Academic Journal
Stem Cell Therapies for Gastrointestinal and Liver Diseases: Translational Barriers, Clinical Heterogeneity, and Future Directions.
| Title: | Stem Cell Therapies for Gastrointestinal and Liver Diseases: Translational Barriers, Clinical Heterogeneity, and Future Directions. |
|---|---|
| Authors: | Nikolaev, Georgi, Lozenov, Stefan, Konaktchieva, Marina, Arabadzhiev, Borislav, Vassileva, Ivelina, Sotirov, Radko, Konakchieva, Rossitza |
| Source: | Biomedicines; May2026, Vol. 14 Issue 5, p1102, 21p |
| Subject Terms: | Mesenchymal stem cells, Liver diseases, Organoids, Stem cell treatment, Induced pluripotent stem cells, Extracellular vesicles, Gastrointestinal diseases |
| Abstract: | Gastrointestinal and liver diseases remain major contributors to global morbidity and mortality, with limited options for curative or regenerative treatment. Innovative cell-based platforms for liver regeneration and treatment include advanced therapy medicinal products (ATMPs) based on mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and organoids produced by them, while cell-free systems like extracellular vesicles (EVs) offer a new approach to restore tissue function and homeostasis. This review summarizes key advances from 2020 to 2025 in the translational development of these platforms. MSCs have achieved clinical validation in perianal Crohn's disease and show encouraging antifibrotic and immunomodulatory effects in cirrhosis and acute-on-chronic liver failure. iPSC and iPSC-derived organoids now enable disease modeling and, in early trials, have shown direct epithelial repair. Emerging cell-free approaches based on EVs promise safer, scalable products. Despite rapid progress, challenges remain in potency standardization, manufacturing, and long-term efficacy assessment. International harmonization through the EMA, FDA, and PMDA frameworks is accelerating the translation of stem cell-based advanced therapy medicinal products. The integration of bioengineering, data science, and ethical governance will determine whether these regenerative approaches evolve into accessible standard-of-care interventions for gastrointestinal and hepatic diseases. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:edb&genre=article&issn=22279059&ISBN=&volume=14&issue=5&date=20260501&spage=1102&pages=1102-1122&title=Biomedicines&atitle=Stem%20Cell%20Therapies%20for%20Gastrointestinal%20and%20Liver%20Diseases%3A%20Translational%20Barriers%2C%20Clinical%20Heterogeneity%2C%20and%20Future%20Directions.&aulast=Nikolaev%2C%20Georgi&id=DOI:10.3390/biomedicines14051102 Name: Full Text Finder (for New FTF UI) (ns324271) Category: fullText Text: Full Text Finder MouseOverText: Full Text Finder |
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| Header | DbId: edb DbLabel: Complementary Index An: 194121444 RelevancyScore: 1061 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1060.76245117188 |
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| Items | – Name: Title Label: Title Group: Ti Data: Stem Cell Therapies for Gastrointestinal and Liver Diseases: Translational Barriers, Clinical Heterogeneity, and Future Directions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nikolaev%2C+Georgi%22">Nikolaev, Georgi</searchLink><br /><searchLink fieldCode="AR" term="%22Lozenov%2C+Stefan%22">Lozenov, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Konaktchieva%2C+Marina%22">Konaktchieva, Marina</searchLink><br /><searchLink fieldCode="AR" term="%22Arabadzhiev%2C+Borislav%22">Arabadzhiev, Borislav</searchLink><br /><searchLink fieldCode="AR" term="%22Vassileva%2C+Ivelina%22">Vassileva, Ivelina</searchLink><br /><searchLink fieldCode="AR" term="%22Sotirov%2C+Radko%22">Sotirov, Radko</searchLink><br /><searchLink fieldCode="AR" term="%22Konakchieva%2C+Rossitza%22">Konakchieva, Rossitza</searchLink> – Name: TitleSource Label: Source Group: Src Data: Biomedicines; May2026, Vol. 14 Issue 5, p1102, 21p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Mesenchymal+stem+cells%22">Mesenchymal stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+diseases%22">Liver diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Organoids%22">Organoids</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cell+treatment%22">Stem cell treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Induced+pluripotent+stem+cells%22">Induced pluripotent stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+vesicles%22">Extracellular vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+diseases%22">Gastrointestinal diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Gastrointestinal and liver diseases remain major contributors to global morbidity and mortality, with limited options for curative or regenerative treatment. Innovative cell-based platforms for liver regeneration and treatment include advanced therapy medicinal products (ATMPs) based on mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and organoids produced by them, while cell-free systems like extracellular vesicles (EVs) offer a new approach to restore tissue function and homeostasis. This review summarizes key advances from 2020 to 2025 in the translational development of these platforms. MSCs have achieved clinical validation in perianal Crohn's disease and show encouraging antifibrotic and immunomodulatory effects in cirrhosis and acute-on-chronic liver failure. iPSC and iPSC-derived organoids now enable disease modeling and, in early trials, have shown direct epithelial repair. Emerging cell-free approaches based on EVs promise safer, scalable products. Despite rapid progress, challenges remain in potency standardization, manufacturing, and long-term efficacy assessment. International harmonization through the EMA, FDA, and PMDA frameworks is accelerating the translation of stem cell-based advanced therapy medicinal products. The integration of bioengineering, data science, and ethical governance will determine whether these regenerative approaches evolve into accessible standard-of-care interventions for gastrointestinal and hepatic diseases. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/biomedicines14051102 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 21 StartPage: 1102 Subjects: – SubjectFull: Mesenchymal stem cells Type: general – SubjectFull: Liver diseases Type: general – SubjectFull: Organoids Type: general – SubjectFull: Stem cell treatment Type: general – SubjectFull: Induced pluripotent stem cells Type: general – SubjectFull: Extracellular vesicles Type: general – SubjectFull: Gastrointestinal diseases Type: general Titles: – TitleFull: Stem Cell Therapies for Gastrointestinal and Liver Diseases: Translational Barriers, Clinical Heterogeneity, and Future Directions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nikolaev, Georgi – PersonEntity: Name: NameFull: Lozenov, Stefan – PersonEntity: Name: NameFull: Konaktchieva, Marina – PersonEntity: Name: NameFull: Arabadzhiev, Borislav – PersonEntity: Name: NameFull: Vassileva, Ivelina – PersonEntity: Name: NameFull: Sotirov, Radko – PersonEntity: Name: NameFull: Konakchieva, Rossitza IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 22279059 Numbering: – Type: volume Value: 14 – Type: issue Value: 5 Titles: – TitleFull: Biomedicines Type: main |
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