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Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.

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Τίτλος: Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Συγγραφείς: Xia, Chen, Dai, Zhanqiu, Wang, Yongcheng, Yu, Jiachen, Wang, Zijie, Huang, Zhenxiang, Pan, Kaifeng, Yang, Ke, Chen, Yiyu, Zhong, Peiyu, Gu, Chenhui, Fan, Shunwu, Lin, Xianfeng, Chen, Pengfei
Πηγή: Nature Communications; 3/31/2026, Vol. 17 Issue 1, p1-22, 22p
Θεματικοί όροι: Homeostasis, Organelles, Physiological stress, Photosynthetic reaction centers, Photosynthesis, Animal cell biotechnology, Chloroplasts, Mitochondrial pathology
Περίληψη: Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Compared with animal cells, the participation of chloroplasts enables plant cells to show defensive adaptation under stress. Therefore, delivering plant-derived photosynthetic systems into animal cells may help to establish a more stable organelle interaction network. Here, we show that plant-derived photosynthetic systems can effectively restore homeostasis of the interaction network of animal organelles. Specifically, plant-derived nanothylakoid units provide energy to animal cells, regulate intracellular Ca2+ homeostasis, increase endoplasmic reticulum (ER) lipid unsaturation and global membrane fluidity, reduce abnormal contact between mitochondria and ER, and alleviate mitochondrial dysfunction. By combining implantable light-emitting diodes with wireless charging, we expand photosynthesis therapy, enabling treatments for deeper tissues. This study provides a proof-of-concept for disease treatment based on the regulation of organelle interaction networks by natural photosynthetic systems and establishes a therapeutic approach for treating deep tissues. Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems. [ABSTRACT FROM AUTHOR]
Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Βάση Δεδομένων: Complementary Index
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  – Url: https://dx.doi.org/doi:10.1038/s41467-026-69825-y
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  Data: Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
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  Data: <searchLink fieldCode="AR" term="%22Xia%2C+Chen%22">Xia, Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Dai%2C+Zhanqiu%22">Dai, Zhanqiu</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yongcheng%22">Wang, Yongcheng</searchLink><br /><searchLink fieldCode="AR" term="%22Yu%2C+Jiachen%22">Yu, Jiachen</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Zijie%22">Wang, Zijie</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Zhenxiang%22">Huang, Zhenxiang</searchLink><br /><searchLink fieldCode="AR" term="%22Pan%2C+Kaifeng%22">Pan, Kaifeng</searchLink><br /><searchLink fieldCode="AR" term="%22Yang%2C+Ke%22">Yang, Ke</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Yiyu%22">Chen, Yiyu</searchLink><br /><searchLink fieldCode="AR" term="%22Zhong%2C+Peiyu%22">Zhong, Peiyu</searchLink><br /><searchLink fieldCode="AR" term="%22Gu%2C+Chenhui%22">Gu, Chenhui</searchLink><br /><searchLink fieldCode="AR" term="%22Fan%2C+Shunwu%22">Fan, Shunwu</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Xianfeng%22">Lin, Xianfeng</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Pengfei%22">Chen, Pengfei</searchLink>
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  Data: Nature Communications; 3/31/2026, Vol. 17 Issue 1, p1-22, 22p
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  Data: <searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Organelles%22">Organelles</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+stress%22">Physiological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Photosynthetic+reaction+centers%22">Photosynthetic reaction centers</searchLink><br /><searchLink fieldCode="DE" term="%22Photosynthesis%22">Photosynthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+cell+biotechnology%22">Animal cell biotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22Chloroplasts%22">Chloroplasts</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondrial+pathology%22">Mitochondrial pathology</searchLink>
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  Data: Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Compared with animal cells, the participation of chloroplasts enables plant cells to show defensive adaptation under stress. Therefore, delivering plant-derived photosynthetic systems into animal cells may help to establish a more stable organelle interaction network. Here, we show that plant-derived photosynthetic systems can effectively restore homeostasis of the interaction network of animal organelles. Specifically, plant-derived nanothylakoid units provide energy to animal cells, regulate intracellular Ca<superscript>2+</superscript> homeostasis, increase endoplasmic reticulum (ER) lipid unsaturation and global membrane fluidity, reduce abnormal contact between mitochondria and ER, and alleviate mitochondrial dysfunction. By combining implantable light-emitting diodes with wireless charging, we expand photosynthesis therapy, enabling treatments for deeper tissues. This study provides a proof-of-concept for disease treatment based on the regulation of organelle interaction networks by natural photosynthetic systems and establishes a therapeutic approach for treating deep tissues. Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1038/s41467-026-69825-y
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        Text: English
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      – SubjectFull: Animal cell biotechnology
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