Academic Journal
Προβολή σε EDS

RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis.
Συγγραφείς: Dai, Qingyun, Xu, Lei, Xiao, Lu, Zhu, Kaixiang, Song, Yunhong, Li, Changfu, Zhu, Lingfang, Shen, Xihui, Wang, Yao
Πηγή: Frontiers in Microbiology; 2/27/2018, p1-N.PAG, 12p
Θεματικοί όροι: Yersinia pseudotuberculosis, Urease genetics, Messenger RNA, Genetics
Περίληψη: Urease acts as an important acid resistance system and virulence factor that is widespread among microorganisms. RovM is a global regulator that regulates a series of genes and pathways including acid survival systems in the enteric bacterium Yersinia pseudotuberculosis (Yptb). However, whether RovM regulates the urease activity in Yptb was still unknown. In this study, by using qualitative and quantitative urease assays, we show that the urease expression responds to nutrient conditions and the RovM protein represses urease expression by binding to its promoter. A previously reported positive regulator OmpR activates urease activity but RovM plays a dominant role in different nutrient conditions. In addition, carbon storage regulator system A (CsrA), the upstream regulator of RovM, dramatically down-regulates urease activity possibly by its binding to the Shine-Dalgarno (SD) sequence of the mRNA encoding the urease. In conclusion, this study demonstrates that urease activity is strictly controlled by nutrient conditions and is down-regulated by the CsrA-RovM pathway. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Microbiology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Βάση Δεδομένων: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:edb&genre=article&issn=1664302X&ISBN=&volume=&issue=&date=20180227&spage=1&pages=1-12&title=Frontiers in Microbiology&atitle=RovM%20and%20CsrA%20Negatively%20Regulate%20Urease%20Expression%20in%20Yersinia%20pseudotuberculosis.&aulast=Dai%2C%20Qingyun&id=DOI:10.3389/fmicb.2018.00348
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: edb
DbLabel: Complementary Index
An: 128224521
RelevancyScore: 862
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 861.6259765625
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dai%2C+Qingyun%22">Dai, Qingyun</searchLink><br /><searchLink fieldCode="AR" term="%22Xu%2C+Lei%22">Xu, Lei</searchLink><br /><searchLink fieldCode="AR" term="%22Xiao%2C+Lu%22">Xiao, Lu</searchLink><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Kaixiang%22">Zhu, Kaixiang</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+Yunhong%22">Song, Yunhong</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Changfu%22">Li, Changfu</searchLink><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Lingfang%22">Zhu, Lingfang</searchLink><br /><searchLink fieldCode="AR" term="%22Shen%2C+Xihui%22">Shen, Xihui</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yao%22">Wang, Yao</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Frontiers in Microbiology; 2/27/2018, p1-N.PAG, 12p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Yersinia+pseudotuberculosis%22">Yersinia pseudotuberculosis</searchLink><br /><searchLink fieldCode="DE" term="%22Urease+genetics%22">Urease genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Urease acts as an important acid resistance system and virulence factor that is widespread among microorganisms. RovM is a global regulator that regulates a series of genes and pathways including acid survival systems in the enteric bacterium Yersinia pseudotuberculosis (Yptb). However, whether RovM regulates the urease activity in Yptb was still unknown. In this study, by using qualitative and quantitative urease assays, we show that the urease expression responds to nutrient conditions and the RovM protein represses urease expression by binding to its promoter. A previously reported positive regulator OmpR activates urease activity but RovM plays a dominant role in different nutrient conditions. In addition, carbon storage regulator system A (CsrA), the upstream regulator of RovM, dramatically down-regulates urease activity possibly by its binding to the Shine-Dalgarno (SD) sequence of the mRNA encoding the urease. In conclusion, this study demonstrates that urease activity is strictly controlled by nutrient conditions and is down-regulated by the CsrA-RovM pathway. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Microbiology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=128224521
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fmicb.2018.00348
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1
    Subjects:
      – SubjectFull: Yersinia pseudotuberculosis
        Type: general
      – SubjectFull: Urease genetics
        Type: general
      – SubjectFull: Messenger RNA
        Type: general
      – SubjectFull: Genetics
        Type: general
    Titles:
      – TitleFull: RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dai, Qingyun
      – PersonEntity:
          Name:
            NameFull: Xu, Lei
      – PersonEntity:
          Name:
            NameFull: Xiao, Lu
      – PersonEntity:
          Name:
            NameFull: Zhu, Kaixiang
      – PersonEntity:
          Name:
            NameFull: Song, Yunhong
      – PersonEntity:
          Name:
            NameFull: Li, Changfu
      – PersonEntity:
          Name:
            NameFull: Zhu, Lingfang
      – PersonEntity:
          Name:
            NameFull: Shen, Xihui
      – PersonEntity:
          Name:
            NameFull: Wang, Yao
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 27
              M: 02
              Text: 2/27/2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 1664302X
          Titles:
            – TitleFull: Frontiers in Microbiology
              Type: main
ResultId 1