Academic Journal
Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications.
| Title: | Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications. |
|---|---|
| Authors: | Kolmanovich, Danil D., Chukavin, Nikita N., Savintseva, Irina V., Mysina, Elena A., Popova, Nelli R., Baranchikov, Alexander E., Sozarukova, Madina M., Ivanov, Vladimir K., Popov, Anton L. |
| Source: | Polymers (20734360); Sep2023, Vol. 15 Issue 18, p3840, 13p |
| Subject Terms: | Cerium oxides, Contrast media, Magnetic resonance imaging, Colloidal stability, Nanoparticles, Diagnostic imaging |
| Abstract: | Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their unique advantages and capability in drug delivery applications. These ordered micro/nanostructures are also promising candidates as imaging contrast agents for diagnostic and theranostic applications. Magnetic resonance imaging (MRI), one of the most powerful clinical imaging modalities, is moving forward to the molecular imaging field and requires advanced imaging probes. This paper reports on a new design of MRI-visible LbL capsules, loaded with redox-active gadolinium-doped cerium oxide nanoparticles (CeGdO |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:edb&genre=article&issn=20734360&ISBN=&volume=15&issue=18&date=20230915&spage=3840&pages=3840-3852&title=Polymers (20734360)&atitle=Hybrid%20Polyelectrolyte%20Capsules%20Loaded%20with%20Gadolinium-Doped%20Cerium%20Oxide%20Nanoparticles%20as%20a%20Biocompatible%20MRI%20Agent%20for%20Theranostic%20Applications.&aulast=Kolmanovich%2C%20Danil%20D.&id=DOI:10.3390/polym15183840 Name: Full Text Finder (for New FTF UI) (ns324271) Category: fullText Text: Full Text Finder MouseOverText: Full Text Finder |
|---|---|
| Header | DbId: edb DbLabel: Complementary Index An: 172420656 RelevancyScore: 944 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 943.778137207031 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kolmanovich%2C+Danil+D%2E%22">Kolmanovich, Danil D.</searchLink><br /><searchLink fieldCode="AR" term="%22Chukavin%2C+Nikita+N%2E%22">Chukavin, Nikita N.</searchLink><br /><searchLink fieldCode="AR" term="%22Savintseva%2C+Irina+V%2E%22">Savintseva, Irina V.</searchLink><br /><searchLink fieldCode="AR" term="%22Mysina%2C+Elena+A%2E%22">Mysina, Elena A.</searchLink><br /><searchLink fieldCode="AR" term="%22Popova%2C+Nelli+R%2E%22">Popova, Nelli R.</searchLink><br /><searchLink fieldCode="AR" term="%22Baranchikov%2C+Alexander+E%2E%22">Baranchikov, Alexander E.</searchLink><br /><searchLink fieldCode="AR" term="%22Sozarukova%2C+Madina+M%2E%22">Sozarukova, Madina M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ivanov%2C+Vladimir+K%2E%22">Ivanov, Vladimir K.</searchLink><br /><searchLink fieldCode="AR" term="%22Popov%2C+Anton+L%2E%22">Popov, Anton L.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Polymers (20734360); Sep2023, Vol. 15 Issue 18, p3840, 13p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Cerium+oxides%22">Cerium oxides</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Colloidal+stability%22">Colloidal stability</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their unique advantages and capability in drug delivery applications. These ordered micro/nanostructures are also promising candidates as imaging contrast agents for diagnostic and theranostic applications. Magnetic resonance imaging (MRI), one of the most powerful clinical imaging modalities, is moving forward to the molecular imaging field and requires advanced imaging probes. This paper reports on a new design of MRI-visible LbL capsules, loaded with redox-active gadolinium-doped cerium oxide nanoparticles (CeGdO<subscript>2−x</subscript> NPs). CeGdO<subscript>2−x</subscript> NPs possess an ultrasmall size, high colloidal stability, and pronounced antioxidant properties. A comprehensive analysis of LbL capsules by TEM, SEM, LCSM, and EDX techniques was carried out. The research demonstrated a high level of biocompatibility and cellular uptake efficiency of CeGdO<subscript>2−x</subscript>-loaded capsules by cancer (human osteosarcoma and adenocarcinoma) cells and normal (human mesenchymal stem) cells. The LbL-based delivery platform can also be used for other imaging modalities and theranostic applications. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=172420656 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym15183840 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 3840 Subjects: – SubjectFull: Cerium oxides Type: general – SubjectFull: Contrast media Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Colloidal stability Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Diagnostic imaging Type: general Titles: – TitleFull: Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kolmanovich, Danil D. – PersonEntity: Name: NameFull: Chukavin, Nikita N. – PersonEntity: Name: NameFull: Savintseva, Irina V. – PersonEntity: Name: NameFull: Mysina, Elena A. – PersonEntity: Name: NameFull: Popova, Nelli R. – PersonEntity: Name: NameFull: Baranchikov, Alexander E. – PersonEntity: Name: NameFull: Sozarukova, Madina M. – PersonEntity: Name: NameFull: Ivanov, Vladimir K. – PersonEntity: Name: NameFull: Popov, Anton L. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 09 Text: Sep2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 15 – Type: issue Value: 18 Titles: – TitleFull: Polymers (20734360) Type: main |
| ResultId | 1 |