Academic Journal

Epidermolytic Acanthomata on the Scrotum: A Enigmatic Entity With Human Papilloma Virus 52 Positivity.

Bibliographic Details
Title: Epidermolytic Acanthomata on the Scrotum: A Enigmatic Entity With Human Papilloma Virus 52 Positivity.
Authors: Vishwanath, Tejas, Mahajan, Sunanda, Gole, Prachi, Das, Surupa
Source: Journal of Cutaneous Pathology; Nov2026, Vol. 53 Issue 11, p986-989, 4p
Subject Terms: Human papillomavirus, Polymerase chain reaction, Genital warts, Skin diseases, Keratosis, Mutations (Algebra)
Abstract: We report the case of a 55‐year‐old male who presented with asymptomatic scrotal papules since 3–4 months. He had no comorbidities. Clinical differentials comprised genital verrucae and high‐grade squamous intraepithelial lesion (previously called bowenoid papulosis). Skin biopsy findings comprised perinuclear vacuolization of the stratum spinosum and granulosum, reticular degeneration, and coarse keratohyaline granules. These features were suggestive of epidermolytic acanthoma. Surprisingly, DNA PCR was positive for HPV52, a high‐risk HPV type, unlike previous case reports. Further research may be warranted on the pathogenesis, especially keratin 10 mutations and HPV positivity. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Epidermolytic Acanthomata on the Scrotum: A Enigmatic Entity With Human Papilloma Virus 52 Positivity.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Vishwanath%2C+Tejas%22">Vishwanath, Tejas</searchLink><br /><searchLink fieldCode="AR" term="%22Mahajan%2C+Sunanda%22">Mahajan, Sunanda</searchLink><br /><searchLink fieldCode="AR" term="%22Gole%2C+Prachi%22">Gole, Prachi</searchLink><br /><searchLink fieldCode="AR" term="%22Das%2C+Surupa%22">Das, Surupa</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Cutaneous Pathology; Nov2026, Vol. 53 Issue 11, p986-989, 4p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Human+papillomavirus%22">Human papillomavirus</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerase+chain+reaction%22">Polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Genital+warts%22">Genital warts</searchLink><br /><searchLink fieldCode="DE" term="%22Skin+diseases%22">Skin diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Keratosis%22">Keratosis</searchLink><br /><searchLink fieldCode="DE" term="%22Mutations+%28Algebra%29%22">Mutations (Algebra)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: We report the case of a 55‐year‐old male who presented with asymptomatic scrotal papules since 3–4 months. He had no comorbidities. Clinical differentials comprised genital verrucae and high‐grade squamous intraepithelial lesion (previously called bowenoid papulosis). Skin biopsy findings comprised perinuclear vacuolization of the stratum spinosum and granulosum, reticular degeneration, and coarse keratohyaline granules. These features were suggestive of epidermolytic acanthoma. Surprisingly, DNA PCR was positive for HPV52, a high‐risk HPV type, unlike previous case reports. Further research may be warranted on the pathogenesis, especially keratin 10 mutations and HPV positivity. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/cup.70130
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      – Code: eng
        Text: English
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        PageCount: 4
        StartPage: 986
    Subjects:
      – SubjectFull: Human papillomavirus
        Type: general
      – SubjectFull: Polymerase chain reaction
        Type: general
      – SubjectFull: Genital warts
        Type: general
      – SubjectFull: Skin diseases
        Type: general
      – SubjectFull: Keratosis
        Type: general
      – SubjectFull: Mutations (Algebra)
        Type: general
    Titles:
      – TitleFull: Epidermolytic Acanthomata on the Scrotum: A Enigmatic Entity With Human Papilloma Virus 52 Positivity.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Vishwanath, Tejas
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          Name:
            NameFull: Mahajan, Sunanda
      – PersonEntity:
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            NameFull: Gole, Prachi
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            NameFull: Das, Surupa
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          Dates:
            – D: 01
              M: 11
              Text: Nov2026
              Type: published
              Y: 2026
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              Value: 03036987
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              Value: 53
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              Value: 11
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            – TitleFull: Journal of Cutaneous Pathology
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