Academic Journal
Functional Significance of Passive and Active Dendritic Properties in the Synaptic Integration by an Identified Nonspiking Interneuron of Crayfish.
| Τίτλος: | Functional Significance of Passive and Active Dendritic Properties in the Synaptic Integration by an Identified Nonspiking Interneuron of Crayfish. |
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| Συγγραφείς: | Akira Takashima |
| Πηγή: | Journal of Neurophysiology; Dec2006, Vol. 96 Issue 6, p3157-3169, 13p |
| Θεματικοί όροι: | Interneurons, Synapses, Computer simulation, Crayfish |
| Περίληψη: | Nonspiking interneurons control their synaptic output directly by membrane potential changes caused by synaptic activities. Although these interneurons do not generate spikes, their dendritic membrane is endowed with a variety of voltage-dependent conductances whose functional significance in synaptic integration remains unknown. We quantitatively investigated how the passive and active dendritic properties affect the synaptic integration in an identified nonspiking interneuron of crayfish by computer simulation using its multicompartment model based on electrophysiological measurements and three-dimensional morphometry. At the resting potential level, the attenuation factor (Vs/Vt) of a unitary synaptic potential in the course of its spread from a dendritic terminal (Vs) to other terminals (Vt) ranged from 4.42 to 6.30 with no substantial difference between hyperpolarizing and depolarizing potentials. The compound synaptic responses to strong mechanosensory stimulation could be reproduced in calculation only as the result of spatial summation of attenuated potentials, not as any single large potential. The characteristic response could be reproduced by assuming that the active conductances were distributed only in the dendritic region where the synaptic summation was carried out. The active conductances in other parts of the cell affected neither the shape of the compound synaptic response nor the dendritic spread of synaptic potentials. These findings suggest that the active membrane conductances do not affect the spatial distribution of synaptic potentials over dendrites but function in sculpting the summed synaptic potential to enhance temporal resolution in the synaptic output of the nonspiking interneuron. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Neurophysiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Functional Significance of Passive and Active Dendritic Properties in the Synaptic Integration by an Identified Nonspiking Interneuron of Crayfish. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Akira++Takashima%22">Akira Takashima</searchLink> – Name: TitleSource Label: Source Group: Src Data: Journal of Neurophysiology; Dec2006, Vol. 96 Issue 6, p3157-3169, 13p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Interneurons%22">Interneurons</searchLink><br /><searchLink fieldCode="DE" term="%22Synapses%22">Synapses</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+simulation%22">Computer simulation</searchLink><br /><searchLink fieldCode="DE" term="%22Crayfish%22">Crayfish</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Nonspiking interneurons control their synaptic output directly by membrane potential changes caused by synaptic activities. Although these interneurons do not generate spikes, their dendritic membrane is endowed with a variety of voltage-dependent conductances whose functional significance in synaptic integration remains unknown. We quantitatively investigated how the passive and active dendritic properties affect the synaptic integration in an identified nonspiking interneuron of crayfish by computer simulation using its multicompartment model based on electrophysiological measurements and three-dimensional morphometry. At the resting potential level, the attenuation factor (Vs/Vt) of a unitary synaptic potential in the course of its spread from a dendritic terminal (Vs) to other terminals (Vt) ranged from 4.42 to 6.30 with no substantial difference between hyperpolarizing and depolarizing potentials. The compound synaptic responses to strong mechanosensory stimulation could be reproduced in calculation only as the result of spatial summation of attenuated potentials, not as any single large potential. The characteristic response could be reproduced by assuming that the active conductances were distributed only in the dendritic region where the synaptic summation was carried out. The active conductances in other parts of the cell affected neither the shape of the compound synaptic response nor the dendritic spread of synaptic potentials. These findings suggest that the active membrane conductances do not affect the spatial distribution of synaptic potentials over dendrites but function in sculpting the summed synaptic potential to enhance temporal resolution in the synaptic output of the nonspiking interneuron. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Journal of Neurophysiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1152/jn.00680.2006 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 3157 Subjects: – SubjectFull: Interneurons Type: general – SubjectFull: Synapses Type: general – SubjectFull: Computer simulation Type: general – SubjectFull: Crayfish Type: general Titles: – TitleFull: Functional Significance of Passive and Active Dendritic Properties in the Synaptic Integration by an Identified Nonspiking Interneuron of Crayfish. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Akira Takashima IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00223077 Numbering: – Type: volume Value: 96 – Type: issue Value: 6 Titles: – TitleFull: Journal of Neurophysiology Type: main |
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