Academic Journal
Polymer Nanoparticles in Medical Applications—Future Directions.
| Τίτλος: | Polymer Nanoparticles in Medical Applications—Future Directions. |
|---|---|
| Συγγραφείς: | Zawidlak-Węgrzyńska, Barbara, Rydz, Joanna |
| Πηγή: | Nanomaterials (2079-4991); May2026, Vol. 16 Issue 10, p630, 39p |
| Θεματικοί όροι: | Targeted drug delivery, Nanomedicine, Nanoparticles, Regenerative medicine, Drug delivery systems, Surfaces (Technology), Thermoresponsive polymers, Translational research |
| Περίληψη: | Polymer-based nanoparticle systems have emerged as a versatile platform for advancing precision medicine by enabling controlled, targeted, and multifunctional drug delivery. This narrative review synthesizes recent progress in the design, functionalization, and clinical translation of polymer-based nanoparticles, with a focused scope on drug delivery, diagnostics, theranostics, nanosponges, and regenerative medicine. Specifically, it highlights three key insights: (i) surface engineering strategies, including ligand conjugation and stealth coatings, substantially enhance targeting specificity and reduce off-target toxicity; (ii) stimulus-responsive polymers enable spatiotemporally controlled drug release, improving therapeutic outcomes in complex disease microenvironments; and (iii) integration with artificial intelligence (AI) supports the rational design of personalized nanomedicines based on patient-specific molecular profiles. The innovative nature of this review lies in its comprehensive approach, which combines material design parameters with clinical outcomes and the barriers to implementation. Despite significant progress, serious challenges remain, including scalable and reproducible manufacturing, regulatory harmonization, and comprehensive long-term biosafety assessment. In the future, the priority should be to develop reliable manufacturing processes, a harmonized regulatory framework, and data-driven, clinically validated design methodologies. Overall, polymer-based nanoparticles are poised to redefine targeted therapy, but their clinical impact will depend on bridging the gap between laboratory innovation and scalable, safe, and personalized medical applications. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Polymer Nanoparticles in Medical Applications—Future Directions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zawidlak-Węgrzyńska%2C+Barbara%22">Zawidlak-Węgrzyńska, Barbara</searchLink><br /><searchLink fieldCode="AR" term="%22Rydz%2C+Joanna%22">Rydz, Joanna</searchLink> – Name: TitleSource Label: Source Group: Src Data: Nanomaterials (2079-4991); May2026, Vol. 16 Issue 10, p630, 39p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Regenerative+medicine%22">Regenerative medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Surfaces+%28Technology%29%22">Surfaces (Technology)</searchLink><br /><searchLink fieldCode="DE" term="%22Thermoresponsive+polymers%22">Thermoresponsive polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Translational+research%22">Translational research</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Polymer-based nanoparticle systems have emerged as a versatile platform for advancing precision medicine by enabling controlled, targeted, and multifunctional drug delivery. This narrative review synthesizes recent progress in the design, functionalization, and clinical translation of polymer-based nanoparticles, with a focused scope on drug delivery, diagnostics, theranostics, nanosponges, and regenerative medicine. Specifically, it highlights three key insights: (i) surface engineering strategies, including ligand conjugation and stealth coatings, substantially enhance targeting specificity and reduce off-target toxicity; (ii) stimulus-responsive polymers enable spatiotemporally controlled drug release, improving therapeutic outcomes in complex disease microenvironments; and (iii) integration with artificial intelligence (AI) supports the rational design of personalized nanomedicines based on patient-specific molecular profiles. The innovative nature of this review lies in its comprehensive approach, which combines material design parameters with clinical outcomes and the barriers to implementation. Despite significant progress, serious challenges remain, including scalable and reproducible manufacturing, regulatory harmonization, and comprehensive long-term biosafety assessment. In the future, the priority should be to develop reliable manufacturing processes, a harmonized regulatory framework, and data-driven, clinically validated design methodologies. Overall, polymer-based nanoparticles are poised to redefine targeted therapy, but their clinical impact will depend on bridging the gap between laboratory innovation and scalable, safe, and personalized medical applications. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano16100630 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 39 StartPage: 630 Subjects: – SubjectFull: Targeted drug delivery Type: general – SubjectFull: Nanomedicine Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Regenerative medicine Type: general – SubjectFull: Drug delivery systems Type: general – SubjectFull: Surfaces (Technology) Type: general – SubjectFull: Thermoresponsive polymers Type: general – SubjectFull: Translational research Type: general Titles: – TitleFull: Polymer Nanoparticles in Medical Applications—Future Directions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zawidlak-Węgrzyńska, Barbara – PersonEntity: Name: NameFull: Rydz, Joanna IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 16 – Type: issue Value: 10 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |