Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
How APOE4 Interacts with Biological Sex and Cognitive Differences to Shape Cognitive Decline in Alzheimer's Disease. |
| Συγγραφείς: |
Kucukay, Naz |
| Πηγή: |
International Journal of High School Research; May2026, Vol. 8 Issue 9, p147-153, 7p |
| Θεματικοί όροι: |
Apolipoprotein E4, Gender differences (Psychology), Cognition disorders, Menopause, Estrogen, Hippocampus (Brain), Alzheimer's disease, Prefrontal cortex |
| Περίληψη: |
Alzheimer's disease (AD) is a neurodegenerative disorder that is the cause of around 70% of cases of dementia, affecting memory, thinking, and behavior. One of the most widely recognised genetic risk factors is the presence of the Apolipoprotein E epsilon 4 (APOE4) gene variant, which significantly impacts brain structure, cognitive decline, and inflammation within the brain. Growing literature proposes that sex differences - including different cognitive patterns, hormonal changes, and sex genes influence how the APOE4 gene affects the brain. This review explores how the APOE4 gene variant increases the risk of AD and how cognitive differences and biological sex influence this relationship. Previous studies have utilised functional Magnetic Resonance Imaging (fMRI) to focus on key brain regions and explore how APOE4 affects the hippocampus and prefrontal cortex, which are essential for memory and cognitive functions. Moreover, further research has considered how menopause and estrogen contribute to negative progression in women. This paper argues that sex based genetic and cognitive factors change how the APOE4 gene variant expresses itself in the brain, leading to differences in AD progression and symptoms. These findings can shape future research and guide upcoming clinical approaches and treatment strategies towards sex specific AD diagnosis. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: |
Complementary Index |