Academic Journal
Comparison of two rapid urease tests for detection of Helicobacter pylori infection.
| Title: | Comparison of two rapid urease tests for detection of Helicobacter pylori infection. |
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| Authors: | Chen YK; Department of Medicine, Loma Linda University School of Medicine, California 92354, USA., Godil A, Wat PJ |
| Source: | Digestive diseases and sciences [Dig Dis Sci] 1998 Aug; Vol. 43 (8), pp. 1636-40. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print Cited Medium: Print ISSN: 0163-2116 (Print) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005- : New York, NY : Springer Science + Business Media Original Publication: New York, Plenum Pub. Corp. |
| MeSH Terms: | Helicobacter pylori*/enzymology, Helicobacter Infections/*diagnosis , Stomach Diseases/*diagnosis , Urease/*analysis, Gastric Mucosa/enzymology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Endoscopy, Digestive System ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Reagent Strips ; Sensitivity and Specificity |
| Abstract: | Rapid urease tests are widely used at endoscopy to determine the presence of Helicobacter pylori infection. In this prospective study, we compared the accuracy of two rapid urease tests, CLOtest and PyloriTek, using histology as the gold standard. Histologic staining was performed using both H&E and Giemsa, and all slides were reviewed by a single pathologist who was blinded to the results of the rapid urease tests and endoscopic findings. One hundred two patients were enrolled; their mean age was 59 years (range 16 to 95 years), and there were 45 males and 57 females. Histology confirmed the presence of H. pylori infection in 39% of patients. The proportions of false positives for CLOtest (8.0%) and PyloriTek measured at 1 hr (29.0%) were significantly different (Z = 2.90, P = 0.0038). No significant difference was seen between the proportions of false negatives. We conclude that the clinical usefulness of PyloriTek urease test is limited by its lack of specificity. |
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| Substance Nomenclature: | 0 (Reagent Strips) EC 3.5.1.5 (Urease) |
| Entry Date(s): | Date Created: 19980902 Date Completed: 19980916 Latest Revision: 20190721 |
| Update Code: | 20260130 |
| DOI: | 10.1023/a:1018838410272 |
| PMID: | 9724143 |
| Database: | MEDLINE |
| ISSN: | 0163-2116 |
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| DOI: | 10.1023/a:1018838410272 |