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[Quantitative processing of results of uniparametric fluorescent flow analysis of human chromosomes].

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Τίτλος: [Quantitative processing of results of uniparametric fluorescent flow analysis of human chromosomes].
Μεταγλωττισμένος Τίτλος: Kolichestvennaia obrabotka rezul'tatov odnoparametricheskogo fluorestsentnogo analiza khromosom cheloveka v potoke.
Συγγραφείς: Kravatskiĭ IuV, Poletaev AI
Πηγή: Molekuliarnaia biologiia [Mol Biol (Mosk)] 1994 Jul-Aug; Vol. 28 (4), pp. 887-99.
Τύπος έκδοσης: English Abstract; Journal Article
Γλώσσα: Russian
Στοιχεία περιοδικού: Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE
Imprint Name(s): Original Publication: Moskva : Izdatelstvo Nauka
Ιατρικοί όροι (MeSH): Chromosomes, Human*, Flow Cytometry/*methods, Algorithms ; Chromosome Aberrations ; Fourier Analysis ; Humans ; Karyotyping ; Microcomputers
Περίληψη: The proposed procedure of computer analysis of the flow karyotype data, obtained in human chromosomes studies, is able to provide information about the basic parameters of the karyotypes: the positions of the peaks (corresponding to the relative size of chromosomes), peaks areas (relative number of chromosomes in the sample), coefficients of variation (CV) of the peaks--possible differences between homologous chromosomes. The analysis is based on the assumption that all chromosomal components of the experimental distributions are normal (Gaussians). The algorithm of the analysis uses a combination of two approaches: truncation method and least squares method. As the flow data are "contaminated" by background components, special tools for filtering off the contaminating signals were designed including the original integral Fourier filtering procedure. This analysis is realized in a program package utilizing IBM-compatible PCs. The user is able to get the desired parameters for most chromosomes of the karyotype under study from univariate flow data: differences between particular homologous chromosomes, presence of chromosome aberrations, extra chromosomes, etc., since structural aberrations and chromosome number variation lead to specific changes of the parameters of chromosome-related components.
Entry Date(s): Date Created: 19940701 Date Completed: 19950112 Latest Revision: 20061115
Update Code: 20260130
PMID: 7990817
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
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DbLabel: MEDLINE
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AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: [Quantitative processing of results of uniparametric fluorescent flow analysis of human chromosomes].
– Name: TitleTranslated
  Label: Transliterated Title
  Group: TiAlt
  Data: Kolichestvennaia obrabotka rezul'tatov odnoparametricheskogo fluorestsentnogo analiza khromosom cheloveka v potoke.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Kravatskiĭ+IuV%22">Kravatskiĭ IuV</searchLink><br /><searchLink fieldCode="AU" term="%22Poletaev+AI%22">Poletaev AI</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220105454%22">Molekuliarnaia biologiia</searchLink> [Mol Biol (Mosk)] 1994 Jul-Aug; Vol. 28 (4), pp. 887-99.
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  Data: English Abstract; Journal Article
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  Data: Russian
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Izdatelstvo+Nauka%22">Izdatelstvo Nauka </searchLink><i>Country of Publication: </i>Russia (Federation) <i>NLM ID: </i>0105454 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>0026-8984 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200268984%22">00268984 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biol (Mosk) <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Moskva : Izdatelstvo Nauka
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Chromosomes%2C+Human%22">Chromosomes, Human*</searchLink><br /><searchLink fieldCode="MM" term="%22Flow+Cytometry%22">Flow Cytometry</searchLink>/<searchLink fieldCode="MM" term="%22Flow+Cytometry+methods%22">*methods</searchLink><br /><searchLink fieldCode="MH" term="%22Algorithms%22">Algorithms</searchLink> ; <searchLink fieldCode="MH" term="%22Chromosome+Aberrations%22">Chromosome Aberrations</searchLink> ; <searchLink fieldCode="MH" term="%22Fourier+Analysis%22">Fourier Analysis</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Karyotyping%22">Karyotyping</searchLink> ; <searchLink fieldCode="MH" term="%22Microcomputers%22">Microcomputers</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The proposed procedure of computer analysis of the flow karyotype data, obtained in human chromosomes studies, is able to provide information about the basic parameters of the karyotypes: the positions of the peaks (corresponding to the relative size of chromosomes), peaks areas (relative number of chromosomes in the sample), coefficients of variation (CV) of the peaks--possible differences between homologous chromosomes. The analysis is based on the assumption that all chromosomal components of the experimental distributions are normal (Gaussians). The algorithm of the analysis uses a combination of two approaches: truncation method and least squares method. As the flow data are "contaminated" by background components, special tools for filtering off the contaminating signals were designed including the original integral Fourier filtering procedure. This analysis is realized in a program package utilizing IBM-compatible PCs. The user is able to get the desired parameters for most chromosomes of the karyotype under study from univariate flow data: differences between particular homologous chromosomes, presence of chromosome aberrations, extra chromosomes, etc., since structural aberrations and chromosome number variation lead to specific changes of the parameters of chromosome-related components.
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  Label: Entry Date(s)
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  Data: <i>Date Created: </i>19940701 <i>Date Completed: </i>19950112 <i>Latest Revision: </i>20061115
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  Data: 7990817
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=7990817
RecordInfo BibRecord:
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    Languages:
      – Code: rus
        Text: Russian
    PhysicalDescription:
      Pagination:
        StartPage: 887
    Subjects:
      – SubjectFull: Algorithms
        Type: general
      – SubjectFull: Chromosome Aberrations
        Type: general
      – SubjectFull: Fourier Analysis
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Karyotyping
        Type: general
      – SubjectFull: Microcomputers
        Type: general
      – SubjectFull: Chromosomes, Human
        Type: general
      – SubjectFull: Flow Cytometry methods
        Type: general
    Titles:
      – TitleFull: [Quantitative processing of results of uniparametric fluorescent flow analysis of human chromosomes].
        Type: main
  BibRelationships:
    HasContributorRelationships:
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          Name:
            NameFull: Kravatskiĭ IuV
      – PersonEntity:
          Name:
            NameFull: Poletaev AI
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          Dates:
            – D: 01
              M: 07
              Text: 1994 Jul-Aug
              Type: published
              Y: 1994
          Identifiers:
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              Value: 0026-8984
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            – Type: volume
              Value: 28
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Molekuliarnaia biologiia
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