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Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning.

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Title: Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning.
Authors: Geudens, Ilse, Coxam, Baptiste, Alt, Silvanus, Gebala, Véronique, Vion, Anne-Clémence, Meier, Katja, Rosa, Andre, Gerhardt, Holger
Source: Development (0950-1991); Aug2019, Vol. 146 Issue 15, p1-55, 55p
Subject Terms: Zebra danio embryos, Veins, Blood vessels, Endothelial cells, Arteries, Technical specifications, Endothelium, Brachial artery
Abstract: How developing vascular networks acquire the right balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood. In zebrafish embryos, the robust and regular 50:50 global balance of intersegmental veins and arteries that form along the trunk, prompts the intriguing question how the organism keeps “count”. Previous studies suggest that the ultimate fate of an intersegmental vessel (ISV) is determined by the identity of the approaching secondary sprout emerging from the posterior cardinal vein (PCV). Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell (EC) behavior and Notch signaling activity in the seemingly identical primary ISVs that is independent of secondary sprouting and flow. We show that Notch signaling mediates the local patterning of ISVs, and an adaptive flow-mediated mechanism subsequently fine-tunes the global balance of arteries and veins along the trunk. We propose that this dual mechanism provides the adaptability required to establish a balanced network of arteries, veins and lymphatic vessels. [ABSTRACT FROM AUTHOR]
Copyright of Development (0950-1991) is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubTypeId: academicJournal
PreciseRelevancyScore: 873.738098144531
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Geudens%2C+Ilse%22">Geudens, Ilse</searchLink><br /><searchLink fieldCode="AR" term="%22Coxam%2C+Baptiste%22">Coxam, Baptiste</searchLink><br /><searchLink fieldCode="AR" term="%22Alt%2C+Silvanus%22">Alt, Silvanus</searchLink><br /><searchLink fieldCode="AR" term="%22Gebala%2C+Véronique%22">Gebala, Véronique</searchLink><br /><searchLink fieldCode="AR" term="%22Vion%2C+Anne-Clémence%22">Vion, Anne-Clémence</searchLink><br /><searchLink fieldCode="AR" term="%22Meier%2C+Katja%22">Meier, Katja</searchLink><br /><searchLink fieldCode="AR" term="%22Rosa%2C+Andre%22">Rosa, Andre</searchLink><br /><searchLink fieldCode="AR" term="%22Gerhardt%2C+Holger%22">Gerhardt, Holger</searchLink>
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  Label: Source
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  Data: Development (0950-1991); Aug2019, Vol. 146 Issue 15, p1-55, 55p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Zebra+danio+embryos%22">Zebra danio embryos</searchLink><br /><searchLink fieldCode="DE" term="%22Veins%22">Veins</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+vessels%22">Blood vessels</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelial+cells%22">Endothelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Arteries%22">Arteries</searchLink><br /><searchLink fieldCode="DE" term="%22Technical+specifications%22">Technical specifications</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelium%22">Endothelium</searchLink><br /><searchLink fieldCode="DE" term="%22Brachial+artery%22">Brachial artery</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: How developing vascular networks acquire the right balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood. In zebrafish embryos, the robust and regular 50:50 global balance of intersegmental veins and arteries that form along the trunk, prompts the intriguing question how the organism keeps “count”. Previous studies suggest that the ultimate fate of an intersegmental vessel (ISV) is determined by the identity of the approaching secondary sprout emerging from the posterior cardinal vein (PCV). Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell (EC) behavior and Notch signaling activity in the seemingly identical primary ISVs that is independent of secondary sprouting and flow. We show that Notch signaling mediates the local patterning of ISVs, and an adaptive flow-mediated mechanism subsequently fine-tunes the global balance of arteries and veins along the trunk. We propose that this dual mechanism provides the adaptability required to establish a balanced network of arteries, veins and lymphatic vessels. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Development (0950-1991) is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1242/dev.181024
    Languages:
      – Code: eng
        Text: English
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        PageCount: 55
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    Subjects:
      – SubjectFull: Zebra danio embryos
        Type: general
      – SubjectFull: Veins
        Type: general
      – SubjectFull: Blood vessels
        Type: general
      – SubjectFull: Endothelial cells
        Type: general
      – SubjectFull: Arteries
        Type: general
      – SubjectFull: Technical specifications
        Type: general
      – SubjectFull: Endothelium
        Type: general
      – SubjectFull: Brachial artery
        Type: general
    Titles:
      – TitleFull: Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning.
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            NameFull: Geudens, Ilse
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            NameFull: Coxam, Baptiste
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            NameFull: Alt, Silvanus
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            NameFull: Vion, Anne-Clémence
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              M: 08
              Text: Aug2019
              Type: published
              Y: 2019
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              Value: 09501991
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              Value: 146
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              Value: 15
          Titles:
            – TitleFull: Development (0950-1991)
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