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Development of a pH‐strip‐based sensor for the detection of ammonia in exhaled breath as a promising method for the diagnosis of Helicobacter pylori infections.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Development of a pH‐strip‐based sensor for the detection of ammonia in exhaled breath as a promising method for the diagnosis of Helicobacter pylori infections.
Συγγραφείς: Tsai, Ming‐Chang, Wang, Chi‐Chih, Chung, Hsieh‐Hsunh, Hsieh, Ping‐His, Tsai, Hwei‐Yan
Πηγή: Journal of the Chinese Chemical Society; Sep2024, Vol. 71 Issue 9, p1103-1110, 8p
Θεματικοί όροι: Helicobacter pylori infections, Fish spoilage, Ammonia gas, Helicobacter pylori, Gastrointestinal diseases
Περίληψη: The early detection and treatment of Helicobacter pylori infections can help prevent the formation of ulcers and development of gastric cancer in humans. The urea breath test (UBT) is a noninvasive test for diagnosing H. pylori. However, isotopic‐labeled UBT reagents are expensive and require specialized test equipment to detect isotopic CO2. In this study, the development of a user‐friendly, cost‐effective, and alternative method for diagnosing H. pylori infections by detecting NH3 in exhaled breath is reported. A commercial disposable pH strip is modified with sodium carboxymethylcellulose to enhance its performance in gaseous environments. The modified pH strip exhibits compatibility with both acidic (HCl and CH3COOH) and alkaline (NH3) gases. Furthermore, the sensor monitors the production of NH3 resulting from fish spoilage for 72 h, highlighting its real‐time capabilities. The feasibility of employing this simple strip sensor to detect H. pylori infection in patients is investigated through in vitro experiments and preliminary clinical studies. The simple strip sensor is a promising alternative to the C‐13 UBT for detecting H. pylori infection. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the Chinese Chemical Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Development of a pH‐strip‐based sensor for the detection of ammonia in exhaled breath as a promising method for the diagnosis of Helicobacter pylori infections.
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  Data: <searchLink fieldCode="AR" term="%22Tsai%2C+Ming‐Chang%22">Tsai, Ming‐Chang</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Chi‐Chih%22">Wang, Chi‐Chih</searchLink><br /><searchLink fieldCode="AR" term="%22Chung%2C+Hsieh‐Hsunh%22">Chung, Hsieh‐Hsunh</searchLink><br /><searchLink fieldCode="AR" term="%22Hsieh%2C+Ping‐His%22">Hsieh, Ping‐His</searchLink><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Hwei‐Yan%22">Tsai, Hwei‐Yan</searchLink>
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  Data: Journal of the Chinese Chemical Society; Sep2024, Vol. 71 Issue 9, p1103-1110, 8p
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  Data: <searchLink fieldCode="DE" term="%22Helicobacter+pylori+infections%22">Helicobacter pylori infections</searchLink><br /><searchLink fieldCode="DE" term="%22Fish+spoilage%22">Fish spoilage</searchLink><br /><searchLink fieldCode="DE" term="%22Ammonia+gas%22">Ammonia gas</searchLink><br /><searchLink fieldCode="DE" term="%22Helicobacter+pylori%22">Helicobacter pylori</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+diseases%22">Gastrointestinal diseases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The early detection and treatment of Helicobacter pylori infections can help prevent the formation of ulcers and development of gastric cancer in humans. The urea breath test (UBT) is a noninvasive test for diagnosing H. pylori. However, isotopic‐labeled UBT reagents are expensive and require specialized test equipment to detect isotopic CO2. In this study, the development of a user‐friendly, cost‐effective, and alternative method for diagnosing H. pylori infections by detecting NH3 in exhaled breath is reported. A commercial disposable pH strip is modified with sodium carboxymethylcellulose to enhance its performance in gaseous environments. The modified pH strip exhibits compatibility with both acidic (HCl and CH3COOH) and alkaline (NH3) gases. Furthermore, the sensor monitors the production of NH3 resulting from fish spoilage for 72 h, highlighting its real‐time capabilities. The feasibility of employing this simple strip sensor to detect H. pylori infection in patients is investigated through in vitro experiments and preliminary clinical studies. The simple strip sensor is a promising alternative to the C‐13 UBT for detecting H. pylori infection. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the Chinese Chemical Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/jccs.202400093
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      – Code: eng
        Text: English
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        PageCount: 8
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      – SubjectFull: Helicobacter pylori infections
        Type: general
      – SubjectFull: Fish spoilage
        Type: general
      – SubjectFull: Ammonia gas
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      – SubjectFull: Helicobacter pylori
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      – SubjectFull: Gastrointestinal diseases
        Type: general
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      – TitleFull: Development of a pH‐strip‐based sensor for the detection of ammonia in exhaled breath as a promising method for the diagnosis of Helicobacter pylori infections.
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            – D: 01
              M: 09
              Text: Sep2024
              Type: published
              Y: 2024
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