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Anti-Helicobacter pylori Activity of Quinolin-2-one/Chalcone Hybrids as Urease Inhibitors.

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Τίτλος: Anti-Helicobacter pylori Activity of Quinolin-2-one/Chalcone Hybrids as Urease Inhibitors.
Συγγραφείς: Alzahrani, Hayat Ali
Πηγή: Journal of Pure & Applied Microbiology; 2026, Vol. 20 Issue 2, p1552-1558, 7p
Θεματικοί όροι: Helicobacter pylori, Enzyme inhibitors, Drug resistance, Antibacterial agents, Quinolone antibacterial agents, Pharmaceutical chemistry, Molecules
Περίληψη: The present research explores the urease inhibitory potential of a designed set of quinoline-2-one/chalcone hybrid derivatives (4a-e). The biological assessment demonstrated that these molecules exhibit strong urease inhibition, with IC50 values ranging from 0.58-1.90 µM. Their inhibitory potency notably surpasses that of the reference compound, thiourea (IC50 = 21.50 µM). Within this series, compounds 4a, 4c, and 4e emerged as the most active inhibitors, displaying IC50 values of 0.93 ± 0.08 µM, 0.75 ± 0.06 µM, and 0.58 ± 0.04 µM, respectively. In addition, the anti-Helicobacter pylori potential of these hybrids was assessed against three metronidazole-resistant H. pylori strains using the disk diffusion technique. The outcomes revealed a strong association, indicating that methoxy-bearing analogs 4c and 4e identified as the most effective urease inhibitors also exhibited pronounced antibacterial action against H. pylori. Collectively, these observations underscore the promising dual therapeutic profile of this hybrid framework. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Pure & Applied Microbiology is the property of Dr. M. N. Khan and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Βάση Δεδομένων: Complementary Index
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  Data: Anti-Helicobacter pylori Activity of Quinolin-2-one/Chalcone Hybrids as Urease Inhibitors.
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  Data: <searchLink fieldCode="AR" term="%22Alzahrani%2C+Hayat+Ali%22">Alzahrani, Hayat Ali</searchLink>
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  Data: Journal of Pure & Applied Microbiology; 2026, Vol. 20 Issue 2, p1552-1558, 7p
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  Data: <searchLink fieldCode="DE" term="%22Helicobacter+pylori%22">Helicobacter pylori</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme+inhibitors%22">Enzyme inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance%22">Drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Quinolone+antibacterial+agents%22">Quinolone antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+chemistry%22">Pharmaceutical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Molecules%22">Molecules</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The present research explores the urease inhibitory potential of a designed set of quinoline-2-one/chalcone hybrid derivatives (4a-e). The biological assessment demonstrated that these molecules exhibit strong urease inhibition, with IC<subscript>50</subscript> values ranging from 0.58-1.90 µM. Their inhibitory potency notably surpasses that of the reference compound, thiourea (IC<subscript>50</subscript> = 21.50 µM). Within this series, compounds 4a, 4c, and 4e emerged as the most active inhibitors, displaying IC<subscript>50</subscript> values of 0.93 ± 0.08 µM, 0.75 ± 0.06 µM, and 0.58 ± 0.04 µM, respectively. In addition, the anti-Helicobacter pylori potential of these hybrids was assessed against three metronidazole-resistant H. pylori strains using the disk diffusion technique. The outcomes revealed a strong association, indicating that methoxy-bearing analogs 4c and 4e identified as the most effective urease inhibitors also exhibited pronounced antibacterial action against H. pylori. Collectively, these observations underscore the promising dual therapeutic profile of this hybrid framework. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Pure & Applied Microbiology is the property of Dr. M. N. Khan and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.22207/JPAM.20.2.44
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 1552
    Subjects:
      – SubjectFull: Helicobacter pylori
        Type: general
      – SubjectFull: Enzyme inhibitors
        Type: general
      – SubjectFull: Drug resistance
        Type: general
      – SubjectFull: Antibacterial agents
        Type: general
      – SubjectFull: Quinolone antibacterial agents
        Type: general
      – SubjectFull: Pharmaceutical chemistry
        Type: general
      – SubjectFull: Molecules
        Type: general
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      – TitleFull: Anti-Helicobacter pylori Activity of Quinolin-2-one/Chalcone Hybrids as Urease Inhibitors.
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            – D: 01
              M: 06
              Text: 2026
              Type: published
              Y: 2026
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