Academic Journal
Hijacking Host Communication: The Central Role of Extracellular Vesicles in Infectious Disease Pathogenesis.
| Τίτλος: | Hijacking Host Communication: The Central Role of Extracellular Vesicles in Infectious Disease Pathogenesis. |
|---|---|
| Συγγραφείς: | Santos, Patrick, Almeida, Fausto |
| Πηγή: | Cells (2073-4409); Sep2026, Vol. 15 Issue 18, p1708, 30p |
| Θεματικοί όροι: | Extracellular vesicles, Immunoregulation, Communicable diseases, Host-parasite relationships, Immunity |
| Περίληψη: | Highlights: What are the main findings? Extracellular vesicles constitute a conserved communication network that redefines host–pathogen interactions across infectious diseases. EV cargo integrates immune modulation, pathogen persistence, and tissue pathology through shared mechanisms across distinct pathogen kingdoms. What are the implications of the main findings? This review provides a unified cellular framework connecting EV biology from protozoan, viral, and bacterial infections. Targeting EV-mediated communication opens new opportunities for precision diagnostics, vaccines, and host-directed therapies. Extracellular vesicles (EVs) have emerged as fundamental mediators of intercellular communication during infectious diseases, acting as vehicles for proteins, lipids, and nucleic acids that profoundly influence host–pathogen interactions. In recent years, accumulating evidence has revealed that pathogens from distinct biological kingdoms, including protozoan parasites, viruses, and bacteria, either release their own EVs or exploit host-derived EVs to manipulate immune responses, promote infection, and sustain chronic disease. This review provides a comprehensive and integrative overview of the roles of EVs in infectious diseases, with particular emphasis on immune modulation, immune evasion, pathogenesis, and translational applications. We summarize current knowledge on EV-mediated communication in infections caused by major protozoan parasites (Trypanosoma cruzi, Plasmodium spp., Toxoplasma gondii, and Leishmania spp.), highlighting how parasite- and host-derived EVs regulate inflammatory responses, facilitate intracellular survival, and shape disease outcomes. We further examine viral infections, including HIV, HPV, HCV, and airborne respiratory viruses such as SARS-CoV-2, where EVs contribute to viral persistence, immune dysfunction, oncogenesis, and long-term sequelae. In addition, we discuss bacterial infections, focusing on Mycobacterium tuberculosis, Streptococcus pneumoniae, and Helicobacter pylori, illustrating how EVs can function both as vectors of virulence factors and as components of host defense mechanisms. Finally, we explore the emerging translational potential of EVs as non-invasive biomarkers for disease diagnosis and prognosis, as well as their application as therapeutic and vaccine platforms. By integrating findings across diverse pathogens, this review highlights extracellular vesicles as widely implicated and dynamic contributors of infectious disease biology and underscores their relevance as targets and tools for next-generation diagnostic and therapeutic strategies. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Hijacking Host Communication: The Central Role of Extracellular Vesicles in Infectious Disease Pathogenesis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Santos%2C+Patrick%22">Santos, Patrick</searchLink><br /><searchLink fieldCode="AR" term="%22Almeida%2C+Fausto%22">Almeida, Fausto</searchLink> – Name: TitleSource Label: Source Group: Src Data: Cells (2073-4409); Sep2026, Vol. 15 Issue 18, p1708, 30p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Extracellular+vesicles%22">Extracellular vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Communicable+diseases%22">Communicable diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Host-parasite+relationships%22">Host-parasite relationships</searchLink><br /><searchLink fieldCode="DE" term="%22Immunity%22">Immunity</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Highlights: What are the main findings? Extracellular vesicles constitute a conserved communication network that redefines host–pathogen interactions across infectious diseases. EV cargo integrates immune modulation, pathogen persistence, and tissue pathology through shared mechanisms across distinct pathogen kingdoms. What are the implications of the main findings? This review provides a unified cellular framework connecting EV biology from protozoan, viral, and bacterial infections. Targeting EV-mediated communication opens new opportunities for precision diagnostics, vaccines, and host-directed therapies. Extracellular vesicles (EVs) have emerged as fundamental mediators of intercellular communication during infectious diseases, acting as vehicles for proteins, lipids, and nucleic acids that profoundly influence host–pathogen interactions. In recent years, accumulating evidence has revealed that pathogens from distinct biological kingdoms, including protozoan parasites, viruses, and bacteria, either release their own EVs or exploit host-derived EVs to manipulate immune responses, promote infection, and sustain chronic disease. This review provides a comprehensive and integrative overview of the roles of EVs in infectious diseases, with particular emphasis on immune modulation, immune evasion, pathogenesis, and translational applications. We summarize current knowledge on EV-mediated communication in infections caused by major protozoan parasites (Trypanosoma cruzi, Plasmodium spp., Toxoplasma gondii, and Leishmania spp.), highlighting how parasite- and host-derived EVs regulate inflammatory responses, facilitate intracellular survival, and shape disease outcomes. We further examine viral infections, including HIV, HPV, HCV, and airborne respiratory viruses such as SARS-CoV-2, where EVs contribute to viral persistence, immune dysfunction, oncogenesis, and long-term sequelae. In addition, we discuss bacterial infections, focusing on Mycobacterium tuberculosis, Streptococcus pneumoniae, and Helicobacter pylori, illustrating how EVs can function both as vectors of virulence factors and as components of host defense mechanisms. Finally, we explore the emerging translational potential of EVs as non-invasive biomarkers for disease diagnosis and prognosis, as well as their application as therapeutic and vaccine platforms. By integrating findings across diverse pathogens, this review highlights extracellular vesicles as widely implicated and dynamic contributors of infectious disease biology and underscores their relevance as targets and tools for next-generation diagnostic and therapeutic strategies. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/cells15181708 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 30 StartPage: 1708 Subjects: – SubjectFull: Extracellular vesicles Type: general – SubjectFull: Immunoregulation Type: general – SubjectFull: Communicable diseases Type: general – SubjectFull: Host-parasite relationships Type: general – SubjectFull: Immunity Type: general Titles: – TitleFull: Hijacking Host Communication: The Central Role of Extracellular Vesicles in Infectious Disease Pathogenesis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Santos, Patrick – PersonEntity: Name: NameFull: Almeida, Fausto IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 09 Text: Sep2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20734409 Numbering: – Type: volume Value: 15 – Type: issue Value: 18 Titles: – TitleFull: Cells (2073-4409) Type: main |
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