Academic Journal
Sequential determination of total mercury followed by mercury speciation in whole blood using a novel automated inline sample preparation system with liquid chromatography coupled to ICP-MS.
| Τίτλος: | Sequential determination of total mercury followed by mercury speciation in whole blood using a novel automated inline sample preparation system with liquid chromatography coupled to ICP-MS. |
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| Συγγραφείς: | Pacer, Emily J., Palmer, Christopher D., Quarles, C. Derrick, Bohlim, Nick A., Sullivan, Patrick, Parsons, Patrick J. |
| Πηγή: | JAAS (Journal of Analytical Atomic Spectrometry); Sep2026, Vol. 41 Issue 9, p3112-3119, 8p |
| Θεματικοί όροι: | Inductively coupled plasma mass spectrometry, Mercury compounds, Biological monitoring, Chemical sample preparation, Volatization, Methylmercury, Analytical chemistry |
| Περίληψη: | Mercury (Hg) is a toxic metal commonly measured in whole blood. Hg toxicity is dependent on the chemical species, where exposure to methylmercury (MeHg) tends to be more harmful than inorganic Hg (iHg), i.e., Hg2+ or Hg0. Nonetheless, the analysis for both total Hg and Hg speciation in blood are important for environmental and clinical investigations. This work focuses on developing a validated, automated, fast, and reliable method for both total Hg and the separation of iHg and MeHg in whole blood within the same analytical system. The optional addition of vapor generation (VG) was investigated to explore the potential for lower detection limits with a total of four analysis modes in one automated system, i.e., total Hg without VG, total Hg with VG, Hg speciation without VG, and Hg speciation with VG. The method presented here uses a C18 column for the separation of the Hg species within ∼7 minutes. Each of the four analysis modes were evaluated for accuracy by analyzing NIST SRM 955c and 955d, and archived blood samples distributed in the New York State Department of Health (NYS DOH) Biomonitoring Proficiency Testing program for trace elements. While VG did not result in a lower method limit of detection (LOD), performance was deemed reasonable. The method LODs without VG in a low-level blood reference material were 0.8 µg L−1 and 0.7 µg L−1 for iHg and MeHg, respectively, compared to 1.3 µg L−1 and 0.8 µg L−1 with VG. [ABSTRACT FROM AUTHOR] |
| Copyright of JAAS (Journal of Analytical Atomic Spectrometry) is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:edb&genre=article&issn=02679477&ISBN=&volume=41&issue=9&date=20260901&spage=3112&pages=3112-3119&title=JAAS (Journal of Analytical Atomic Spectrometry)&atitle=Sequential%20determination%20of%20total%20mercury%20followed%20by%20mercury%20speciation%20in%20whole%20blood%20using%20a%20novel%20automated%20inline%20sample%20preparation%20system%20with%20liquid%20chromatography%20coupled%20to%20ICP-MS.&aulast=Pacer%2C%20Emily%20J.&id=DOI:10.1039/d5ja00360a Name: Full Text Finder (for New FTF UI) (ns324271) Category: fullText Text: Full Text Finder MouseOverText: Full Text Finder |
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| Header | DbId: edb DbLabel: Complementary Index An: 196693308 RelevancyScore: 1082 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1082.42749023438 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sequential determination of total mercury followed by mercury speciation in whole blood using a novel automated inline sample preparation system with liquid chromatography coupled to ICP-MS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pacer%2C+Emily+J%2E%22">Pacer, Emily J.</searchLink><br /><searchLink fieldCode="AR" term="%22Palmer%2C+Christopher+D%2E%22">Palmer, Christopher D.</searchLink><br /><searchLink fieldCode="AR" term="%22Quarles%2C+C%2E+Derrick%22">Quarles, C. Derrick</searchLink><br /><searchLink fieldCode="AR" term="%22Bohlim%2C+Nick+A%2E%22">Bohlim, Nick A.</searchLink><br /><searchLink fieldCode="AR" term="%22Sullivan%2C+Patrick%22">Sullivan, Patrick</searchLink><br /><searchLink fieldCode="AR" term="%22Parsons%2C+Patrick+J%2E%22">Parsons, Patrick J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: JAAS (Journal of Analytical Atomic Spectrometry); Sep2026, Vol. 41 Issue 9, p3112-3119, 8p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Inductively+coupled+plasma+mass+spectrometry%22">Inductively coupled plasma mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Mercury+compounds%22">Mercury compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+monitoring%22">Biological monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+sample+preparation%22">Chemical sample preparation</searchLink><br /><searchLink fieldCode="DE" term="%22Volatization%22">Volatization</searchLink><br /><searchLink fieldCode="DE" term="%22Methylmercury%22">Methylmercury</searchLink><br /><searchLink fieldCode="DE" term="%22Analytical+chemistry%22">Analytical chemistry</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Mercury (Hg) is a toxic metal commonly measured in whole blood. Hg toxicity is dependent on the chemical species, where exposure to methylmercury (MeHg) tends to be more harmful than inorganic Hg (iHg), i.e., Hg<superscript>2+</superscript> or Hg<superscript>0</superscript>. Nonetheless, the analysis for both total Hg and Hg speciation in blood are important for environmental and clinical investigations. This work focuses on developing a validated, automated, fast, and reliable method for both total Hg and the separation of iHg and MeHg in whole blood within the same analytical system. The optional addition of vapor generation (VG) was investigated to explore the potential for lower detection limits with a total of four analysis modes in one automated system, i.e., total Hg without VG, total Hg with VG, Hg speciation without VG, and Hg speciation with VG. The method presented here uses a C18 column for the separation of the Hg species within ∼7 minutes. Each of the four analysis modes were evaluated for accuracy by analyzing NIST SRM 955c and 955d, and archived blood samples distributed in the New York State Department of Health (NYS DOH) Biomonitoring Proficiency Testing program for trace elements. While VG did not result in a lower method limit of detection (LOD), performance was deemed reasonable. The method LODs without VG in a low-level blood reference material were 0.8 µg L<superscript>−1</superscript> and 0.7 µg L<superscript>−1</superscript> for iHg and MeHg, respectively, compared to 1.3 µg L<superscript>−1</superscript> and 0.8 µg L<superscript>−1</superscript> with VG. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of JAAS (Journal of Analytical Atomic Spectrometry) is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5ja00360a Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 3112 Subjects: – SubjectFull: Inductively coupled plasma mass spectrometry Type: general – SubjectFull: Mercury compounds Type: general – SubjectFull: Biological monitoring Type: general – SubjectFull: Chemical sample preparation Type: general – SubjectFull: Volatization Type: general – SubjectFull: Methylmercury Type: general – SubjectFull: Analytical chemistry Type: general Titles: – TitleFull: Sequential determination of total mercury followed by mercury speciation in whole blood using a novel automated inline sample preparation system with liquid chromatography coupled to ICP-MS. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pacer, Emily J. – PersonEntity: Name: NameFull: Palmer, Christopher D. – PersonEntity: Name: NameFull: Quarles, C. Derrick – PersonEntity: Name: NameFull: Bohlim, Nick A. – PersonEntity: Name: NameFull: Sullivan, Patrick – PersonEntity: Name: NameFull: Parsons, Patrick J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 02679477 Numbering: – Type: volume Value: 41 – Type: issue Value: 9 Titles: – TitleFull: JAAS (Journal of Analytical Atomic Spectrometry) Type: main |
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