Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Molecular landscape and clinical outcome of SRSF2/TET2 Co-mutated myeloid neoplasms. |
| Συγγραφείς: |
Cockey, Samuel G., Zhang, Hailing, Hussaini, Mohammed, Zhang, Ling, Moscinski, Lynn, Yang, Ethan, Li, Julie, Wang, Le, Song, Jinming |
| Πηγή: |
Leukemia & Lymphoma; Mar2025, Vol. 66 Issue 3, p469-478, 10p |
| Θεματικοί όροι: |
Treatment effectiveness, Chronic leukemia, Myeloproliferative neoplasms, Overall survival, Myelodysplastic syndromes |
| Περίληψη: |
The mutations in SRSF2 and TET2 genes are frequently present in various myeloid neoplasms. The potential impact of SRSF2/TET2 co-mutations on patient survival is incompletely understood. We identified 412 patients with SRSF2/TET2 co-mutations from our NextGen sequencing database of around 8000 patients and reported likely the largest cohort study. Our study demonstrated the presence of these co-mutations in a spectrum of myeloid neoplasms, which show different genetic and molecular characteristics. Most of the patients with these co-mutations had normal karyotype. Interestingly, our study provided insights into the prevalence of additional mutations such as ASXL1, RUNX1, and KRAS with this co-mutation and their potential impact on patients' prognosis. We found that ASXL1, RUNX1, and KRAS can negatively impact these patients' survival with different impacts in different morphological diagnosis categories, suggesting a complex interaction between these genes. This study underscores the need for personalized approaches in the treatment of myeloid neoplasms. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: |
Complementary Index |