Academic Journal
Computational modeling and experimental validation for developed non-hormonal in-situ reversible cervical contraceptive plugs.
| Τίτλος: | Computational modeling and experimental validation for developed non-hormonal in-situ reversible cervical contraceptive plugs. |
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| Συγγραφείς: | Basavaraj, Basappa Veerabhadraiah, Kunchakuri, Keerthana S., Krishnamurthy, Shwetha |
| Πηγή: | European Journal of Contraception & Reproductive Health Care; Aug2026, Vol. 31 Issue 4, p275-287, 13p |
| Θεματικοί όροι: | Spermicides, Copper oxide, Gelation, Controlled release drugs, Contraceptives, Glibenclamide, Contraception |
| Abstract (English): | Background: Contraception remains crucial for preventing unintended pregnancies and managing population growth. Reported side effects and limitation associated with hormonal contraceptives have driven increased research towards non-hormonal contraceptive options. Methods: The present study focused on formulating a novel, non-hormonal, in-situ reversible cervical plug containing spermicidal agents. The plug acts as a physical barrier blocking the sperm cells and combination of glibenclamide and nano-copper oxide (NCO) acts as a chemical spermicidal agent, instantly killing the sperm cells coming in contact. NCO was synthesised using a muffle furnace and characterised by particle size zeta potential. Surface morphology was studies using SEM and EDX. Results: The synthesised NCO had average particle sizes of 482.7 nm and revealed formation of regular polyhedral shapes in SEM images. Molecular docking showed superior binding affinity of glibenclamide (−9.8 kcal/mol) in comparison to nonoxynol-9. The cervical plug demonstrated rapid gelation within 3 min, sustained gel stability for 4 h, and 99% drug release in 16 min. Conclusions: Ex-vivo studies have confirmed sperm immobilisation and morphological changes. In-vivo studies achieved 100% contraception without mucosal irritation, and fertility was restored post study. Stability studies indicated robust formulation properties. The developed cervical plug offers a non-hormonal contraceptive option that is reversible, effective, and safe. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 避孕对于预防非意愿妊娠和控制人口增长具有重要意义。由于激素类避孕方法存在一定的不良反应和局限性, 近年来越来越多的研究聚焦于非激素避孕方法。 本研究旨在开发一种含杀精成分的新型非激素可逆宫颈原位避孕栓。该避孕栓可作为物理屏障阻止精子通过宫颈, 同时, 由格列本脲与纳米氧化铜(nano-copper oxide, NCO)组成的联合杀精体系作为化学屏障, 可迅速杀灭与其接触的精子。采用马弗炉法制备NCO, 并对其粒径和Zeta电位进行表征；采用扫描电子显微镜和能量色散X射线能谱对其表面形貌及元素组成进行分析。 合成的NCO平均粒径为482.7 nm, SEM图像显示其呈规则多面体结构。分子对接结果表明, 格列本脲与靶标的结合亲和力(−9.8 kcal/mol)优于壬苯醇醚-9。所制备的宫颈避孕栓可在3 min内迅速形成凝胶, 凝胶稳定性可维持4 h, 16 min内药物累计释放率达到99%。 离体实验表明, 该制剂能够使精子失去活动能力, 并引起形态学改变。体内实验显示, 该避孕栓避孕成功率达到100%, 且未引起黏膜刺激；研究结束后, 生育能力恢复正常。稳定性研究进一步证实, 该制剂具有良好的稳定性。本研究开发的宫颈避孕栓是一种可逆、有效且安全的非激素避孕方法, 为非激素避孕策略提供了一种具有应用前景的新选择。 [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: | Complementary Index |
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