Academic Journal
Impact of alcohol abstinence on hepatic enzymes: A clinical analysis at the rehabilitation center of Kathmandu.
| Τίτλος: | Impact of alcohol abstinence on hepatic enzymes: A clinical analysis at the rehabilitation center of Kathmandu. |
|---|---|
| Συγγραφείς: | Singh S; Department of Clinical Pharmacy, Central Institute of Science and Technology, Pokhara University, Nepal., Barma S; Department of Drug Administration, Ministry of Health and Food Safety, Government of Nepal, Nepal., Das MK; Valley College of Technical Sciences, Purbanchal University, Nepal., Bhuju GB; Department of Clinical Pharmacy, Central Institute of Science and Technology, Pokhara University, Nepal. |
| Πηγή: | The Journal of international medical research [J Int Med Res] 2026 Oct; Vol. 54 (10), pp. 3000605261490827. Date of Electronic Publication: 2026 Oct 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Nov. 2012- : London : Sage Publications Original Publication: Northampton, Eng., Cambridge Medical Publications ltd. |
| Ιατρικοί όροι (MeSH): | Liver*/enzymology , Liver Diseases, Alcoholic*/enzymology , Liver Diseases, Alcoholic*/rehabilitation , Liver Diseases, Alcoholic*/blood , Alcoholism*/rehabilitation , Alcoholism*/enzymology , Alcohol Abstinence*, Alkaline Phosphatase/blood ; Alkaline Phosphatase/metabolism ; Aspartate Aminotransferases/blood ; Aspartate Aminotransferases/metabolism ; Alanine Transaminase/blood ; Alanine Transaminase/metabolism ; Bilirubin/blood ; Humans ; Male ; Female ; Nepal ; Middle Aged ; Adult ; Prospective Studies ; Rehabilitation Centers ; Alcohol Drinking |
| Περίληψη: | ObjectiveAlcoholic liver disease is a major cause of liver-related mortality, accounting for approximately half of cirrhosis-related deaths. This study aimed to evaluate the impact of alcohol abstinence on liver enzyme alterations.MethodsThis prospective cohort study was conducted over 8 months at Amrita Foundation, Kathmandu, and involved patients with alcohol dependence syndrome who had confirmed alcoholic liver disease. A structured questionnaire was used for data collection. Descriptive and inferential statistics were performed.ResultThe study included 96 patients with alcohol dependence syndrome, of whom 72 were diagnosed with alcoholic liver disease. Age was positively correlated with alcohol consumption and duration of alcohol consumption. After 1 month of abstinence, elevated liver enzyme levels began to normalize, with alkaline phosphatase decreasing from 161.69 ± 79.084 to 89.90 ± 51.109, alanine aminotransferase from 156.60 ± 75.59 to 55.20 ± 25.944, and aspartate aminotransferase from 159.50 ± 72.959 to 62.20 ± 30.77. Bilirubin levels also decreased from 1.6940 ± 0.59 to 1.33 ± 0.445 compared with baseline values, indicating an improvement in liver function. The findings showed significant reductions in liver enzyme levels after abstinence (p < 0.001). Correlation analysis demonstrated strong positive relationships (p < 0.001) between pre- and post-abstinence levels of liver enzymes and bilirubin, with alkaline phosphatase showing the highest correlation (r = 0.94), followed by bilirubin (r = 0.87), aspartate aminotransferase (r = 0.84), and alanine aminotransferase (r = 0.78).ConclusionAlcohol abstinence resulted in significant biochemical remission in patients with alcoholic liver disease, as evidenced by marked reductions in liver enzyme and bilirubin levels within 1 month. These findings underscore sustained abstinence as a cornerstone of effective management of alcoholic liver disease. They also highlight the potential for liver recovery, the impact of chronic alcohol consumption, and the importance of rehabilitation support. |
| Contributed Indexing: | Keywords: Alcohol abstinence; alcoholic liver disease; hepatic enzyme; liver enzyme alteration; rehabilitation center |
| Substance Nomenclature: | EC 3.1.3.1 (Alkaline Phosphatase) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) RFM9X3LJ49 (Bilirubin) |
| Entry Date(s): | Date Created: 20261008 Date Completed: 20261008 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1177/03000605261490827 |
| PMID: | 42844782 |
| Βάση Δεδομένων: | MEDLINE |
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