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Disrupted Sensory-Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping.

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Title: Disrupted Sensory-Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping.
Authors: Abudouxukuer Z; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China., Afiadenyo M; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China., Yang Z; School of Psychological Sciences, Monash University, Clayton, Victoria, Australia., Becker B; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.; Department of Psychology, The University of Hong Kong, Hong Kong, China., Ferraro S; China-Cuba Belt and Road Joint Laboratory on Neurotechnology and Brain-Apparatus Communication, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China., Agoalikum E; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China.; Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Angmorterh SK; Department of Medical Imaging School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana., Djankpa FT; Department of Physiology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana., Adams L; Department of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana., Biswal BB; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA., Klugah-Brown B; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.; China-Cuba Belt and Road Joint Laboratory on Neurotechnology and Brain-Apparatus Communication, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Source: Brain and behavior [Brain Behav] 2026 Oct; Vol. 16 (10), pp. e71823.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE
Imprint Name(s): Original Publication: Hoboken, NJ : John Wiley & Sons
MeSH Terms: Internet Addiction Disorder*/physiopathology , Internet Addiction Disorder*/diagnostic imaging , Gray Matter*/diagnostic imaging , Gray Matter*/physiopathology , Brain*/physiopathology , Brain*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging , Video Games*, Brain Mapping/methods ; Neural Pathways/physiopathology ; Thalamus/diagnostic imaging ; Thalamus/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Female ; Young Adult ; Adult ; Digital Media
Abstract: Introduction: Excessive online gaming (EOG) is a transitional stage between recreational gaming and internet gaming disorder (IGD), characterized by impaired self-control and escalating engagement. Early identification of neural and behavioral vulnerabilities is crucial for understanding IGD development.
Methods: Fifty-nine young adults (30 EOG, 29 controls) completed structural MRI and behavioral assessments, including the IGD Scale-Short Form (IGDS9-SF) and the Liebowitz Social Anxiety Scale (LSAS). Source-based morphometry (SBM) identified independent gray matter networks, while behavioral profiling and receptor-level mapping examined functional and neurochemical associations.
Results: SBM revealed six gray matter components, with one network encompassing the right thalamus and precentral gyrus showing reduced loading in EOG, which negatively correlated with IGDS9-SF scores. Behavioral annotation linked this network to sensory integration, attention, and motor-executive control. Spatial overlap with serotonergic and dopaminergic receptor distributions indicated potential neurotransmitter involvement.
Conclusion: Early alterations in sensory-motor networks and associated neurotransmitter systems may contribute to impaired self-regulation and heightened reward sensitivity, providing a multimodal framework for understanding the progression from excessive gaming to IGD.
(© 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
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Grant Information: 2022ZD0208500 China MOST2030 Brain Project; The China MOST2030 Brain Project
Contributed Indexing: Keywords: gray matter networks; internet gaming disorder; serotonin–dopamine coupling; source‐based morphometry
Entry Date(s): Date Created: 20261009 Date Completed: 20261009 Latest Revision: 20261011
Update Code: 20261011
PubMed Central ID: PMC13650394
DOI: 10.1002/brb3.71823
PMID: 42851004
Database: MEDLINE
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  Data: Disrupted Sensory-Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping.
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  Data: <searchLink fieldCode="AU" term="%22Abudouxukuer+Z%22">Abudouxukuer Z</searchLink>; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Afiadenyo+M%22">Afiadenyo M</searchLink>; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Becker+B%22">Becker B</searchLink>; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.; Department of Psychology, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ferraro+S%22">Ferraro S</searchLink>; China-Cuba Belt and Road Joint Laboratory on Neurotechnology and Brain-Apparatus Communication, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Agoalikum+E%22">Agoalikum E</searchLink>; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China.; Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Angmorterh+SK%22">Angmorterh SK</searchLink>; Department of Medical Imaging School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.<br /><searchLink fieldCode="AU" term="%22Djankpa+FT%22">Djankpa FT</searchLink>; Department of Physiology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.<br /><searchLink fieldCode="AU" term="%22Adams+L%22">Adams L</searchLink>; Department of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.<br /><searchLink fieldCode="AU" term="%22Biswal+BB%22">Biswal BB</searchLink>; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Klugah-Brown+B%22">Klugah-Brown B</searchLink>; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.; China-Cuba Belt and Road Joint Laboratory on Neurotechnology and Brain-Apparatus Communication, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
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  Data: <i>Original Publication</i>: Hoboken, NJ : John Wiley & Sons
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  Data: <searchLink fieldCode="MM" term="%22Internet+Addiction+Disorder%22">Internet Addiction Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Internet+Addiction+Disorder+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Internet+Addiction+Disorder%22">Internet Addiction Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Internet+Addiction+Disorder+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Gray+Matter%22">Gray Matter*</searchLink>/<searchLink fieldCode="MM" term="%22Gray+Matter+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Gray+Matter%22">Gray Matter*</searchLink>/<searchLink fieldCode="MM" term="%22Gray+Matter+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Nerve+Net%22">Nerve Net*</searchLink>/<searchLink fieldCode="MM" term="%22Nerve+Net+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Nerve+Net%22">Nerve Net*</searchLink>/<searchLink fieldCode="MM" term="%22Nerve+Net+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Video+Games%22">Video Games*</searchLink><br /><searchLink fieldCode="MH" term="%22Brain+Mapping%22">Brain Mapping</searchLink>/<searchLink fieldCode="MH" term="%22Brain+Mapping+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Neural+Pathways%22">Neural Pathways</searchLink>/<searchLink fieldCode="MH" term="%22Neural+Pathways+physiopathology%22">physiopathology</searchLink> ; <searchLink fieldCode="MH" term="%22Thalamus%22">Thalamus</searchLink>/<searchLink fieldCode="MH" term="%22Thalamus+diagnostic+imaging%22">diagnostic imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Thalamus%22">Thalamus</searchLink>/<searchLink fieldCode="MH" term="%22Thalamus+physiopathology%22">physiopathology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Magnetic+Resonance+Imaging%22">Magnetic Resonance Imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Young+Adult%22">Young Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Digital+Media%22">Digital Media</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Excessive online gaming (EOG) is a transitional stage between recreational gaming and internet gaming disorder (IGD), characterized by impaired self-control and escalating engagement. Early identification of neural and behavioral vulnerabilities is crucial for understanding IGD development.<br />Methods: Fifty-nine young adults (30 EOG, 29 controls) completed structural MRI and behavioral assessments, including the IGD Scale-Short Form (IGDS9-SF) and the Liebowitz Social Anxiety Scale (LSAS). Source-based morphometry (SBM) identified independent gray matter networks, while behavioral profiling and receptor-level mapping examined functional and neurochemical associations.<br />Results: SBM revealed six gray matter components, with one network encompassing the right thalamus and precentral gyrus showing reduced loading in EOG, which negatively correlated with IGDS9-SF scores. Behavioral annotation linked this network to sensory integration, attention, and motor-executive control. Spatial overlap with serotonergic and dopaminergic receptor distributions indicated potential neurotransmitter involvement.<br />Conclusion: Early alterations in sensory-motor networks and associated neurotransmitter systems may contribute to impaired self-regulation and heightened reward sensitivity, providing a multimodal framework for understanding the progression from excessive gaming to IGD.<br /> (© 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
– Name: Ref
  Label: References
  Group: RefInfo
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  Group: Grant
  Data: 2022ZD0208500 China MOST2030 Brain Project; The China MOST2030 Brain Project
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  Label: Contributed Indexing
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  Data: <i>Keywords: </i>gray matter networks; internet gaming disorder; serotonin–dopamine coupling; source‐based morphometry
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  Data: <i>Date Created: </i>20261009 <i>Date Completed: </i>20261009 <i>Latest Revision: </i>20261011
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  Data: 10.1002/brb3.71823
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        Text: English
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        StartPage: e71823
    Subjects:
      – SubjectFull: Brain Mapping methods
        Type: general
      – SubjectFull: Neural Pathways physiopathology
        Type: general
      – SubjectFull: Thalamus diagnostic imaging
        Type: general
      – SubjectFull: Thalamus physiopathology
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      – SubjectFull: Humans
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      – SubjectFull: Magnetic Resonance Imaging
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      – SubjectFull: Adult
        Type: general
      – SubjectFull: Digital Media
        Type: general
      – SubjectFull: Internet Addiction Disorder physiopathology
        Type: general
      – SubjectFull: Internet Addiction Disorder diagnostic imaging
        Type: general
      – SubjectFull: Gray Matter diagnostic imaging
        Type: general
      – SubjectFull: Gray Matter physiopathology
        Type: general
      – SubjectFull: Brain physiopathology
        Type: general
      – SubjectFull: Brain diagnostic imaging
        Type: general
      – SubjectFull: Nerve Net physiopathology
        Type: general
      – SubjectFull: Nerve Net diagnostic imaging
        Type: general
      – SubjectFull: Video Games
        Type: general
    Titles:
      – TitleFull: Disrupted Sensory-Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping.
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            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
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            – TitleFull: Brain and behavior
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