IDENTIFICATION OF AGE-RELATED HUB GENES IN HEPATITIS B-ASSOCIATED HEPATOCELLULAR CARCINOMA THROUGH TRANSCRIPTOMIC ANALYSIS: INSIGHTS INTO PROGNOSTIC BIOMARKERS AND VACCINE DEVELOPMENT.

Bibliographic Details
Title:	IDENTIFICATION OF AGE-RELATED HUB GENES IN HEPATITIS B-ASSOCIATED HEPATOCELLULAR CARCINOMA THROUGH TRANSCRIPTOMIC ANALYSIS: INSIGHTS INTO PROGNOSTIC BIOMARKERS AND VACCINE DEVELOPMENT.
Authors:	ANANTH, SANDHYA, SEN, DEBALINA, ALEX, AROCKIA
Source:	TPM: Testing, Psychometrics, Methodology in Applied Psychology; 2025 Supplement, Vol. 32, p502-526, 25p
Subject Terms:	Hepatocellular carcinoma, Hepatitis B, Individualized medicine, Prognosis, Transcriptomes, Genes, Genetic regulation, Vaccine development
Abstract:	Hepatocellular carcinoma (HCC) continues to pose a considerable worldwide health challenge, especially in areas with elevated Hepatitis B Virus (HBV) incidence. Notwithstanding progress in immunization and antiviral therapies, chronic HBV carriers continue to face danger. The genetic diversity of HCC requires the discovery of new prognostic biomarkers and therapeutic targets. This research investigates age-related hub genes in HBV-related hepatocellular carcinoma by transcriptome analysis. Gene expression data from GEO (GSE45267 and GSE38941) were examined to detect differentially expressed genes (DEGs) with GEO2R, then constructing a protein-protein interaction (PPI) network through STRING and Cytoscape. Functional enrichment and survival studies were conducted with GO, KEGG, UALCAN, GEPIA, and KM plotter. We discovered 1,322 differentially expressed genes (DEGs) in HBV samples and 249 overlapping DEGs in both young and elderly hepatocellular carcinoma (HCC) patients. PPI study identified significant hub genes: SYK, C3, CD44, IGLL5 (associated with HBV) and CDK1, UBE2C, BUB1B, CCNB1, CDC20, CCNA2, MAD2L1, BIRC5 (associated with HCC). These genes participate in immune response, metabolism, and tumour growth, with increased expression associated with worse prognosis. Our research elucidates essential molecular pathways linked with HBV-related HCC and aging-related tumour biology, pinpointing prospective biomarkers and therapeutic targets for precision medicine and vaccine innovation. [ABSTRACT FROM AUTHOR]
	Copyright of TPM: Testing, Psychometrics, Methodology in Applied Psychology is the property of CISES Srl and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Complementary Index

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Header	DbId: edb DbLabel: Complementary Index An: 188538467 RelevancyScore: 1007 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1007.33099365234
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Items	– Name: Title Label: Title Group: Ti Data: IDENTIFICATION OF AGE-RELATED HUB GENES IN HEPATITIS B-ASSOCIATED HEPATOCELLULAR CARCINOMA THROUGH TRANSCRIPTOMIC ANALYSIS: INSIGHTS INTO PROGNOSTIC BIOMARKERS AND VACCINE DEVELOPMENT. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22ANANTH%2C+SANDHYA%22">ANANTH, SANDHYA</searchLink><br /><searchLink fieldCode="AR" term="%22SEN%2C+DEBALINA%22">SEN, DEBALINA</searchLink><br /><searchLink fieldCode="AR" term="%22ALEX%2C+AROCKIA%22">ALEX, AROCKIA</searchLink> – Name: TitleSource Label: Source Group: Src Data: TPM: Testing, Psychometrics, Methodology in Applied Psychology; 2025 Supplement, Vol. 32, p502-526, 25p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Hepatocellular+carcinoma%22">Hepatocellular carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+B%22">Hepatitis B</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+medicine%22">Individualized medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Transcriptomes%22">Transcriptomes</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+regulation%22">Genetic regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccine+development%22">Vaccine development</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Hepatocellular carcinoma (HCC) continues to pose a considerable worldwide health challenge, especially in areas with elevated Hepatitis B Virus (HBV) incidence. Notwithstanding progress in immunization and antiviral therapies, chronic HBV carriers continue to face danger. The genetic diversity of HCC requires the discovery of new prognostic biomarkers and therapeutic targets. This research investigates age-related hub genes in HBV-related hepatocellular carcinoma by transcriptome analysis. Gene expression data from GEO (GSE45267 and GSE38941) were examined to detect differentially expressed genes (DEGs) with GEO2R, then constructing a protein-protein interaction (PPI) network through STRING and Cytoscape. Functional enrichment and survival studies were conducted with GO, KEGG, UALCAN, GEPIA, and KM plotter. We discovered 1,322 differentially expressed genes (DEGs) in HBV samples and 249 overlapping DEGs in both young and elderly hepatocellular carcinoma (HCC) patients. PPI study identified significant hub genes: SYK, C3, CD44, IGLL5 (associated with HBV) and CDK1, UBE2C, BUB1B, CCNB1, CDC20, CCNA2, MAD2L1, BIRC5 (associated with HCC). These genes participate in immune response, metabolism, and tumour growth, with increased expression associated with worse prognosis. Our research elucidates essential molecular pathways linked with HBV-related HCC and aging-related tumour biology, pinpointing prospective biomarkers and therapeutic targets for precision medicine and vaccine innovation. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of TPM: Testing, Psychometrics, Methodology in Applied Psychology is the property of CISES Srl and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo	BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 25 StartPage: 502 Subjects: – SubjectFull: Hepatocellular carcinoma Type: general – SubjectFull: Hepatitis B Type: general – SubjectFull: Individualized medicine Type: general – SubjectFull: Prognosis Type: general – SubjectFull: Transcriptomes Type: general – SubjectFull: Genes Type: general – SubjectFull: Genetic regulation Type: general – SubjectFull: Vaccine development Type: general Titles: – TitleFull: IDENTIFICATION OF AGE-RELATED HUB GENES IN HEPATITIS B-ASSOCIATED HEPATOCELLULAR CARCINOMA THROUGH TRANSCRIPTOMIC ANALYSIS: INSIGHTS INTO PROGNOSTIC BIOMARKERS AND VACCINE DEVELOPMENT. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: ANANTH, SANDHYA – PersonEntity: Name: NameFull: SEN, DEBALINA – PersonEntity: Name: NameFull: ALEX, AROCKIA IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 06 Text: 2025 Supplement Type: published Y: 2025 Identifiers: – Type: issn-print Value: 19726325 Numbering: – Type: volume Value: 32 Titles: – TitleFull: TPM: Testing, Psychometrics, Methodology in Applied Psychology Type: main
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