeneweg, Michael, Taminiau, Jan A. J. M., Benninga, Marc A. |
| Πηγή: | Nutrition Journal; 2007, Vol. 6, p8-7, 7p, 1 Diagram, 3 Charts |
| Θεματικοί όροι: | Infant formulas, Constipation, Infants, Palmitic acid, Oligosaccharides, Feces |
| Περίληψη: | Background: Nutrilon Omneo (new formula; NF) contains high concentration of sn-2 palmitic acid, a mixture of prebiotic oligosaccharides and partially hydrolyzed whey protein. It is hypothesized that NF positively affects stool characteristics in constipated infants. Methods: Thirty-eight constipated infants, aged 3-20 weeks, were included and randomized to NF (n = 20) or a standard formula (SF; n = 18) in period 1 and crossed-over after 3 weeks to treatment period 2. Constipation was defined by at least one of the following symptoms: 1) defecation frequency < 3/week; 2) painful defecation; 3) abdominal or rectal palpable mass. Results: Period 1 was completed by 35 infants. A significant increase in defecation frequency (NF: 3.5 pre versus 5.6/week post treatment; SF 3.6 pre versus 4.9/week post treatment) was found in both groups, but was not significantly different between the two formulas (p = 0.36). Improvement of hard stool consistency to soft stool consistency was found more often with NF than SF, but did not reach statistical significance (90% versus 50%; RR, 1.8; 95% CI, 0.9-3.5; p = 0.14). No difference was found in painful defecation or the presence of an abdominal or rectal mass between the two groups. Twenty-four infants completed period 2. Only stool consistency was significantly different between the two formulas (17% had soft stools on NF and hard stools on SF; no infants had soft stools on SF and hard stools on NF, McNemar test p = 0.046). Conclusion: The addition of a high concentration sn-2 palmitic acid, prebiotic oligosaccharides and partially hydrolyzed whey protein resulted in a strong tendency of softer stools in constipated infants, but not in a difference in defecation frequency. Formula transition to NF may be considered as treatment in constipated infants with hard stools. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bongers%2C+Marloes+E%2E+J%2E%22">Bongers, Marloes E. J.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Lorijn%2C+Fleur%22">De Lorijn, Fleur</searchLink><br /><searchLink fieldCode="AR" term="%22Reitsma%2C+Johannes+B%2E%22">Reitsma, Johannes B.</searchLink><br /><searchLink fieldCode="AR" term="%22Groeneweg%2C+Michael%22">Groeneweg, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Taminiau%2C+Jan+A%2E+J%2E+M%2E%22">Taminiau, Jan A. J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Benninga%2C+Marc+A%2E%22">Benninga, Marc A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Nutrition Journal; 2007, Vol. 6, p8-7, 7p, 1 Diagram, 3 Charts – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Infant+formulas%22">Infant formulas</searchLink><br /><searchLink fieldCode="DE" term="%22Constipation%22">Constipation</searchLink><br /><searchLink fieldCode="DE" term="%22Infants%22">Infants</searchLink><br /><searchLink fieldCode="DE" term="%22Palmitic+acid%22">Palmitic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Oligosaccharides%22">Oligosaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Feces%22">Feces</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Nutrilon Omneo (new formula; NF) contains high concentration of sn-2 palmitic acid, a mixture of prebiotic oligosaccharides and partially hydrolyzed whey protein. It is hypothesized that NF positively affects stool characteristics in constipated infants. Methods: Thirty-eight constipated infants, aged 3-20 weeks, were included and randomized to NF (n = 20) or a standard formula (SF; n = 18) in period 1 and crossed-over after 3 weeks to treatment period 2. Constipation was defined by at least one of the following symptoms: 1) defecation frequency < 3/week; 2) painful defecation; 3) abdominal or rectal palpable mass. Results: Period 1 was completed by 35 infants. A significant increase in defecation frequency (NF: 3.5 pre versus 5.6/week post treatment; SF 3.6 pre versus 4.9/week post treatment) was found in both groups, but was not significantly different between the two formulas (p = 0.36). Improvement of hard stool consistency to soft stool consistency was found more often with NF than SF, but did not reach statistical significance (90% versus 50%; RR, 1.8; 95% CI, 0.9-3.5; p = 0.14). No difference was found in painful defecation or the presence of an abdominal or rectal mass between the two groups. Twenty-four infants completed period 2. Only stool consistency was significantly different between the two formulas (17% had soft stools on NF and hard stools on SF; no infants had soft stools on SF and hard stools on NF, McNemar test p = 0.046). Conclusion: The addition of a high concentration sn-2 palmitic acid, prebiotic oligosaccharides and partially hydrolyzed whey protein resulted in a strong tendency of softer stools in constipated infants, but not in a difference in defecation frequency. Formula transition to NF may be considered as treatment in constipated infants with hard stools. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Nutrition Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/1475-2891-6-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 8 Subjects: – SubjectFull: Infant formulas Type: general – SubjectFull: Constipation Type: general – SubjectFull: Infants Type: general – SubjectFull: Palmitic acid Type: general – SubjectFull: Oligosaccharides Type: general – SubjectFull: Feces Type: general Titles: – TitleFull: The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bongers, Marloes E. J. – PersonEntity: Name: NameFull: De Lorijn, Fleur – PersonEntity: Name: NameFull: Reitsma, Johannes B. – PersonEntity: Name: NameFull: Groeneweg, Michael – PersonEntity: Name: NameFull: Taminiau, Jan A. J. M. – PersonEntity: Name: NameFull: Benninga, Marc A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 14752891 Numbering: – Type: volume Value: 6 Titles: – TitleFull: Nutrition Journal Type: main |
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