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The role of different histocompatibility testing methods for selection of related and unrelated bone marrow donors.

Bibliographic Details
Title: The role of different histocompatibility testing methods for selection of related and unrelated bone marrow donors.
Authors: Oudshoorn M; Europdonor Foundation, University Hospital Leiden, The Netherlands., van Leeuwen A, van Rood JJ
Source: Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine [Beitr Infusionsther Transfusionsmed] 1994; Vol. 32, pp. 250-5.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Language: English
Journal Info: Publisher: Karger Country of Publication: Switzerland NLM ID: 9442459 Publication Model: Print Cited Medium: Print ISSN: 1023-2028 (Print) Linking ISSN: 10232028 NLM ISO Abbreviation: Beitr Infusionsther Transfusionsmed Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel ; New York : Karger, c1994-
MeSH Terms: Histocompatibility Testing* , Living Donors*, Bone Marrow Transplantation/*immunology, Graft vs Host Disease/prevention & control ; Family ; Female ; Haplotypes ; Humans ; Male ; Patient Selection ; Pedigree ; Registries ; Sensitivity and Specificity
Abstract: Bone marrow transplantation has become the treatment of choice for many hematological malignancies. Approximately 30% of the patients lack an HLA-identical sibling donor, for them alternative donors have to be found. The chances of finding an unrelated donor can be estimated by consulting the Bone Marrow Donors Worldwide file and grouping the patients according to whether they have frequent or rare haplotypes. If the HLA-ABDR split antigens are taken into account, for less than 25% of the patients identical donors can be identified. In order to select the best matched donor for a patient, sensitive HLA typing techniques should be employed including DNA typing techniques, but for optimal selection of a suitable donor one should not only study genetics but also determine the immunological repertoire recognizing the histocompatibility differences between donor and recipient. Several promising cellular techniques such as the HTLp and CTLp test have recently become available and should also be used to select the best donor.
Entry Date(s): Date Created: 19940101 Date Completed: 19980225 Latest Revision: 20061115
Update Code: 20260130
PMID: 9422112
Database: MEDLINE
FullText Text:
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DbLabel: MEDLINE
An: 9422112
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The role of different histocompatibility testing methods for selection of related and unrelated bone marrow donors.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Oudshoorn+M%22">Oudshoorn M</searchLink>; Europdonor Foundation, University Hospital Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Leeuwen+A%22">van Leeuwen A</searchLink><br /><searchLink fieldCode="AU" term="%22van+Rood+JJ%22">van Rood JJ</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229442459%22">Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine</searchLink> [Beitr Infusionsther Transfusionsmed] 1994; Vol. 32, pp. 250-5.
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  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Karger%22">Karger </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9442459 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>1023-2028 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210232028%22">10232028 </searchLink><i>NLM ISO Abbreviation: </i>Beitr Infusionsther Transfusionsmed <i>Subsets: </i>MEDLINE
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  Label: Imprint Name(s)
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  Data: <i>Original Publication</i>: Basel ; New York : Karger, c1994-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Histocompatibility+Testing%22">Histocompatibility Testing*</searchLink> <br /><searchLink fieldCode="MM" term="%22Living+Donors%22">Living Donors*</searchLink><br /><searchLink fieldCode="MM" term="%22Bone+Marrow+Transplantation%22">Bone Marrow Transplantation</searchLink>/<searchLink fieldCode="MM" term="%22Bone+Marrow+Transplantation+immunology%22">*immunology</searchLink><br /><searchLink fieldCode="MH" term="%22Graft+vs+Host+Disease%22">Graft vs Host Disease</searchLink>/<searchLink fieldCode="MH" term="%22Graft+vs+Host+Disease+prevention+%26+control%22">prevention & control</searchLink> ; <searchLink fieldCode="MH" term="%22Family%22">Family</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Haplotypes%22">Haplotypes</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Patient+Selection%22">Patient Selection</searchLink> ; <searchLink fieldCode="MH" term="%22Pedigree%22">Pedigree</searchLink> ; <searchLink fieldCode="MH" term="%22Registries%22">Registries</searchLink> ; <searchLink fieldCode="MH" term="%22Sensitivity+and+Specificity%22">Sensitivity and Specificity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Bone marrow transplantation has become the treatment of choice for many hematological malignancies. Approximately 30% of the patients lack an HLA-identical sibling donor, for them alternative donors have to be found. The chances of finding an unrelated donor can be estimated by consulting the Bone Marrow Donors Worldwide file and grouping the patients according to whether they have frequent or rare haplotypes. If the HLA-ABDR split antigens are taken into account, for less than 25% of the patients identical donors can be identified. In order to select the best matched donor for a patient, sensitive HLA typing techniques should be employed including DNA typing techniques, but for optimal selection of a suitable donor one should not only study genetics but also determine the immunological repertoire recognizing the histocompatibility differences between donor and recipient. Several promising cellular techniques such as the HTLp and CTLp test have recently become available and should also be used to select the best donor.
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>19940101 <i>Date Completed: </i>19980225 <i>Latest Revision: </i>20061115
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260130
– Name: AN
  Label: PMID
  Group: ID
  Data: 9422112
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=9422112
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 250
    Subjects:
      – SubjectFull: Graft vs Host Disease prevention & control
        Type: general
      – SubjectFull: Family
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Haplotypes
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Patient Selection
        Type: general
      – SubjectFull: Pedigree
        Type: general
      – SubjectFull: Registries
        Type: general
      – SubjectFull: Sensitivity and Specificity
        Type: general
      – SubjectFull: Histocompatibility Testing
        Type: general
      – SubjectFull: Living Donors
        Type: general
      – SubjectFull: Bone Marrow Transplantation immunology
        Type: general
    Titles:
      – TitleFull: The role of different histocompatibility testing methods for selection of related and unrelated bone marrow donors.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Oudshoorn M
      – PersonEntity:
          Name:
            NameFull: van Leeuwen A
      – PersonEntity:
          Name:
            NameFull: van Rood JJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: 1994
              Type: published
              Y: 1994
          Identifiers:
            – Type: issn-print
              Value: 1023-2028
          Numbering:
            – Type: volume
              Value: 32
          Titles:
            – TitleFull: Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine
              Type: main
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