Academic Journal
Efficient Propranolol Delivery Enabled by Manganese-Based Bioactive Metal-Organic Frameworks With High Loading Capacity.
| Τίτλος: | Efficient Propranolol Delivery Enabled by Manganese-Based Bioactive Metal-Organic Frameworks With High Loading Capacity. |
|---|---|
| Συγγραφείς: | Borhanipasvisheh H; Department of Inorganic Chemistry, Faculty of Chemistry, University of Guilan, Rasht, Iran., Dehghani Siyahaki S; Chemical Engineering Department, University of Kashan, Kashan, Iran., Gholamhosseinzadeh E; Department of Chemistry, University of Turin, Turin, Italy. |
| Πηγή: | ChemistryOpen [ChemistryOpen] 2026 Nov; Vol. 15 (11), pp. e70319. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101594811 Publication Model: Print Cited Medium: Internet ISSN: 2191-1363 (Electronic) Linking ISSN: 21911363 NLM ISO Abbreviation: ChemistryOpen Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Weinheim : Wiley-VCH Verlag |
| Ιατρικοί όροι (MeSH): | Propranolol*/chemistry , Propranolol*/administration & dosage , Manganese*/chemistry , Drug Carriers*/chemistry, Hemolysis/drug effects ; Drug Liberation ; Humans |
| Περίληψη: | A green and efficient method was developed for propranolol delivery utilizing manganese-based bioactive metal-organic frameworks (MOFs) as biocompatible drug carriers. Mn-based bioactive MOFs with a high aspect ratio were synthesized and characterized for size (average, 17 µm), morphology, stability, elemental composition, crystallinity, functionality, charge character, and biocompatibility (a protein adsorption capacity of 0.03 µg µg-1 (5 h) and a hemolysis ratio of < 0.5%). Afterward, the MOFs were utilized for drug loading via an encapsulation method, and the drug release studies were also performed. The drug loading was confirmed using the zeta potential, CHN analysis, and thermogravimetric analysis (TGA) measurements. An encapsulation efficiency of 96% (0.5 W/W (drug/MOFs)) and a maximal capacity (Q (© 2026 The Authors. ChemistryOpen published by Wiley‐VCH GmbH.) |
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| Contributed Indexing: | Keywords: bio‐active MOFs; drug delivery; drug release kinetics; encapsulation; propranolol delivery |
| Substance Nomenclature: | 9Y8NXQ24VQ (Propranolol) 42Z2K6ZL8P (Manganese) 0 (Drug Carriers) |
| Entry Date(s): | Date Created: 20261019 Date Completed: 20261019 Latest Revision: 20261024 |
| Update Code: | 20261024 |
| PubMed Central ID: | PMC13677820 |
| DOI: | 10.1002/open.70319 |
| PMID: | 42894273 |
| Βάση Δεδομένων: | MEDLINE |
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