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Altered frequency architecture of spontaneous brain activity in asymptomatic carotid stenosis: a wavelet-based resting-state fMRI study.

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Τίτλος: Altered frequency architecture of spontaneous brain activity in asymptomatic carotid stenosis: a wavelet-based resting-state fMRI study.
Συγγραφείς: Xue, Wei, Qin, Zongyuan, Zhong, Xiaoli, An, Liangliang, Shi, Hanming, Wang, Haifeng, Wang, Jinjun, Gao, Lei, Zhao, Yang
Πηγή: Frontiers in Neurology; 2026, p1-14, 14p
Θεματικοί όροι: Carotid artery stenosis, Default mode network, Cognition disorders, Brain waves, Wavelets (Mathematics), Functional magnetic resonance imaging
Περίληψη: The intrinsic brain activity measured by resting-state fMRI (rs-fMRI) consists of synchronized neural oscillations across a broad range of low frequencies. Although previous studies have linked frequency-specific changes to cognitive function and impairment, the alterations of these frequency-specific spatiotemporal patterns in chronic occlusive cerebrovascular disease remain unclear. In this study, we investigated the cross-frequency structure underlying cognitive impairment in patients with severe asymptomatic carotid stenosis (SACS) using wavelet-transformed amplitude of low-frequency fluctuation (wavelet-ALFF) of rs-fMRI. We found that, in healthy controls, frequency-specific wavelet-ALFF exhibited a spatial distribution from lower to higher frequencies, aligned with the functional hierarchy extending from the default mode network (DMN) to primary somatomotor and subcortical regions. In contrast, SACS patients exhibited frequency-dependent changes, including significantly decreased wavelet-ALFF in the anteromedial DMN at lower frequencies and the posteromedial DMN at higher frequencies. Further spatiotemporal decomposition analysis revealed that SACS patients exhibited abnormal cross-frequency coupling in the DMN. Our findings suggest that frequency-specific changes underlying cognitive impairment in SACS arise from spatiotemporally abnormal cross-frequency interplay within the DMN. These insights may contribute to a better understanding of other major brain diseases. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Neurology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Βάση Δεδομένων: Complementary Index
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  Data: Altered frequency architecture of spontaneous brain activity in asymptomatic carotid stenosis: a wavelet-based resting-state fMRI study.
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  Data: Frontiers in Neurology; 2026, p1-14, 14p
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  Data: <searchLink fieldCode="DE" term="%22Carotid+artery+stenosis%22">Carotid artery stenosis</searchLink><br /><searchLink fieldCode="DE" term="%22Default+mode+network%22">Default mode network</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+waves%22">Brain waves</searchLink><br /><searchLink fieldCode="DE" term="%22Wavelets+%28Mathematics%29%22">Wavelets (Mathematics)</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The intrinsic brain activity measured by resting-state fMRI (rs-fMRI) consists of synchronized neural oscillations across a broad range of low frequencies. Although previous studies have linked frequency-specific changes to cognitive function and impairment, the alterations of these frequency-specific spatiotemporal patterns in chronic occlusive cerebrovascular disease remain unclear. In this study, we investigated the cross-frequency structure underlying cognitive impairment in patients with severe asymptomatic carotid stenosis (SACS) using wavelet-transformed amplitude of low-frequency fluctuation (wavelet-ALFF) of rs-fMRI. We found that, in healthy controls, frequency-specific wavelet-ALFF exhibited a spatial distribution from lower to higher frequencies, aligned with the functional hierarchy extending from the default mode network (DMN) to primary somatomotor and subcortical regions. In contrast, SACS patients exhibited frequency-dependent changes, including significantly decreased wavelet-ALFF in the anteromedial DMN at lower frequencies and the posteromedial DMN at higher frequencies. Further spatiotemporal decomposition analysis revealed that SACS patients exhibited abnormal cross-frequency coupling in the DMN. Our findings suggest that frequency-specific changes underlying cognitive impairment in SACS arise from spatiotemporally abnormal cross-frequency interplay within the DMN. These insights may contribute to a better understanding of other major brain diseases. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Neurology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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