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Sensitive and Spatially‐Resolved Electrochemiluminescence via Micropatterning.

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Τίτλος: Sensitive and Spatially‐Resolved Electrochemiluminescence via Micropatterning.
Συγγραφείς: Shao, Yuliang, Starikova, Tatiana, Xi, Mengzhen, Balli, Maria Vittoria, Sciuto, Emanuele Luigi, Giagu, Gabriele, Paratore, Vincenzo, Corsaro, Carmelo, Fazio, Enza, Conoci, Sabrina, Prodi, Luca, Valenti, Giovanni, Levkin, Pavel A.
Πηγή: Advanced Materials Interfaces; 7/7/2026, Vol. 13 Issue 13, p1-12, 12p
Θεματικοί όροι: Electrochemiluminescence, Gold electrodes, Biosensors, SARS-CoV-2, Immunoassay, Silica nanoparticles
Περίληψη: Electrochemiluminescence (ECL) biosensing offers high sensitivity and low background but remains limited by the lack of simple strategies for electrode patterning, signal confinement, and multiplexed detection. Here, we report a silica nanoparticle–based coating and photopatterning approach for gold electrodes that enables spatially resolved and multiplexed ECL detection. The resulting electrode architecture confines aqueous droplets to designated locations and supports localized ECL signal generation. Compared with bare gold electrodes, the modified surfaces exhibit up to a ten‐fold increase in ECL intensity, which correlates with reduced charge‐transfer resistance and improved electron‐transfer kinetics. The patterned electrodes are compatible with magnetic bead–based immunoassays and allow parallel ECL measurements from multiple spatially separated regions on a single chip. Multiplexed detection is demonstrated using the synthetic SARS‐CoV‐2 spike protein as a model analyte. This coating and patterning strategy provides a straightforward route to spatially resolved ECL electrodes and can be applied to multiplexed electrochemical and bioanalytical measurements where signal confinement and multiplexing are required. [ABSTRACT FROM AUTHOR]
Copyright of Advanced Materials Interfaces is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Sensitive and Spatially‐Resolved Electrochemiluminescence via Micropatterning.
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  Data: <searchLink fieldCode="AR" term="%22Shao%2C+Yuliang%22">Shao, Yuliang</searchLink><br /><searchLink fieldCode="AR" term="%22Starikova%2C+Tatiana%22">Starikova, Tatiana</searchLink><br /><searchLink fieldCode="AR" term="%22Xi%2C+Mengzhen%22">Xi, Mengzhen</searchLink><br /><searchLink fieldCode="AR" term="%22Balli%2C+Maria+Vittoria%22">Balli, Maria Vittoria</searchLink><br /><searchLink fieldCode="AR" term="%22Sciuto%2C+Emanuele+Luigi%22">Sciuto, Emanuele Luigi</searchLink><br /><searchLink fieldCode="AR" term="%22Giagu%2C+Gabriele%22">Giagu, Gabriele</searchLink><br /><searchLink fieldCode="AR" term="%22Paratore%2C+Vincenzo%22">Paratore, Vincenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Corsaro%2C+Carmelo%22">Corsaro, Carmelo</searchLink><br /><searchLink fieldCode="AR" term="%22Fazio%2C+Enza%22">Fazio, Enza</searchLink><br /><searchLink fieldCode="AR" term="%22Conoci%2C+Sabrina%22">Conoci, Sabrina</searchLink><br /><searchLink fieldCode="AR" term="%22Prodi%2C+Luca%22">Prodi, Luca</searchLink><br /><searchLink fieldCode="AR" term="%22Valenti%2C+Giovanni%22">Valenti, Giovanni</searchLink><br /><searchLink fieldCode="AR" term="%22Levkin%2C+Pavel+A%2E%22">Levkin, Pavel A.</searchLink>
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  Data: Advanced Materials Interfaces; 7/7/2026, Vol. 13 Issue 13, p1-12, 12p
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  Data: <searchLink fieldCode="DE" term="%22Electrochemiluminescence%22">Electrochemiluminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Gold+electrodes%22">Gold electrodes</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoassay%22">Immunoassay</searchLink><br /><searchLink fieldCode="DE" term="%22Silica+nanoparticles%22">Silica nanoparticles</searchLink>
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  Data: Electrochemiluminescence (ECL) biosensing offers high sensitivity and low background but remains limited by the lack of simple strategies for electrode patterning, signal confinement, and multiplexed detection. Here, we report a silica nanoparticle–based coating and photopatterning approach for gold electrodes that enables spatially resolved and multiplexed ECL detection. The resulting electrode architecture confines aqueous droplets to designated locations and supports localized ECL signal generation. Compared with bare gold electrodes, the modified surfaces exhibit up to a ten‐fold increase in ECL intensity, which correlates with reduced charge‐transfer resistance and improved electron‐transfer kinetics. The patterned electrodes are compatible with magnetic bead–based immunoassays and allow parallel ECL measurements from multiple spatially separated regions on a single chip. Multiplexed detection is demonstrated using the synthetic SARS‐CoV‐2 spike protein as a model analyte. This coating and patterning strategy provides a straightforward route to spatially resolved ECL electrodes and can be applied to multiplexed electrochemical and bioanalytical measurements where signal confinement and multiplexing are required. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Advanced Materials Interfaces is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Biosensors
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              Text: 7/7/2026
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