Academic Journal
Comparative assessment of left common iliac vein compression in patients with hypermobile Ehlers-Danlos syndrome, hypermobility spectrum disorder and healthy controls – A retrospective single-centre study.
| Τίτλος: | Comparative assessment of left common iliac vein compression in patients with hypermobile Ehlers-Danlos syndrome, hypermobility spectrum disorder and healthy controls – A retrospective single-centre study. |
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| Συγγραφείς: | Ogunlade, Samuel B., Brown, Dillon, Rozen, Todd, Lewis, Andrew R., Toskich, Beau B., Fairweather, DeLisa, Bruno, Katelyn A., Knight, Dacre, Devcic, Zlatko |
| Πηγή: | Phlebology; Jul2026, Vol. 41 Issue 6, p506-514, 9p |
| Θεματικοί όροι: | Risk assessment, Ehlers-Danlos syndrome, Iliac vein, T-test (Statistics), May-Thurner syndrome, Computed tomography, Paired comparisons (Mathematics), Retrospective studies, Disease prevalence, Chi-squared test, Relative medical risk, Descriptive statistics, Odds ratio, Intraclass correlation, Comparative studies, Digital image processing, Confidence intervals, Data analysis software, Joint instability, Inter-observer reliability, Disease risk factors, Disease complications |
| Περίληψη: | Objectives: Heritable connective tissue disorders (HCTDs), including hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobile spectrum disorder (HSD), have complex clinical manifestations, but the prevalence of left common iliac vein (LCIV) compression in these groups is not well known. This study aimed to compare the prevalence of significant LCIV compression in patients with hEDS, HSD, and healthy controls. Methods: This retrospective, IRB-approved, single-center study analyzed 109 patients (25 hEDS, 64 HSD, 20 controls) who underwent contrast-enhanced abdominal and pelvic CT imaging from 2020 to 2023. LCIV compression was measured on axial CT, with >50% luminal narrowing defined as significant. Statistical analyses included chi-square tests, odds ratios, and t -tests. Interrater reliability was evaluated using intraclass correlation coefficients. Results: Significant LCIV compression occurred in 68.0% of hEDS, 65.6% of HSD, and 35.0% of controls (p = 0.034). Both hEDS (p = 0.027) and HSD (p = 0.015) groups had significantly higher compression rates than controls, with no statistically significant difference between the two clinical groups (p = 0.831). Odds of compression were nearly fourfold greater in hEDS (OR 3.95) and HSD (OR 3.54) compared to controls. Conclusion: LCIV compression is significantly more prevalent in patients with hEDS and HSD than in healthy controls, warranting further investigation of its clinical significance. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: | Complementary Index |
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