Academic Journal
EVALUATION OF THE ANTI-DIABETIC EFFECTS OF TINOSPORA CORDIFOLIA LEAF EXTRACT ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN.
| Title: | EVALUATION OF THE ANTI-DIABETIC EFFECTS OF TINOSPORA CORDIFOLIA LEAF EXTRACT ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN. |
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| Authors: | Tony, D. Eswar, Teja, N. Pavan, Nadendla, Ramarao |
| Source: | International Journal of Zoology & Applied Biosciences; 2026, Vol. 11 Issue 5, p15-19, 5p |
| Subject Terms: | Tinospora cordifolia, Animal models of diabetes, Hypoglycemic agents, Plant metabolites, Glibenclamide, Glycemic control |
| Abstract: | This paper was designed to conduct a review of Tinospora as an anti-diabetic. The Streptozotocin made the rats become diabetic and Cordifolia leaf extract was used. Diabetes mellitus is a polygenic and multifaceted disorder of metabolism. Unconditional insulin deficiency condition, insulin insensitivity or insulin insensitivity. either of them which leads to homeostasis of glucose being disarmed and hyperglycemia ensues. This is attributed to the leaf Tinospora cordifolia extract having a good anti-diabetic effect, which is likely as it has a high anti-diabetic potential. In this study, one intraperitoneal was used to induce Wistar rats to diabetes. Streptozotocin (55mg/kg) injection, followed by 28 days oral (50 per cent). Test group which had ethanolic cordifolia leaf extract (300 mg/kg). The efficacy of the extract and the standard was compared using a four-group design 6-design. Glibenclamide (10 mg/kg) by following the variation in the fasting blood glucose and body weight after a week. The phytochemical characterization of the 50 percent ethanol extract revealed the existence of tannins, flavonoids and alkaloids. The result was obtained with the 300mg/kg at 28 days. Important decrease of level of blood glucose by 58.2% (P < 0.01). The extract has a significant restoration of body weight and normalization of metabolic in the group treated as well. Parameters, which prove the efficiency similar to the conventional medicine Glibenclamide. The paper concurs with this fact that the 50 percent ethanol extract of Tinospora cordifolia leaves have immense anti-diabetic effects and prevent loss of weight in STZ-induced. diabetic rats, which it has over its traditional use as a natural therapeutic agent in the management of diabetes. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Zoology & Applied Biosciences is the property of Rishan Publications and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| FullText | Text: Availability: 0 |
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| Header | DbId: edb DbLabel: Complementary Index An: 197313436 RelevancyScore: 1082 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1082.42749023438 |
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| Items | – Name: Title Label: Title Group: Ti Data: EVALUATION OF THE ANTI-DIABETIC EFFECTS OF TINOSPORA CORDIFOLIA LEAF EXTRACT ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tony%2C+D%2E+Eswar%22">Tony, D. Eswar</searchLink><br /><searchLink fieldCode="AR" term="%22Teja%2C+N%2E+Pavan%22">Teja, N. Pavan</searchLink><br /><searchLink fieldCode="AR" term="%22Nadendla%2C+Ramarao%22">Nadendla, Ramarao</searchLink> – Name: TitleSource Label: Source Group: Src Data: International Journal of Zoology & Applied Biosciences; 2026, Vol. 11 Issue 5, p15-19, 5p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Tinospora+cordifolia%22">Tinospora cordifolia</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+of+diabetes%22">Animal models of diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Hypoglycemic+agents%22">Hypoglycemic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+metabolites%22">Plant metabolites</searchLink><br /><searchLink fieldCode="DE" term="%22Glibenclamide%22">Glibenclamide</searchLink><br /><searchLink fieldCode="DE" term="%22Glycemic+control%22">Glycemic control</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This paper was designed to conduct a review of Tinospora as an anti-diabetic. The Streptozotocin made the rats become diabetic and Cordifolia leaf extract was used. Diabetes mellitus is a polygenic and multifaceted disorder of metabolism. Unconditional insulin deficiency condition, insulin insensitivity or insulin insensitivity. either of them which leads to homeostasis of glucose being disarmed and hyperglycemia ensues. This is attributed to the leaf Tinospora cordifolia extract having a good anti-diabetic effect, which is likely as it has a high anti-diabetic potential. In this study, one intraperitoneal was used to induce Wistar rats to diabetes. Streptozotocin (55mg/kg) injection, followed by 28 days oral (50 per cent). Test group which had ethanolic cordifolia leaf extract (300 mg/kg). The efficacy of the extract and the standard was compared using a four-group design 6-design. Glibenclamide (10 mg/kg) by following the variation in the fasting blood glucose and body weight after a week. The phytochemical characterization of the 50 percent ethanol extract revealed the existence of tannins, flavonoids and alkaloids. The result was obtained with the 300mg/kg at 28 days. Important decrease of level of blood glucose by 58.2% (P < 0.01). The extract has a significant restoration of body weight and normalization of metabolic in the group treated as well. Parameters, which prove the efficiency similar to the conventional medicine Glibenclamide. The paper concurs with this fact that the 50 percent ethanol extract of Tinospora cordifolia leaves have immense anti-diabetic effects and prevent loss of weight in STZ-induced. diabetic rats, which it has over its traditional use as a natural therapeutic agent in the management of diabetes. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of International Journal of Zoology & Applied Biosciences is the property of Rishan Publications and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.55126/ijzab.2026.v11.i05.003 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 15 Subjects: – SubjectFull: Tinospora cordifolia Type: general – SubjectFull: Animal models of diabetes Type: general – SubjectFull: Hypoglycemic agents Type: general – SubjectFull: Plant metabolites Type: general – SubjectFull: Glibenclamide Type: general – SubjectFull: Glycemic control Type: general Titles: – TitleFull: EVALUATION OF THE ANTI-DIABETIC EFFECTS OF TINOSPORA CORDIFOLIA LEAF EXTRACT ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tony, D. Eswar – PersonEntity: Name: NameFull: Teja, N. Pavan – PersonEntity: Name: NameFull: Nadendla, Ramarao IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2026 Type: published Y: 2026 Numbering: – Type: volume Value: 11 – Type: issue Value: 5 Titles: – TitleFull: International Journal of Zoology & Applied Biosciences Type: main |
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