Academic Journal
Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs.
| Τίτλος: | Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs. |
|---|---|
| Συγγραφείς: | Wang, Yuman, Chang, Teding, Fu, Yangguang, Liang, Guangyu, Liu, Huicheng, Zhang, Le, Yan, Jinhua, Liu, Man, Liu, Anding, Zhang, Cuntai |
| Πηγή: | Aging Cell; Oct2026, Vol. 25 Issue 10, p1-26, 26p |
| Θεματικοί όροι: | Aging, Interleukin-6, Fibroblast growth factors, RNA sequencing, Myeloid cells, Inflammation |
| Περίληψη: | Aging is accompanied by progressive immune remodeling and functional decline across multiple organs. However, the role of neutrophils and their heterogeneous states in these processes remains incompletely understood. Here we integrated single‐cell RNA sequencing datasets from multiple organs of young and aged mice to characterize aging‐associated neutrophil remodeling. We identified organ‐dependent changes in neutrophil abundance and state composition, together with neutrophil subsets enriched for inflammatory, oxidative stress, complement, and IL‐6‐related transcriptional programs. In vitro, exposure to conditioned media from neutrophils isolated from aged mice or IL‐6‐stimulated neutrophil‐like cells increased inflammatory and senescence‐associated responses in vascular smooth muscle and hepatocyte‐derived cells. Bone marrow single‐cell analysis further revealed aging‐associated shifts in progenitor composition and transcriptional states, including an old‐enriched HPC11 population characterized by enhanced myeloid priming. Silico perturbation analysis nominated FGF didate regulators of HPC subtype‐specific transcriptional programs. Together, our study provides a multi‐organ single‐cell resource for defining neutrophil remodeling during aging and highlights candidate neutrophil states and potential signaling axes associated with age‐related inflammatory tissue environments. [ABSTRACT FROM AUTHOR] |
| Copyright of Aging Cell is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
| FullText | Links: – Type: other Text: Availability: 0 |
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| Header | DbId: edb DbLabel: Complementary Index An: 197990328 RelevancyScore: 1082 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1082.43029785156 |
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| Items | – Name: Title Label: Title Group: Ti Data: Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yuman%22">Wang, Yuman</searchLink><br /><searchLink fieldCode="AR" term="%22Chang%2C+Teding%22">Chang, Teding</searchLink><br /><searchLink fieldCode="AR" term="%22Fu%2C+Yangguang%22">Fu, Yangguang</searchLink><br /><searchLink fieldCode="AR" term="%22Liang%2C+Guangyu%22">Liang, Guangyu</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Huicheng%22">Liu, Huicheng</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Le%22">Zhang, Le</searchLink><br /><searchLink fieldCode="AR" term="%22Yan%2C+Jinhua%22">Yan, Jinhua</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Man%22">Liu, Man</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Anding%22">Liu, Anding</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Cuntai%22">Zhang, Cuntai</searchLink> – Name: TitleSource Label: Source Group: Src Data: Aging Cell; Oct2026, Vol. 25 Issue 10, p1-26, 26p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22Fibroblast+growth+factors%22">Fibroblast growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+sequencing%22">RNA sequencing</searchLink><br /><searchLink fieldCode="DE" term="%22Myeloid+cells%22">Myeloid cells</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aging is accompanied by progressive immune remodeling and functional decline across multiple organs. However, the role of neutrophils and their heterogeneous states in these processes remains incompletely understood. Here we integrated single‐cell RNA sequencing datasets from multiple organs of young and aged mice to characterize aging‐associated neutrophil remodeling. We identified organ‐dependent changes in neutrophil abundance and state composition, together with neutrophil subsets enriched for inflammatory, oxidative stress, complement, and IL‐6‐related transcriptional programs. In vitro, exposure to conditioned media from neutrophils isolated from aged mice or IL‐6‐stimulated neutrophil‐like cells increased inflammatory and senescence‐associated responses in vascular smooth muscle and hepatocyte‐derived cells. Bone marrow single‐cell analysis further revealed aging‐associated shifts in progenitor composition and transcriptional states, including an old‐enriched HPC11 population characterized by enhanced myeloid priming. Silico perturbation analysis nominated FGF didate regulators of HPC subtype‐specific transcriptional programs. Together, our study provides a multi‐organ single‐cell resource for defining neutrophil remodeling during aging and highlights candidate neutrophil states and potential signaling axes associated with age‐related inflammatory tissue environments. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Aging Cell is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/acel.70735 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 26 StartPage: 1 Subjects: – SubjectFull: Aging Type: general – SubjectFull: Interleukin-6 Type: general – SubjectFull: Fibroblast growth factors Type: general – SubjectFull: RNA sequencing Type: general – SubjectFull: Myeloid cells Type: general – SubjectFull: Inflammation Type: general Titles: – TitleFull: Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Yuman – PersonEntity: Name: NameFull: Chang, Teding – PersonEntity: Name: NameFull: Fu, Yangguang – PersonEntity: Name: NameFull: Liang, Guangyu – PersonEntity: Name: NameFull: Liu, Huicheng – PersonEntity: Name: NameFull: Zhang, Le – PersonEntity: Name: NameFull: Yan, Jinhua – PersonEntity: Name: NameFull: Liu, Man – PersonEntity: Name: NameFull: Liu, Anding – PersonEntity: Name: NameFull: Zhang, Cuntai IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 14749718 Numbering: – Type: volume Value: 25 – Type: issue Value: 10 Titles: – TitleFull: Aging Cell Type: main |
| ResultId | 1 |