Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network. |
| Συγγραφείς: |
Xia, Chen, Dai, Zhanqiu, Wang, Yongcheng, Yu, Jiachen, Wang, Zijie, Huang, Zhenxiang, Pan, Kaifeng, Yang, Ke, Chen, Yiyu, Zhong, Peiyu, Gu, Chenhui, Fan, Shunwu, Lin, Xianfeng, Chen, Pengfei |
| Πηγή: |
Nature Communications; 3/31/2026, Vol. 17 Issue 1, p1-22, 22p |
| Θεματικοί όροι: |
Homeostasis, Organelles, Physiological stress, Photosynthetic reaction centers, Photosynthesis, Animal cell biotechnology, Chloroplasts, Mitochondrial pathology |
| Περίληψη: |
Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Compared with animal cells, the participation of chloroplasts enables plant cells to show defensive adaptation under stress. Therefore, delivering plant-derived photosynthetic systems into animal cells may help to establish a more stable organelle interaction network. Here, we show that plant-derived photosynthetic systems can effectively restore homeostasis of the interaction network of animal organelles. Specifically, plant-derived nanothylakoid units provide energy to animal cells, regulate intracellular Ca2+ homeostasis, increase endoplasmic reticulum (ER) lipid unsaturation and global membrane fluidity, reduce abnormal contact between mitochondria and ER, and alleviate mitochondrial dysfunction. By combining implantable light-emitting diodes with wireless charging, we expand photosynthesis therapy, enabling treatments for deeper tissues. This study provides a proof-of-concept for disease treatment based on the regulation of organelle interaction networks by natural photosynthetic systems and establishes a therapeutic approach for treating deep tissues. Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: |
Complementary Index |