Academic Journal
Target, silence, replace: a review on RNA-based drugs in modern medicine.
| Τίτλος: | Target, silence, replace: a review on RNA-based drugs in modern medicine. |
|---|---|
| Συγγραφείς: | Mundlia, Poonam, Singh, Suraj Pratap, Pothal, Pritiman, Thakur, Tanya, Kathuria, Reema, Maurya, Sudhanshu, Sharma, Akanksha, Goel, Honey, Pandey, Ankur, Ranawat, Pavitra, Singh, Gurpal, Barnwal, Ravi Pratap |
| Πηγή: | Frontiers in Cell & Developmental Biology; 2026, p1-35, 35p |
| Θεματικοί όροι: | Small interfering RNA, mRNA vaccines, RNA-binding proteins, Oligonucleotides, CRISPRs, RNA interference, Cancer treatment, Antisense RNA |
| Περίληψη: | RNA therapies have evolved into a revolutionary approach in contemporary medicine for treating various diseases by directly targeting RNA molecules engaged in disease pathogenesis. These therapeutic agents regulate biological processes through diverse mechanisms, including modulation of RNA function and gene expression. Medical applications of RNA are greatly enhanced by its structure, adaptability, and capacity for targeted binding. Among these traits is its ability to bind to certain molecules unique to those chemicals. RNA-based treatments have emerged from advancements in the production, modification, and cellular transport of RNA molecules. Several RNA drugs have been approved whereas some are under trial for few diseases. RNA therapeutics can function at the level of RNAs, DNAs and proteins. The evolution of mRNA vaccines during the COVID-19 epidemic emphasizes the exciting potential of RNA therapies in the treatment of diseases. This article provides a comprehensive overview of the several forms of RNA therapies, including small-interfering RNA (siRNA), messenger RNA (mRNA), and antisense-oligonucleotides (ASOs), together with information on their action mechanisms and delivery strategies that improve cellular absorption and shield RNA molecules from degradation. Further, CRISPR-based editing of the genome can be employed for modification of target RNA sequences for various disorders. Development of RNA aptamers have also been identified as pivotal RNA-therapeutic candidate. Additionally, we have explained mechanistic details and examples of drugs approved for RNA therapy. Emphasizing their potential to enhance patient outcomes and fulfil unmet medical requirements, we also highlight the clinical development of RNA therapies in treating cancer and other infectious diseases. [ABSTRACT FROM AUTHOR] |
| Copyright of Frontiers in Cell & Developmental Biology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Target, silence, replace: a review on RNA-based drugs in modern medicine. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mundlia%2C+Poonam%22">Mundlia, Poonam</searchLink><br /><searchLink fieldCode="AR" term="%22Singh%2C+Suraj+Pratap%22">Singh, Suraj Pratap</searchLink><br /><searchLink fieldCode="AR" term="%22Pothal%2C+Pritiman%22">Pothal, Pritiman</searchLink><br /><searchLink fieldCode="AR" term="%22Thakur%2C+Tanya%22">Thakur, Tanya</searchLink><br /><searchLink fieldCode="AR" term="%22Kathuria%2C+Reema%22">Kathuria, Reema</searchLink><br /><searchLink fieldCode="AR" term="%22Maurya%2C+Sudhanshu%22">Maurya, Sudhanshu</searchLink><br /><searchLink fieldCode="AR" term="%22Sharma%2C+Akanksha%22">Sharma, Akanksha</searchLink><br /><searchLink fieldCode="AR" term="%22Goel%2C+Honey%22">Goel, Honey</searchLink><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Ankur%22">Pandey, Ankur</searchLink><br /><searchLink fieldCode="AR" term="%22Ranawat%2C+Pavitra%22">Ranawat, Pavitra</searchLink><br /><searchLink fieldCode="AR" term="%22Singh%2C+Gurpal%22">Singh, Gurpal</searchLink><br /><searchLink fieldCode="AR" term="%22Barnwal%2C+Ravi+Pratap%22">Barnwal, Ravi Pratap</searchLink> – Name: TitleSource Label: Source Group: Src Data: Frontiers in Cell & Developmental Biology; 2026, p1-35, 35p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Small+interfering+RNA%22">Small interfering RNA</searchLink><br /><searchLink fieldCode="DE" term="%22mRNA+vaccines%22">mRNA vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22RNA-binding+proteins%22">RNA-binding proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Oligonucleotides%22">Oligonucleotides</searchLink><br /><searchLink fieldCode="DE" term="%22CRISPRs%22">CRISPRs</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+interference%22">RNA interference</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Antisense+RNA%22">Antisense RNA</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: RNA therapies have evolved into a revolutionary approach in contemporary medicine for treating various diseases by directly targeting RNA molecules engaged in disease pathogenesis. These therapeutic agents regulate biological processes through diverse mechanisms, including modulation of RNA function and gene expression. Medical applications of RNA are greatly enhanced by its structure, adaptability, and capacity for targeted binding. Among these traits is its ability to bind to certain molecules unique to those chemicals. RNA-based treatments have emerged from advancements in the production, modification, and cellular transport of RNA molecules. Several RNA drugs have been approved whereas some are under trial for few diseases. RNA therapeutics can function at the level of RNAs, DNAs and proteins. The evolution of mRNA vaccines during the COVID-19 epidemic emphasizes the exciting potential of RNA therapies in the treatment of diseases. This article provides a comprehensive overview of the several forms of RNA therapies, including small-interfering RNA (siRNA), messenger RNA (mRNA), and antisense-oligonucleotides (ASOs), together with information on their action mechanisms and delivery strategies that improve cellular absorption and shield RNA molecules from degradation. Further, CRISPR-based editing of the genome can be employed for modification of target RNA sequences for various disorders. Development of RNA aptamers have also been identified as pivotal RNA-therapeutic candidate. Additionally, we have explained mechanistic details and examples of drugs approved for RNA therapy. Emphasizing their potential to enhance patient outcomes and fulfil unmet medical requirements, we also highlight the clinical development of RNA therapies in treating cancer and other infectious diseases. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Frontiers in Cell & Developmental Biology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fcell.2026.1879681 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 35 StartPage: 1 Subjects: – SubjectFull: Small interfering RNA Type: general – SubjectFull: mRNA vaccines Type: general – SubjectFull: RNA-binding proteins Type: general – SubjectFull: Oligonucleotides Type: general – SubjectFull: CRISPRs Type: general – SubjectFull: RNA interference Type: general – SubjectFull: Cancer treatment Type: general – SubjectFull: Antisense RNA Type: general Titles: – TitleFull: Target, silence, replace: a review on RNA-based drugs in modern medicine. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mundlia, Poonam – PersonEntity: Name: NameFull: Singh, Suraj Pratap – PersonEntity: Name: NameFull: Pothal, Pritiman – PersonEntity: Name: NameFull: Thakur, Tanya – PersonEntity: Name: NameFull: Kathuria, Reema – PersonEntity: Name: NameFull: Maurya, Sudhanshu – PersonEntity: Name: NameFull: Sharma, Akanksha – PersonEntity: Name: NameFull: Goel, Honey – PersonEntity: Name: NameFull: Pandey, Ankur – PersonEntity: Name: NameFull: Ranawat, Pavitra – PersonEntity: Name: NameFull: Singh, Gurpal – PersonEntity: Name: NameFull: Barnwal, Ravi Pratap IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 09 Text: 2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2296634X Titles: – TitleFull: Frontiers in Cell & Developmental Biology Type: main |
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