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The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications.

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Τίτλος: The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications.
Συγγραφείς: Hu, Zheng, Ma, Ding
Πηγή: Cancer Medicine; Oct2018, Vol. 7 Issue 10, p5217-5236, 20p
Θεματικοί όροι: Papillomavirus disease diagnosis, Cervical cancer treatment, Cancer invasiveness, Medical screening, Individualized medicine
Περίληψη: Cervical cancer is the third most common cancer in women worldwide, with concepts and knowledge about its prevention and treatment evolving rapidly. Human papillomavirus (HPV) has been identified as a major factor that leads to cervical cancer, although HPV infection alone cannot cause the disease. In fact, HPV‐driven cancer is a small probability event because most infections are transient and could be cleared spontaneously by host immune system. With persistent HPV infection, decades are required for progression to cervical cancer. Therefore, this long time window provides golden opportunity for clinical intervention, and the fundament here is to elucidate the carcinogenic pattern and applicable targets during HPV‐host interaction. In this review, we discuss the key factors that contribute to the persistence of HPV and cervical carcinogenesis, emerging new concepts and technologies for cancer interventions, and more urgently, how these concepts and technologies might lead to clinical precision medicine which could provide prediction, prevention, and early treatment for patients. We discussed the key factors that contribute to HPV persistency and cervical carcinogenesis, the perspective and novel potential technologies for early diagnose and effective prevention of the disease, and more importantly, how this knowledge of basic science may translate into clinic to provide better personalized health care for patients with cervical cancer. This review contributed to the deeper understanding of effective prevention, screening, and treatment of HPV‐related cervical cancer. [ABSTRACT FROM AUTHOR]
Copyright of Cancer Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Βάση Δεδομένων: Complementary Index
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PubType: Academic Journal
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  Data: Cancer Medicine; Oct2018, Vol. 7 Issue 10, p5217-5236, 20p
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  Data: <searchLink fieldCode="DE" term="%22Papillomavirus+disease+diagnosis%22">Papillomavirus disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cervical+cancer+treatment%22">Cervical cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+screening%22">Medical screening</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+medicine%22">Individualized medicine</searchLink>
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  Data: Cervical cancer is the third most common cancer in women worldwide, with concepts and knowledge about its prevention and treatment evolving rapidly. Human papillomavirus (HPV) has been identified as a major factor that leads to cervical cancer, although HPV infection alone cannot cause the disease. In fact, HPV‐driven cancer is a small probability event because most infections are transient and could be cleared spontaneously by host immune system. With persistent HPV infection, decades are required for progression to cervical cancer. Therefore, this long time window provides golden opportunity for clinical intervention, and the fundament here is to elucidate the carcinogenic pattern and applicable targets during HPV‐host interaction. In this review, we discuss the key factors that contribute to the persistence of HPV and cervical carcinogenesis, emerging new concepts and technologies for cancer interventions, and more urgently, how these concepts and technologies might lead to clinical precision medicine which could provide prediction, prevention, and early treatment for patients. We discussed the key factors that contribute to HPV persistency and cervical carcinogenesis, the perspective and novel potential technologies for early diagnose and effective prevention of the disease, and more importantly, how this knowledge of basic science may translate into clinic to provide better personalized health care for patients with cervical cancer. This review contributed to the deeper understanding of effective prevention, screening, and treatment of HPV‐related cervical cancer. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Cancer Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Oct2018
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