Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications. |
| Συγγραφείς: |
Hu, Zheng, Ma, Ding |
| Πηγή: |
Cancer Medicine; Oct2018, Vol. 7 Issue 10, p5217-5236, 20p |
| Θεματικοί όροι: |
Papillomavirus disease diagnosis, Cervical cancer treatment, Cancer invasiveness, Medical screening, Individualized medicine |
| Περίληψη: |
Cervical cancer is the third most common cancer in women worldwide, with concepts and knowledge about its prevention and treatment evolving rapidly. Human papillomavirus (HPV) has been identified as a major factor that leads to cervical cancer, although HPV infection alone cannot cause the disease. In fact, HPV‐driven cancer is a small probability event because most infections are transient and could be cleared spontaneously by host immune system. With persistent HPV infection, decades are required for progression to cervical cancer. Therefore, this long time window provides golden opportunity for clinical intervention, and the fundament here is to elucidate the carcinogenic pattern and applicable targets during HPV‐host interaction. In this review, we discuss the key factors that contribute to the persistence of HPV and cervical carcinogenesis, emerging new concepts and technologies for cancer interventions, and more urgently, how these concepts and technologies might lead to clinical precision medicine which could provide prediction, prevention, and early treatment for patients. We discussed the key factors that contribute to HPV persistency and cervical carcinogenesis, the perspective and novel potential technologies for early diagnose and effective prevention of the disease, and more importantly, how this knowledge of basic science may translate into clinic to provide better personalized health care for patients with cervical cancer. This review contributed to the deeper understanding of effective prevention, screening, and treatment of HPV‐related cervical cancer. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: |
Complementary Index |