Academic Journal
Biomechanical anticoagulation by spherical platelets in extracorporeal systems.
| Τίτλος: | Biomechanical anticoagulation by spherical platelets in extracorporeal systems. |
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| Συγγραφείς: | Ji, Rui, Li, Yongjian, Li, Jiang, Chen, Haosheng |
| Πηγή: | Proceedings of the National Academy of Sciences of the United States of America; 4/7/2026, Vol. 123 Issue 14, p1-10, 25p |
| Θεματικοί όροι: | Hemodialysis, Blood coagulation, Artificial blood circulation, Molecular dynamics, Mechanotransduction (Cytology), Anticoagulants, Integrins |
| Περίληψη: | Extracorporeal life support, such as hemodialysis, often face the risk of blood coagulation, where systemic anticoagulation with heparin is routinely administered. However, this strategy is contraindicated in patients at high risk of bleeding. Inspired by the observation that rolling motion of spherical platelets avoids their exposure to tangential forces, an anticoagulation strategy is proposed based on platelet spherification for extracorporeal systems. Experimental results prove that spherical platelets retain activation pathways and capacity compared to discoid platelets. Mechanical activation is driven by tangential rather than normal forces, and maintaining rolling instead of sliding effectively prevents tangential force-induced activation. Molecular dynamics simulations reveal that tangential force acting on sliding discoid platelets separates the integrin α |
| Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Βάση Δεδομένων: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Biomechanical anticoagulation by spherical platelets in extracorporeal systems. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ji%2C+Rui%22">Ji, Rui</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Yongjian%22">Li, Yongjian</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Jiang%22">Li, Jiang</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Haosheng%22">Chen, Haosheng</searchLink> – Name: TitleSource Label: Source Group: Src Data: Proceedings of the National Academy of Sciences of the United States of America; 4/7/2026, Vol. 123 Issue 14, p1-10, 25p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Hemodialysis%22">Hemodialysis</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation%22">Blood coagulation</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+blood+circulation%22">Artificial blood circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+dynamics%22">Molecular dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanotransduction+%28Cytology%29%22">Mechanotransduction (Cytology)</searchLink><br /><searchLink fieldCode="DE" term="%22Anticoagulants%22">Anticoagulants</searchLink><br /><searchLink fieldCode="DE" term="%22Integrins%22">Integrins</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Extracorporeal life support, such as hemodialysis, often face the risk of blood coagulation, where systemic anticoagulation with heparin is routinely administered. However, this strategy is contraindicated in patients at high risk of bleeding. Inspired by the observation that rolling motion of spherical platelets avoids their exposure to tangential forces, an anticoagulation strategy is proposed based on platelet spherification for extracorporeal systems. Experimental results prove that spherical platelets retain activation pathways and capacity compared to discoid platelets. Mechanical activation is driven by tangential rather than normal forces, and maintaining rolling instead of sliding effectively prevents tangential force-induced activation. Molecular dynamics simulations reveal that tangential force acting on sliding discoid platelets separates the integrin α<subscript>IIb</subscript>β<subscript>3</subscript> head from the lower leg region to unfold and activate the integrin, while the normal force acting on rolling spherical platelets induces headpiece rotation without triggering unfolding, which effectively reduces integrin α<subscript>IIb</subscript>β<subscript>3</subscript> activation. In in vitro hemodialysis experiments, platelet spherification effectively minimized coagulation, while avoiding bleeding complications. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2535113123 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 25 StartPage: 1 Subjects: – SubjectFull: Hemodialysis Type: general – SubjectFull: Blood coagulation Type: general – SubjectFull: Artificial blood circulation Type: general – SubjectFull: Molecular dynamics Type: general – SubjectFull: Mechanotransduction (Cytology) Type: general – SubjectFull: Anticoagulants Type: general – SubjectFull: Integrins Type: general Titles: – TitleFull: Biomechanical anticoagulation by spherical platelets in extracorporeal systems. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ji, Rui – PersonEntity: Name: NameFull: Li, Yongjian – PersonEntity: Name: NameFull: Li, Jiang – PersonEntity: Name: NameFull: Chen, Haosheng IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 04 Text: 4/7/2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00278424 Numbering: – Type: volume Value: 123 – Type: issue Value: 14 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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